(Q38406031)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28165467%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

title

APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury (English)

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1 April 2020

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10

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1 April 2020

author name string

Jin Joo Cha

1

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1 April 2020

Hye Sook Min

2

1 reference

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1 April 2020

Ki Tae Kim

3

1 reference

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1 April 2020

Jung Eun Kim

4

1 reference

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1 April 2020

Jung Yeon Ghee

5

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1 April 2020

Hyun Wook Kim

6

1 reference

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1 April 2020

Ji Eun Lee

7

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1 April 2020

Jee Young Han

8

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1 April 2020

Gayoung Lee

9

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1 April 2020

Yun Soo Bae

11

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1 April 2020

Sae Rom Lee

12

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1 April 2020

Sung Hwan Moon

13

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1 April 2020

Sung Chan Lee

14

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1 April 2020

Ganghyun Kim

15

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1 April 2020

Young Sun Kang

16

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1 April 2020

Dae Ryong Cha

17

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1 April 2020

publication date

6 February 2017

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1 April 2020

published in

Laboratory Investigation

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1 April 2020

volume

97

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1 April 2020

issue

4

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1 April 2020

page(s)

419-431

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https://scigraph.springernature.com/pub.10.1038/labinvest.2017.2

1 April 2020

exact match

0 references

cites work

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Oxidative stress as a major culprit in kidney disease in diabetes

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NADPH oxidases in the kidney

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Nox as a target for diabetic complications

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NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation

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NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.

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Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase

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Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy

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Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy

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Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells

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Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment

21 January 2018

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Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney

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Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice

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Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes

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Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

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Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice

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