(Q38420827)

2 September 2017

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title

Bioresponsive probes for molecular imaging: concepts and in vivo applications (English)

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2 September 2017

author name string

Sander M J van Duijnhoven

1

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2 September 2017

Marc S Robillard

2

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2 September 2017

Sander Langereis

3

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2 September 2017

Holger Grüll

4

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2 September 2017

language of work or name

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15 April 2015

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Contrast Media & Molecular Imaging

2 September 2017

published in

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2 September 2017

volume

10

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2 September 2017

issue

4

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2 September 2017

page(s)

282-308

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Molecular imaging: the vision and opportunity for radiology in the future

2 September 2017

cites work

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21 January 2018

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Imaging in the era of molecular oncology

21 January 2018

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Molecular imaging: current status and emerging strategies

21 January 2018

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In vivo pathology: seeing with molecular specificity and cellular resolution in the living body

21 January 2018

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Molecular imaging in drug development

21 January 2018

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Molecular Imaging: Looking at Problems, Seeing Solutions

21 January 2018

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Nanotheranostics and image-guided drug delivery: current concepts and future directions

21 January 2018

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Current concepts and future perspectives on surgical optical imaging in cancer

21 January 2018

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Rapid cancer detection by topically spraying a γ-glutamyltranspeptidase-activated fluorescent probe

21 January 2018

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New technologies for human cancer imaging

21 January 2018

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Imaging probes targeting matrix metalloproteinases

21 January 2018

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Strategies for in vivo imaging of enzyme activity: an overview and recent advances

21 January 2018

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Acoustic and photoacoustic molecular imaging of cancer

21 January 2018

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Proteolysis: a biological process adapted in drug delivery, therapy, and imaging.

21 January 2018

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Fluorescent probes for proteolysis: tools for drug discovery

21 January 2018

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Fluorescent chemosensors based on spiroring-opening of xanthenes and related derivatives.

21 January 2018

1 reference

Characterization of human adenovirus proteinase activity in disrupted virus particles

21 January 2018

1 reference

Ala-Pro-cresyl violet, a synthetic fluorogenic substrate for the analysis of kinetic parameters of dipeptidyl peptidase IV (CD26) in individual living rat hepatocytes

21 January 2018

1 reference

Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate

21 January 2018

1 reference

Mechanism of a genetically encoded dark-to-bright reporter for caspase activity

21 January 2018

1 reference

Design and synthesis of rhodamine 110 derivative and caspase-3 substrate for enzyme and cell-based fluorescent assay

21 January 2018

1 reference

Detection and cellular imaging of human cancer enzyme using a turn-on, wavelength-shiftable, self-immolative profluorophore.

21 January 2018

1 reference

Shedding light onto live molecular targets

21 January 2018

1 reference

In vivo imaging of tumors with protease-activated near-infrared fluorescent probes

21 January 2018

1 reference

Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT).

21 January 2018

1 reference

Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis

21 January 2018

1 reference

A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe

21 January 2018

1 reference

Molecular imaging of Cathepsin E-positive tumors in mice using a novel protease-activatable fluorescent probe.

21 January 2018

1 reference

In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas

21 January 2018

1 reference

Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter

21 January 2018

1 reference

Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model

21 January 2018

1 reference

In vivo molecular target assessment of matrix metalloproteinase inhibition

21 January 2018

1 reference

Molecular imaging of MMP expression and therapeutic MMP inhibition

21 January 2018

1 reference

Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction

21 January 2018

1 reference

Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice

21 January 2018

1 reference

In vivo imaging of tissue-remodeling activity involving infiltration of macrophages by a systemically administered protease-activatable probe in colon cancer tissues

21 January 2018

1 reference

Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents

21 January 2018

1 reference

A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo.

21 January 2018

1 reference

Infrared optical imaging of matrix metalloproteinases (MMPs) up regulation following ischemia reperfusion is ameliorated by hypothermia

21 January 2018

1 reference

Optical tomography of MMP activity allows a sensitive noninvasive characterization of the invasiveness and angiogenesis of SCC xenografts

21 January 2018

1 reference

Performance of a new fluorescence-labeled MMP inhibitor to image tumor MMP activity in vivo in comparison to an MMP-activatable probe

21 January 2018

1 reference

Optical tomographic imaging of near infrared imaging agents quantifies disease severity and immunomodulation of experimental autoimmune encephalomyelitis in vivo

21 January 2018

1 reference

Enzyme-activatable imaging probe reveals enhanced neutrophil elastase activity in tumors following photodynamic therapy

21 January 2018

1 reference

Matrix metalloproteinase-assisted triggered release of liposomal contents

21 January 2018

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Mechanistic studies of the triggered release of liposomal contents by matrix metalloproteinase-9.

