(Q38409371)

2 September 2017

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title

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter (English)

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2 September 2017

John L Wallace

1

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PubMed ID

25849904

2 September 2017

Rui Wang

series ordinal

2

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2 September 2017

7 April 2015

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Nature Reviews Drug Discovery

2 September 2017

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2 September 2017

14

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2 September 2017

329-345

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2 September 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrd4433

2 September 2017

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cites work

Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?

1 reference

Hydrogen sulfide is a signaling molecule and a cytoprotectant

31 March 2020

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Evolutionary and comparative aspects of nitric oxide, carbon monoxide and hydrogen sulfide

31 March 2020

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Structural insights into pathogenic mutations in heme-dependent cystathionine-beta-synthase

31 March 2020

1 reference

Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease

31 March 2020

1 reference

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

31 March 2020

1 reference

Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1

31 March 2020

1 reference

Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticals

31 March 2020

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Free and acid-labile hydrogen sulfide concentrations in mouse tissues: anomalously high free hydrogen sulfide in aortic tissue.

31 March 2020

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Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide

31 March 2020

1 reference

The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.

31 March 2020

1 reference

The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener

31 March 2020

1 reference

Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.

31 March 2020

1 reference

The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma

31 March 2020

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The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver

31 March 2020

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Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon.

31 March 2020

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Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats

31 March 2020

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Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract

31 March 2020

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Sequence of cDNA for rat cystathionine gamma-lyase and comparison of deduced amino acid sequence with related Escherichia coli enzymes

31 March 2020

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Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

31 March 2020

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The possible role of hydrogen sulfide as an endogenous neuromodulator.

31 March 2020

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Expression of the cystathionine beta synthase (CBS) gene during mouse development and immunolocalization in adult brain.

31 March 2020

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Hydrogen sulfide and the pathogenesis of atherosclerosis

31 March 2020

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The message in the air: hydrogen sulfide metabolism in chronic respiratory diseases

31 March 2020

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Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

31 March 2020

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H₂S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase

31 March 2020

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Is cystathionine gamma-lyase protein expressed in the heart?

31 March 2020

1 reference

Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis

31 March 2020

1 reference

3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain

31 March 2020

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Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide.

31 March 2020

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Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A

31 March 2020

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Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production

31 March 2020

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Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells

31 March 2020

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Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms

31 March 2020

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H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal K(ATP) channel

31 March 2020

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Hydrogen sulphide in the hypothalamus causes an ATP-sensitive K+ channel-dependent decrease in blood pressure in freely moving rats.

31 March 2020

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Hydrogen sulfide protects HT22 neuronal cells from oxidative stress

31 March 2020

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Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels

31 March 2020

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Role of KATP channels and TRPV1 receptors in hydrogen sulfide-enhanced gastric emptying of liquid in awake mice.

31 March 2020

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Molecular mechanism for H(2)S-induced activation of K(ATP) channels

31 March 2020

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Hydrogen sulfide as an allosteric modulator of ATP-sensitive potassium channels in colonic inflammation

31 March 2020

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Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells

31 March 2020

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Hydrogen sulfide inhibits L-type calcium currents depending upon the protein sulfhydryl state in rat cardiomyocytes

31 March 2020

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Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels

31 March 2020

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Role of calcium channels in the protective effect of hydrogen sulfide in rat cardiomyoblasts.

31 March 2020

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Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells

31 March 2020

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Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels

31 March 2020

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H₂S is an endothelium-derived hyperpolarizing factor.

31 March 2020

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Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels

31 March 2020

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Hydrogen sulfide inhibits human BK(Ca) channels

31 March 2020

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A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels

31 March 2020

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Hydrogen sulfide increases calcium-activated potassium (BK) channel activity of rat pituitary tumor cells

31 March 2020

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Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca²⁺-activated K⁺ channels and smooth muscle Ca²⁺ sparks

31 March 2020

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Evidence that endogenous hydrogen sulfide exerts an excitatory effect on gastric motility in mice

31 March 2020

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4-aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery.

31 March 2020

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Interaction of hydrogen sulfide with ion channels

31 March 2020

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Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity.

31 March 2020

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Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation

31 March 2020

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Shared signaling pathways among gasotransmitters

31 March 2020

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Hydrogen sulfide inhibits plasma renin activity

31 March 2020

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Hydrogen sulfide regulates intracellular Ca2+ concentration in endothelial cells from excised rat aorta.

31 March 2020

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Modulation of Ca(2+) signalling in human vascular endothelial cells by hydrogen sulfide

31 March 2020

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Hydrogen sulfide activates Ca²⁺ sparks to induce cerebral arteriole dilatation.

