(Q38424675)

3 September 2017

1 reference

title

Gephyrin: a central GABAergic synapse organizer (English)

1 reference

3 September 2017

Gayoung Choii

1

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3 September 2017

Jaewon Ko

series ordinal

2

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3 September 2017

publication date

17 April 2015

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Experimental and Molecular Medicine

3 September 2017

published in

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3 September 2017

volume

47

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3 September 2017

page(s)

e158

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

3 September 2017

copyright license

start time

1 April 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Gephyrin, the enigmatic organizer at GABAergic synapses

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Gephyrin: a master regulator of neuronal function?

21 January 2018

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Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.

21 January 2018

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Gephyrin: where do we stand, where do we go?

21 January 2018

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GABA(A) receptors, gephyrin and homeostatic synaptic plasticity.

21 January 2018

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Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

X-ray crystal structure of the trimeric N-terminal domain of gephyrin

21 January 2018

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Deciphering the structural framework of glycine receptor anchoring by gephyrin

21 January 2018

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Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C

21 January 2018

1 reference

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Vertebrate-specific sequences in the gephyrin E-domain regulate cytosolic aggregation and postsynaptic clustering

21 January 2018

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Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model

21 January 2018

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Structural basis of dynamic glycine receptor clustering by gephyrin

21 January 2018

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Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMM.2015.5

Mass spectrometric analysis of glycine receptor-associated gephyrin splice variants

21 January 2018

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CLIP identifies Nova-regulated RNA networks in the brain

21 January 2018

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HITS-CLIP yields genome-wide insights into brain alternative RNA processing

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMM.2015.5

Expression and subcellular distribution of gephyrin in non-neuronal tissues and cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Splice-specific glycine receptor binding, folding, and phosphorylation of the scaffolding protein gephyrin

21 January 2018

1 reference

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Diversity and phylogeny of gephyrin: tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins

21 January 2018

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Localization of the clustering protein gephyrin at GABAergic synapses in the main olfactory bulb of the rat.

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMM.2015.5

Colocalization of multiple GABA(A) receptor subtypes with gephyrin at postsynaptic sites

21 January 2018

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Localization of gephyrin and glycine receptor subunit immunoreactivity in the rabbit retina

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMM.2015.5

Distribution of gephyrin in the human brain: an immunohistochemical analysis

21 January 2018

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Differential regulation of GABA(A) receptor and gephyrin postsynaptic clustering in immature hippocampal neuronal cultures

21 January 2018

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Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The 93 kDa protein gephyrin and tubulin associated with the inhibitory glycine receptor are phosphorylated by an endogenous protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Gephyrin phosphorylation in the functional organization and plasticity of GABAergic synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Regulation of postsynaptic gephyrin cluster size by protein phosphatase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Identification of a gephyrin binding motif on the glycine receptor beta subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Biochemical characterization of the high affinity binding between the glycine receptor and gephyrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Coexpression of the receptor&#x2010;associated protein gephyrin changes the ligand binding affinities of α2 glycine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Glycine-receptor activation is required for receptor clustering in spinal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Reduced synaptic clustering of GABA and glycine receptors in the retina of the gephyrin null mutant mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Fast and reversible trapping of surface glycine receptors by gephyrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Gephyrin oligomerization controls GlyR mobility and synaptic clustering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Hydrophobic interactions mediate binding of the glycine receptor beta-subunit to gephyrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Distinct gamma2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

GABARAP is not essential for GABA receptor targeting to the synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Structure and potential function of gamma-aminobutyrate type A receptor-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Distribution of transcripts for the brain-specific GDP/GTP exchange factor collybistin in the developing mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Effects of distinct collybistin isoforms on the formation of GABAergic synapses in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

A conformational switch in collybistin determines the differentiation of inhibitory postsynapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Complex role of collybistin and gephyrin in GABAA receptor clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Differential regulation of the postsynaptic clustering of γ-aminobutyric acid type A (GABAA) receptors by collybistin isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Interactions of drebrin and gephyrin with profilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

A human peptidyl-prolyl isomerase essential for regulation of mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Phosphorylation-specific prolyl isomerization: is there an underlying theme?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Neuroligin 2 is exclusively localized to inhibitory synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Control of excitatory and inhibitory synapse formation by neuroligins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Neuroligins and neurexins link synaptic function to cognitive disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Neurexin-1β binding to neuroligin-1 triggers the preferential recruitment of PSD-95 versus gephyrin through tyrosine phosphorylation of neuroligin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Recombinant probes for visualizing endogenous synaptic proteins in living neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Autoimmunity to gephyrin in Stiff-Man syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Mutations in the molybdenum cofactor biosynthetic genesMOCS1, MOCS2, andGEPH

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor, and mutation analysis in hyperekplexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Downregulation of gephyrin in temporal lobe epilepsy neurons in humans and a rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Valproic acid mediates the synaptic excitatory/inhibitory balance through astrocytes--a preliminary study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

Regulation of gephyrin assembly and glycine receptor synaptic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

Functional heterogeneity of gephyrins

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

Distribution of gephyrin transcripts in the adult and developing rat brain

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

Clustering of gephyrin at GABAergic but not glutamatergic synapses in cultured rat hippocampal neurons

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

Targeting of glycine receptor subunits to gephyrin-rich domains in transfected human embryonic kidney cells

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

A GPHN point mutation leading to molybdenum cofactor deficiency

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

Reduced expression of the inhibitory synapse scaffolding protein gephyrin in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.5

7 January 2021

Identifiers

DOI

10.1038/EMM.2015.5

1 reference

Dimensions Publication ID

3 September 2017

1028960536

0 references

Fatcat ID

release_r6kwgsm33ra53dibsz27xmymzi

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/r6kwgsm33ra53dibsz27xmymzi

24 November 2022

mapped directly with Wikidata item

1 reference