21 January 2018

1 reference

Design and synthesis of a near-infrared fluorescent nanofiber precursor for detecting cell-secreted urokinase activity

21 January 2018

1 reference

Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe

21 January 2018

1 reference

Indocyanine green encapsulated nanogels for hyaluronidase activatable and selective near infrared imaging of tumors and lymph nodes

21 January 2018

1 reference

Novel mutant green fluorescent protein protease substrates reveal the activation of specific caspases during apoptosis.

21 January 2018

1 reference

Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering

21 January 2018

1 reference

Detection of MMP activity in living cells by a genetically encoded surface-displayed FRET sensor

21 January 2018

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Fluorescence imaging to assess the matrix metalloproteinase activity and its inhibitor in vivo

21 January 2018

1 reference

Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

21 January 2018

1 reference

Developing a peptide-based near-infrared molecular probe for protease sensing

21 January 2018

1 reference

Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity

21 January 2018

1 reference

Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo.

21 January 2018

1 reference

Application of near-infrared fluorescence imaging using a polymeric nanoparticle-based probe for the diagnosis and therapeutic monitoring of colon cancer

21 January 2018

1 reference

Hybrid ferritin nanoparticles as activatable probes for tumor imaging

21 January 2018

1 reference

Imaging of specific activation of photodynamic molecular beacons in breast cancer vertebral metastases

21 January 2018

1 reference

Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.

21 January 2018

1 reference

Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressions

21 January 2018

1 reference

Real-time video imaging of protease expression in vivo

21 January 2018

1 reference

In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity

21 January 2018

1 reference

Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity

21 January 2018

1 reference

Activatable near-infrared fluorescent probe for in vivo imaging of fibroblast activation protein-alpha

21 January 2018

1 reference

Radioactive smart probe for potential corrected matrix metalloproteinase imaging

21 January 2018

1 reference

In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis

21 January 2018

1 reference

Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis.

21 January 2018

1 reference

Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis

21 January 2018

1 reference

An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging

21 January 2018

1 reference

Caspase-activated cell-penetrating peptides reveal temporal coupling between endosomal release and apoptosis in an RGC-5 cell model

21 January 2018

1 reference

Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe

21 January 2018

1 reference

DNase-activatable fluorescence probes visualizing the degradation of exogenous DNA in living cells.

21 January 2018

1 reference

Dynamic imaging of protease activity with fluorescently quenched activity-based probes.

21 January 2018

1 reference

A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages

21 January 2018

1 reference

Energy transfer-based multiplexed assay of proteases by using gold nanoparticle and quantum dot conjugates on a surface

21 January 2018

1 reference

Protease-activated quantum dot probes.

21 January 2018

1 reference

Near-infrared fluorescent proteins for multicolor in vivo imaging

21 January 2018

1 reference

Noninvasive near-infrared fluorescent protein-based imaging of tumor progression and metastases in deep organs and intraosseous tissues

21 January 2018

1 reference

Quantum dots for live cells, in vivo imaging, and diagnostics

21 January 2018

1 reference

Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy.

21 January 2018

1 reference

Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe

21 January 2018

1 reference

Renal clearance of quantum dots

21 January 2018

1 reference

Activatable photosensitizers for imaging and therapy.

21 January 2018

1 reference

Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation

21 January 2018

1 reference

Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation

21 January 2018

1 reference

Photodynamic molecular beacon triggered by fibroblast activation protein on cancer-associated fibroblasts for diagnosis and treatment of epithelial cancers

21 January 2018

1 reference

Photodynamic therapy of cancer: an update

21 January 2018

1 reference

Firefly bioluminescence: a mechanistic approach of luciferase catalyzed reactions.

21 January 2018

1 reference

Luminescent imaging of beta-galactosidase activity in living subjects using sequential reporter-enzyme luminescence

21 January 2018

1 reference

In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis.