31 March 2020

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The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide

31 March 2020

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Detection of protein S-sulfhydration by a tag-switch technique.

31 March 2020

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Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions

31 March 2020

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NOS2 regulation of NF-kappaB by S-nitrosylation of p65.

31 March 2020

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Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function

31 March 2020

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Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies.

31 March 2020

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Characterization of patient mutations in human persulfide dioxygenase (ETHE1) involved in H2S catabolism

31 March 2020

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Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells

31 March 2020

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Interaction of methylglyoxal and hydrogen sulfide in rat vascular smooth muscle cells

31 March 2020

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Supression of hemin-mediated oxidation of low-density lipoprotein and subsequent endothelial reactions by hydrogen sulfide (H(2)S).

31 March 2020

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Hydrogen sulfide protects amyloid-β induced cell toxicity in microglia.

31 March 2020

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Hydrogen sulfide protects against vascular remodeling from endothelial damage

31 March 2020

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Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway

31 March 2020

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AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

31 March 2020

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H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase

31 March 2020

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Hydrogen sulfide is an endogenous stimulator of angiogenesis.

31 March 2020

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Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung

31 March 2020

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Hydrogen sulfide mediates hypoxic vasoconstriction through a production of mitochondrial ROS in trout gills

31 March 2020

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Sulfide, the first inorganic substrate for human cells

31 March 2020

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Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

31 March 2020

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Hydrogen sulfide as an oxygen sensor

31 March 2020

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The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats.

31 March 2020

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Hydrogen sulphide vasodilates human pulmonary arteries: a possible role in pulmonary hypertension?

31 March 2020

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Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics.

31 March 2020

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H(2)S-induced vasorelaxation and underlying cellular and molecular mechanisms

31 March 2020

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Modulation of endogenous production of H2S in rat tissues

31 March 2020

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Impact of L-arginine on hydrogen sulfide/cystathionine-gamma-lyase pathway in rats with high blood flow-induced pulmonary hypertension.

31 March 2020

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Hydrogen sulfide regulates lung tissue-oxidized glutathione and total antioxidant capacity in hypoxic pulmonary hypertensive rats

31 March 2020

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Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia.

31 March 2020

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Hydrogen sulfide attenuates sFlt1-induced hypertension and renal damage by upregulating vascular endothelial growth factor

31 March 2020

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Crosstalk between hydrogen sulfide and nitric oxide in endothelial cells

31 March 2020

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Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice

31 March 2020

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Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis

31 March 2020

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The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-/-) mice

31 March 2020

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Hydrogen sulfide inhibits the development of atherosclerosis with suppressing CX3CR1 and CX3CL1 expression

31 March 2020

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Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia.

31 March 2020

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Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver.

31 March 2020

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A critical life-supporting role for cystathionine γ-lyase in the absence of dietary cysteine supply

31 March 2020

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Relationship between hydrogen sulfide levels and HDL-cholesterol, adiponectin, and potassium levels in the blood of healthy subjects.

31 March 2020

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The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis

31 March 2020

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Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats

31 March 2020

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Curative effects of hydrogen sulfide against acetaminophen-induced hepatotoxicity in mice

31 March 2020

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Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse

31 March 2020

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Hydrogen sulfide modulates sinusoidal constriction and contributes to hepatic microcirculatory dysfunction during endotoxemia.

31 March 2020

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Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats

31 March 2020

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Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes

31 March 2020

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H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells

31 March 2020

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Reduced plasma total homocysteine concentrations in Type 1 diabetes mellitus is determined by increased renal clearance

31 March 2020

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Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis

31 March 2020

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The pathogenic role of cystathionine γ-lyase/hydrogen sulfide in streptozotocin-induced diabetes in mice

31 March 2020

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Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide

31 March 2020

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Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications

31 March 2020

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Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function

31 March 2020

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Hydrogen sulfide improves wound healing via restoration of endothelial progenitor cell functions and activation of angiopoietin-1 in type 2 diabetes

31 March 2020

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Exogenous hydrogen sulfide attenuates diabetic myocardial injury through cardiac mitochondrial protection

31 March 2020

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Brain hydrogen sulfide is severely decreased in Alzheimer's disease

31 March 2020

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Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in β-amyloid rat model of Alzheimer's disease

31 March 2020

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Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in rats.

31 March 2020

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Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models.

31 March 2020

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Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease

31 March 2020

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A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury.

31 March 2020

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5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory Hypersensitivity

31 March 2020

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Luminal hydrogen sulfide plays a pronociceptive role in mouse colon

31 March 2020

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Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat.