21 January 2018

1 reference

In vivo bioluminescence imaging of furin activity in breast cancer cells using bioluminogenic substrates.

21 January 2018

1 reference

A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice.

21 January 2018

1 reference

Latent luciferase activity in the fruit fly revealed by a synthetic luciferin

21 January 2018

1 reference

Green fluorescent protein as a noninvasive intracellular pH indicator

21 January 2018

1 reference

Fluorescent indicators for intracellular pH.

21 January 2018

1 reference

Near infrared fluorescence-based bacteriophage particles for ratiometric pH imaging

21 January 2018

1 reference

Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface-grafted poly(ethylene glycol).

21 January 2018

1 reference

Stimuli-responsive polypeptide vesicles by conformation-specific assembly.

21 January 2018

1 reference

pH-stimuli-responsive near-infrared optical imaging nanoprobe based on poly(γ-glutamic acid)/poly(β-amino ester) nanoparticles

21 January 2018

1 reference

Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes

21 January 2018

1 reference

High sensitivity detection of cancer in vivo using a dual-controlled activation fluorescent imaging probe based on H-dimer formation and pH activation

21 January 2018

1 reference

Near-infrared pH-activatable fluorescent probes for imaging primary and metastatic breast tumors

21 January 2018

1 reference

TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors

21 January 2018

1 reference

Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging.

21 January 2018

1 reference

A coumarin-indole-based near-infrared ratiometric pH probe for intracellular fluorescence imaging.

21 January 2018

1 reference

Imaging acidosis in tumors using a pH-activated near-infrared fluorescence probe

21 January 2018

1 reference

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

21 January 2018

1 reference

The common biology of cancer and ageing

21 January 2018

1 reference

The role of oxidants and free radicals in reperfusion injury

21 January 2018

1 reference

New strategies for fluorescent probe design in medical diagnostic imaging

21 January 2018

1 reference

A selective, cell-permeable optical probe for hydrogen peroxide in living cells

21 January 2018

1 reference

Boronate-based fluorescent probes for imaging cellular hydrogen peroxide

21 January 2018

1 reference

Molecular imaging of hydrogen peroxide produced for cell signaling

21 January 2018

1 reference

Development of a highly sensitive fluorescence probe for hydrogen peroxide.

21 January 2018

1 reference

A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells

21 January 2018

1 reference

Development of a terbium complex-based luminescent probe for imaging endogenous hydrogen peroxide generation in plant tissues.

21 January 2018

1 reference

Nanoencapsulation method for high selectivity sensing of hydrogen peroxide inside live cells

21 January 2018

1 reference

Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation

21 January 2018

1 reference

Synthetic fluorescent probes for imaging of peroxynitrite and hypochlorous acid in living cells

21 January 2018

1 reference

BODIPY-based fluorescent probe for peroxynitrite detection and imaging in living cells.

21 January 2018

1 reference

A design of fluorescent probes for superoxide based on a nonredox mechanism

21 January 2018

1 reference

Design of a phosphinate-based fluorescent probe for superoxide detection in mouse peritoneal macrophages

21 January 2018

1 reference

Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs

21 January 2018

1 reference

Visualization of nitric oxide in living cells by a copper-based fluorescent probe

21 January 2018

1 reference

Cell-trappable fluorescent probes for nitric oxide visualization in living cells

21 January 2018

1 reference

Ratiometric coumarin-neutral red (CONER) nanoprobe for detection of hydroxyl radicals

21 January 2018

1 reference

A FRET-based approach to ratiometric fluorescence detection of hydrogen peroxide

21 January 2018

1 reference

An ICT-based approach to ratiometric fluorescence imaging of hydrogen peroxide produced in living cells.

21 January 2018

1 reference

Superoxide flashes in single mitochondria

21 January 2018

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In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles.

21 January 2018

1 reference

In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter

21 January 2018

1 reference

Strategy for dual-analyte luciferin imaging: in vivo bioluminescence detection of hydrogen peroxide and caspase activity in a murine model of acute inflammation

21 January 2018

1 reference

In vivo targeting of hydrogen peroxide by activatable cell-penetrating peptides.

21 January 2018

1 reference

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

21 January 2018

1 reference

In vivo imaging of the dynamics of glucose uptake in the cytosol of COS-7 cells by fluorescent nanosensors

21 January 2018

1 reference

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin

21 January 2018

1 reference

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

21 January 2018

1 reference

Reengineering of a fluorescent zinc sensor protein yields the first genetically encoded cadmium probe

21 January 2018

1 reference

Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration

21 January 2018

1 reference

Visualizing the dynamics of viral replication in living cells via Tat peptide delivery of nuclease-resistant molecular beacons

21 January 2018

1 reference

Micelle-based activatable probe for in vivo near-infrared optical imaging of cancer biomolecules

21 January 2018

1 reference

Liposomal encapsulation of a near-infrared fluorophore enhances fluorescence quenching and reliable whole body optical imaging upon activation in vivo

21 January 2018

1 reference

FRET-based imaging of transbilayer movement of pepducin in living cells by novel intracellular bioreductively activatable fluorescent probes

21 January 2018

1 reference

Galactosyl human serum albumin-NMP1 conjugate: a near infrared (NIR)-activatable fluorescence imaging agent to detect peritoneal ovarian cancer metastases

21 January 2018

1 reference

An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery.

21 January 2018

1 reference

Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe

21 January 2018

1 reference

Fluorescence lifetime measurements and biological imaging

21 January 2018

1 reference

In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium

21 January 2018

1 reference

Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathology

21 January 2018

1 reference

Optical coherence tomography: a review of clinical development from bench to bedside

21 January 2018

1 reference

Advances in endoscopic imaging of colorectal neoplasia

21 January 2018

1 reference

Near-infrared fluorescence-guided resection of colorectal liver metastases

21 January 2018

1 reference

Comparison of the indocyanine green fluorescence and blue dye methods in detection of sentinel lymph nodes in early-stage breast cancer

21 January 2018

1 reference

The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping

21 January 2018

1 reference

The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction

21 January 2018

1 reference

Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer

21 January 2018

1 reference

Sentinel lymph node detection in skin cancer patients using real-time fluorescence navigation with indocyanine green: preliminary experience.

21 January 2018

1 reference

Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma

21 January 2018

1 reference

Intraoperative near-infrared fluorescence imaging for sentinel lymph node detection in vulvar cancer: first clinical results.

21 January 2018

1 reference

Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer

21 January 2018

1 reference

Intraoperative multispectral fluorescence imaging for the detection of the sentinel lymph node in cervical cancer: a novel concept

21 January 2018

1 reference

Optimization of near-infrared fluorescent sentinel lymph node mapping in cervical cancer patients.

21 January 2018

1 reference

Image-guided cancer surgery using near-infrared fluorescence

21 January 2018

1 reference

Breakthrough in Photonics 2013: Photoacoustic Tomography in Biomedicine

21 January 2018

1 reference

Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques

21 January 2018

1 reference

Design, synthesis, and imaging of an activatable photoacoustic probe

21 January 2018

1 reference

Molecular photoacoustic imaging of follicular thyroid carcinoma.

21 January 2018

1 reference

Visualization of protease activity in vivo using an activatable photo-acoustic imaging probe based on CuS nanoparticles

21 January 2018

1 reference

Photoacoustic lifetime contrast between methylene blue monomers and self-quenched dimers as a model for dual-labeled activatable probes

21 January 2018

1 reference

Photoacoustic lifetime imaging of dissolved oxygen using methylene blue.

21 January 2018

1 reference

In vivo photoacoustic lifetime imaging of tumor hypoxia in small animals

21 January 2018

1 reference

Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications

21 January 2018

1 reference

Activatable T₁ and T₂ magnetic resonance imaging contrast agents

21 January 2018

1 reference

Smart MR imaging agents relevant to potential neurologic applications

21 January 2018

1 reference

A review of responsive MRI contrast agents: 2005-2014

21 January 2018

1 reference

Mechanistic investigation of beta-galactosidase-activated MR contrast agents.

21 January 2018

1 reference

Photochromically-controlled, reversibly-activated MRI and optical contrast agent

21 January 2018

1 reference

In vivo imaging with a cell-permeable porphyrin-based MRI contrast agent

21 January 2018

1 reference

pH-Sensitive polymeric micelle-based pH probe for detecting and imaging acidic biological environments

21 January 2018

1 reference

Novel pH-sensitive paramagnetic liposomes with improved MR properties

21 January 2018

1 reference

Gadolinium-encapsulating iron oxide nanoprobe as activatable NMR/MRI contrast agent

21 January 2018

1 reference

Enzyme-Activated Gd3+ Magnetic Resonance Imaging Contrast Agents with a Prominent Receptor-Induced Magnetization Enhancement.