31 March 2020

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Role of hydrogen sulfide in the formalin-induced orofacial pain in rats

31 March 2020

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Safety, tolerability and pharmacokinetics of trimebutine 3-thiocarbamoylbenzenesulfonate (GIC-1001) in a randomized phase I integrated design study: single and multiple ascending doses and effect of food in healthy volunteers

31 March 2020

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Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs

31 March 2020

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Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract

31 March 2020

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Gastroprotective effect of NaHS against mucosal lesions induced by ischemia-reperfusion injury in rat

31 March 2020

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Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation

31 March 2020

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Internalization of fluorescent vasotocin-receptor agonist and antagonist in the toad bladder

31 March 2020

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NSAID-gastroenteropathy: new aspects of pathogenesis and prevention

31 March 2020

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Gas mediators involved in modulating duodenal HCO3(-) secretion

31 March 2020

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Gastrointestinal Safety and Anti-Inflammatory Effects of a Hydrogen Sulfide–Releasing Diclofenac Derivative in the Rat

31 March 2020

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Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative

31 March 2020

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Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346).

31 March 2020

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Gastrointestinal-sparing effects of novel NSAIDs in rats with compromised mucosal defence

31 March 2020

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Hydrogen sulfide-releasing anti-inflammatory drugs

31 March 2020

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Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury

31 March 2020

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Hydrogen sulfide enhances ulcer healing in rats

31 March 2020

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Cytoprotective effects of hydrogen sulfide in novel rat models of non-erosive esophagitis.

31 March 2020

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Polypharmacy of osteoarthritis: the perfect intestinal storm

31 March 2020

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Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota.

31 March 2020

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Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism

31 March 2020

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Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis

31 March 2020

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Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis

31 March 2020

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Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase

31 March 2020

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Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein

31 March 2020

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Cystathionine beta-synthase is enriched in the brains of Down's patients.

31 March 2020

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Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme.

31 March 2020

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H2S induces a suspended animation-like state in mice

31 March 2020

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Hydrogen sulphide and its therapeutic potential

31 March 2020

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Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy

31 March 2020

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Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials

31 March 2020

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NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model

31 March 2020

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Anti-cancer activity of new designer hydrogen sulfide-donating hybrids

31 March 2020

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The Incidence of Irritable Bowel Syndrome in Children Using the Rome III Criteria and the Effect of Trimebutine Treatment.

31 March 2020

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Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function

31 March 2020

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Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide

31 March 2020

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GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.

31 March 2020

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The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells.

31 March 2020

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Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.

31 March 2020

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H2S during circulatory shock: some unresolved questions

31 March 2020

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A practical look at the chemistry and biology of hydrogen sulfide

31 March 2020

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Analytical measurement of discrete hydrogen sulfide pools in biological specimens

31 March 2020

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Plasma free H2S levels are elevated in patients with cardiovascular disease.

31 March 2020

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Cystathionine γ-lyase protects against renal ischemia/reperfusion by modulating oxidative stress

31 March 2020

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Cystathionine γ-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure

31 March 2020

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Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury

31 March 2020

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Eukaryotic and prokaryotic contributions to colonic hydrogen sulfide synthesis

31 March 2020

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Detoxification of H(2)S by differentiated colonic epithelial cells: implication of the sulfide oxidizing unit and of the cell respiratory capacity

31 March 2020

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Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production.

31 March 2020

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Metabolic niche of a prominent sulfate-reducing human gut bacterium

31 March 2020

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Polysulfides as intermediates in the oxidation of sulfide to sulfate by Beggiatoa spp

31 March 2020

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Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values

31 March 2020

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Contribution of dietary protein to sulfide production in the large intestine: an in vitro and a controlled feeding study in humans

31 March 2020

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Sulphide impairment of substrate oxidation in rat colonocytes: a biochemical basis for ulcerative colitis?

31 March 2020

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Evidence that hydrogen sulfide is a genotoxic agent.

31 March 2020

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Butyrate-stimulated H2S production in colon cancer cells

31 March 2020

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Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments

31 March 2020

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Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH).

31 March 2020

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12 December 2020

Hydrogen sulfide protects against amyloid beta-peptide induced neuronal injury via attenuating inflammatory responses in a rat model

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12 December 2020

H2S signals through protein S-sulfhydration

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12 December 2020

Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-direct

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12 December 2020

Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage-implications for the treatment of osteoporosis.

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12 December 2020

Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process

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12 December 2020

Endogenous H2S is involved in the development of spontaneous hypertension

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12 December 2020

Effect of hydrogen sulphide on beta-amyloid-induced damage in PC12 cells.

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12 December 2020

Identifiers

DOI

10.1038/NRD4433

1 reference

2 September 2017

1 reference

PubMed ID

25849904