21 January 2018

1 reference

A Gd3+-based magnetic resonance imaging contrast agent sensitive to beta-galactosidase activity utilizing a receptor-induced magnetization enhancement (RIME) phenomenon.

21 January 2018

1 reference

Synthesis and characterization of a new bioactivated paramagnetic gadolinium(III) complex [Gd(DOTA-FPG)(H2O)] for tracing gene expression

21 January 2018

1 reference

A new gadolinium-based MRI zinc sensor

21 January 2018

1 reference

Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.

21 January 2018

1 reference

Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity

21 January 2018

1 reference

Superparamagnetic iron oxide nanoparticle probes for molecular imaging.

21 January 2018

1 reference

Proteolytic actuation of nanoparticle self-assembly

21 January 2018

1 reference

Nanoparticle self-assembly gated by logical proteolytic triggers

21 January 2018

1 reference

Protease-specific nanosensors for magnetic resonance imaging.

21 January 2018

1 reference

Calcium-sensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin

21 January 2018

1 reference

Magnetic relaxation switches capable of sensing molecular interactions

21 January 2018

1 reference

DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents

21 January 2018

1 reference

Release activation of iron oxide nanoparticles: (REACTION) a novel environmentally sensitive MRI paradigm

21 January 2018

1 reference

Alternatives to gadolinium-based metal chelates for magnetic resonance imaging

21 January 2018

1 reference

Detection of in vivo enzyme activity with CatalyCEST MRI.

21 January 2018

1 reference

A redox-activated MRI contrast agent that switches between paramagnetic and diamagnetic states

21 January 2018

1 reference

Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications

21 January 2018

1 reference

Preparation and in vitro evaluation of a novel amphiphilic GdPCTA-[12] derivative; a micellar MRI contrast agent.

21 January 2018

1 reference

Novel pH-reporter MRI contrast agents

21 January 2018

1 reference

Dendritic PARACEST contrast agents for magnetic resonance imaging

21 January 2018

1 reference

A PARACEST MRI contrast agent to detect enzyme activity.

21 January 2018

1 reference

A paramagnetic MRI-CEST agent responsive to lactate concentration

21 January 2018

1 reference

Calcium-responsive paramagnetic CEST agents

21 January 2018

1 reference

Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors

21 January 2018

1 reference

Design and characterization of a new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide

21 January 2018

1 reference

A paramagnetic CEST agent for imaging glucose by MRI.

21 January 2018

1 reference

Modulation of CEST images in vivo by T1 relaxation: a new approach in the design of responsive PARACEST agents

21 January 2018

1 reference

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

21 January 2018

1 reference

In vivo and in vitro liver cancer metabolism observed with hyperpolarized [5-(13)C]glutamine.

21 January 2018

1 reference

Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate

21 January 2018

1 reference

Activatable imaging probes with amplified fluorescent signals

21 January 2018

1 reference

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

21 January 2018

1 reference

Tissue-penetrating delivery of compounds and nanoparticles into tumors

21 January 2018

1 reference

Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi

21 January 2018

1 reference

Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis.

21 January 2018

1 reference

Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent

21 January 2018

1 reference

Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction

21 January 2018

1 reference

Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.

21 January 2018

1 reference

Activation and retention: a magnetic resonance probe for the detection of acute thrombosis

21 January 2018

1 reference

MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch

21 January 2018

1 reference

FDG accumulation and tumor biology

21 January 2018

1 reference

[18F]FLT-PET in oncology: current status and opportunities

21 January 2018

1 reference

18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients

21 January 2018

1 reference

FLT PET-CT in evaluation of treatment response.

21 January 2018

1 reference

A boronate-caged [¹⁸F]FLT probe for hydrogen peroxide detection using positron emission tomography

21 January 2018

1 reference

Quantitative imaging of disease signatures through radioactive decay signal conversion

21 January 2018

1 reference

SPECT imaging of herpes simplex virus type1 thymidine kinase gene expression by [(123)I]FIAU(1).

21 January 2018

1 reference

Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas

21 January 2018

1 reference

Glioblastoma multiforme: State of the art and future therapeutics

21 January 2018

1 reference

A general approach for the development of fluorogenic probes suitable for no-wash imaging of kinases in live cells

21 January 2018

1 reference

⁹⁹mTc-(Me)FGCDEVD, a potential tracer for apoptosis detection

21 January 2018

1 reference

Targeted imaging and proteomic analysis of tumor-associated glycans in living animals.

21 January 2018

1 reference

Imaging cell surface glycans with bioorthogonal chemical reporters

21 January 2018

1 reference

Imaging cell surface glycosylation in vivo using "double click" chemistry

21 January 2018

1 reference

In vivo imaging of membrane-associated glycans in developing zebrafish

21 January 2018

1 reference

pH-responsive polymeric micelle based on PEG-poly(β-amino ester)/(amido amine) as intelligent vehicle for magnetic resonance imaging in detection of cerebral ischemic area.

21 January 2018

1 reference

Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo

21 January 2018

1 reference

A novel technology for the imaging of acidic prostate tumors by positron emission tomography

21 January 2018

1 reference

The biological characterization of (99m)Tc-BnAO-NI as a SPECT probe for imaging hypoxia in a sarcoma-bearing mouse model.

21 January 2018

1 reference

Applications of nitroimidazole in vivo hypoxia imaging in ischemic stroke

21 January 2018

1 reference

Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation O

21 January 2018

1 reference

FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial.

21 January 2018

1 reference

A comparison of the behavior of (64)Cu-acetate and (64)Cu-ATSM in vitro and in vivo

21 January 2018

1 reference

Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET.

21 January 2018

1 reference

Synthesis and evaluation of a novel (99m)Tc-labeled bioreductive probe for tumor hypoxia imaging

21 January 2018

1 reference

Development of an oxygen-sensitive degradable peptide probe for the imaging of hypoxia-inducible factor-1-active regions in tumors.

21 January 2018

1 reference

Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model

21 January 2018

1 reference

New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging

21 January 2018

1 reference

In vivo positron emission tomography imaging of protease activity by generation of a hydrophobic product from a noninhibitory protease substrate

21 January 2018

1 reference

Tumor imaging by means of proteolytic activation of cell-penetrating peptides

21 January 2018

1 reference

Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides

21 January 2018

1 reference

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

21 January 2018

1 reference

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

21 January 2018

1 reference

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival

21 January 2018

1 reference

Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides

21 January 2018

1 reference

Tumor targeting of MMP-2/9 activatable cell-penetrating imaging probes is caused by tumor-independent activation

21 January 2018

1 reference

Immobilizing reporters for molecular imaging of the extracellular microenvironment in living animals.

21 January 2018

1 reference

Imaging of MMP activity in postischemic cardiac remodeling using radiolabeled MMP-2/9 activatable peptide probes

21 January 2018

1 reference

Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma

21 January 2018

1 reference

Intracellular cargo delivery by an octaarginine transporter adapted to target prostate cancer cells through cell surface protease activation.

21 January 2018

1 reference

Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency

21 January 2018

1 reference

Development of an optimized activatable MMP-14 targeted SPECT imaging probe.

21 January 2018

1 reference

Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides

21 January 2018

1 reference

"Zipper" molecular beacons: a generalized strategy to optimize the performance of activatable protease probes

21 January 2018

1 reference

In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity

21 January 2018

1 reference

Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation

21 January 2018

1 reference

Protease-modulated cellular uptake of quantum dots

21 January 2018

1 reference

PEGylated and MMP-2 specifically dePEGylated quantum dots: comparative evaluation of cellular uptake

21 January 2018

1 reference

A biocompatible condensation reaction for controlled assembly of nanostructures in living cells.

21 January 2018

1 reference

Activatable oligomerizable imaging agents for photoacoustic imaging of furin-like activity in living subjects

21 January 2018

1 reference

Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation.

21 January 2018

1 reference

A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells

21 January 2018

1 reference

Accurate targeting of activated macrophages based on synergistic activation of functional molecules uptake by scavenger receptor and matrix metalloproteinase.

21 January 2018

1 reference

Semi-synthesis of a protease-activatable collagen targeting probe.

21 January 2018

1 reference

Multispectral photoacoustic imaging of fluorochromes in small animals

21 January 2018

1 reference

Stimuli-Triggered Off/On Switchable Complexation between a Novel Type of Charge-Generation Polymer (CGP) and Gold Nanoparticles for the Sensitive Colorimetric Detection of Hydrogen Peroxide and Glucose

21 January 2018

1 reference

Self-assembled peptide nanoparticles as tumor microenvironment activatable probes for tumor targeting and imaging

21 January 2018

1 reference

Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor

21 January 2018

1 reference

Improved paramagnetic liposomes for MRI visualization of pH triggered release

21 January 2018

1 reference

Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe

21 January 2018

1 reference

7 January 2021

Near-infrared optical imaging of protease activity for tumor detection

1 reference

7 January 2021

Principles of Fluorescence Spectroscopy

1 reference

7 January 2021

In vivo imaging of proteolytic activity in atherosclerosis

1 reference

7 January 2021

In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response

1 reference

7 January 2021

Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes

1 reference

7 January 2021

Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo

1 reference

7 January 2021

In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer.

1 reference

7 January 2021

Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes.

1 reference

7 January 2021

In vivo imaging and biochemical characterization of protease function using fluorescent activity-based probes

1 reference

7 January 2021

Targeted Photodynamic Therapy Agent with a Built-In Apoptosis Sensor for in Vivo Near-Infrared Imaging of Tumor Apoptosis Triggered by its Photosensitization in Situ

1 reference

7 January 2021

A bioluminogenic substrate for in vivo imaging of beta-lactamase activity

1 reference

7 January 2021

Optimized pH-responsive cyanine fluorochromes for detection of acidic environments

1 reference

7 January 2021

Design and synthesis of fluorescent probes for selective detection of highly reactive oxygen species in mitochondria of living cells

1 reference

7 January 2021

A highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cells

1 reference

7 January 2021

Design of a practical fluorescent probe for superoxide based on protection-deprotection chemistry of fluoresceins with benzenesulfonyl protecting groups

1 reference

7 January 2021

Development of a highly specific rhodamine-based fluorescence probe for hypochlorous acid and its application to real-time imaging of phagocytosis

1 reference

7 January 2021

A highly specific BODIPY-based fluorescent probe for the detection of hypochlorous acid

1 reference

7 January 2021

A rhodamine-hydroxamic acid-based fluorescent probe for hypochlorous acid and its applications to biological imagings

1 reference

7 January 2021

Coumarin-3-carboxylic acid as a detector for hydroxyl radicals generated chemically and by gamma radiation

1 reference

7 January 2021

Genetically encoded fluorescent indicator for intracellular hydrogen peroxide

1 reference

7 January 2021

A highly selective fluorescent probe for visualization of organic hydroperoxides in living cells

1 reference

7 January 2021

A Calcium-Sensitive Magnetic Resonance Imaging Contrast Agent

1 reference

7 January 2021

Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion

1 reference

7 January 2021

Dependence of the relaxivity and luminescence of gadolinium and europium amino-acid complexes on hydrogencarbonate and pH

1 reference

7 January 2021

Enzyme-Activated Gd(3+) Magnetic Resonance Imaging Contrast Agents with a Prominent Receptor-Induced Magnetization Enhancement We thank Dr. Shrikumar Nair for helpful discussions

1 reference

7 January 2021

Sulfonamide-Functionalized Gadolinium DTPA Complexes as Possible Contrast Agents for MRI: A Relaxometric Investigation

1 reference

7 January 2021

DTPA-bisamide-based MR sensor agents for peroxidase imaging

1 reference

7 January 2021

Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets

1 reference

7 January 2021

A paramagnetic contrast agent with myeloperoxidase-sensing properties

1 reference

7 January 2021

Magnetic sensors for protease assays

1 reference

7 January 2021

Detection of Enzymatic Activity by PARACEST MRI: A General Approach to Target a Large Variety of Enzymes

1 reference

7 January 2021

Novel pH-sensitive charge-reversal cell penetrating peptide conjugated PEG-PLA micelles for docetaxel delivery: in vitro study

1 reference

7 January 2021

¹⁸F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with ¹⁸F-FMISO

1 reference

7 January 2021

Noninvasive detection of matrix metalloproteinase activity in vivo using a novel magnetic resonance imaging contrast agent with a solubility switch.

1 reference

7 January 2021

Identifiers

DOI

10.1002/CMMI.1636

1 reference

2 September 2017

1 reference