(Q38431646)

3 September 2017

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title

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment (English)

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3 September 2017

1 reference

4

Paul Krack

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3 September 2017

2

Jaime Kulisevsky

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3 September 2017

1

Javier Pagonabarraga

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3 September 2017

3

Antonio P Strafella

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3 September 2017

publication date

12 April 2015

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3 September 2017

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3 September 2017

volume

14

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3 September 2017

issue

5

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3 September 2017

page(s)

518-531

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Apathy: a neuropsychiatric syndrome

3 September 2017

cites work

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7 January 2021

Apathy in Parkinson's disease: diagnostic and etiological dilemmas

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7 January 2021

Apathy and depression: separate factors in Parkinson's disease

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Apathy in untreated early-stage Parkinson disease: relationship with other non-motor symptoms

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7 January 2021

Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease

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7 January 2021

Apathy in Parkinson's disease: more than just executive dysfunction

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7 January 2021

Negative symptoms: the 'pathology' of motivation and goal-directed behaviour

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Encoding of aversion by dopamine and the nucleus accumbens.

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Judgment and decision making

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7 January 2021

From motivation to action: functional interface between the limbic system and the motor system.

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7 January 2021

Apathy: a treatable syndrome

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7 January 2021

Dysfunction of fronto-limbic brain circuitry in depression

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7 January 2021

Willed action and its impairments

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7 January 2021

Three before their time: neuroscientists whose ideas were ignored by their contemporaries

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7 January 2021

Pure psychic akinesia with bilateral lesions of basal ganglia

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7 January 2021

Auto-Activation deficit: a basal ganglia related syndrome

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7 January 2021

The anatomical relationships of the prefrontal cortex with limbic structures and the basal ganglia

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7 January 2021

The limbic system: an anatomic, phylogenetic, and clinical perspective

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7 January 2021

Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson's disease

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7 January 2021

Dopamine neuron systems in the brain: an update

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7 January 2021

Neuropsychological and neuroimaging evidence for the involvement of the frontal lobes in depression

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7 January 2021

A final common pathway for depression? Progress toward a general conceptual framework

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7 January 2021

Effect of sertraline on regional metabolic rate in patients with affective disorder

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7 January 2021

Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response.

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7 January 2021

Assessment of the progression of Parkinson's disease: a metabolic network approach

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7 January 2021

Athymhormia and disorders of motivation in Basal Ganglia disease

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7 January 2021

Cognitive and emotional influences in anterior cingulate cortex

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7 January 2021

Emotional processing in anterior cingulate and medial prefrontal cortex

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7 January 2021

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7 January 2021

Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop

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7 January 2021

Functional and anatomical relationships among the amygdala, basal forebrain, ventral striatum, and cortex. An integrative discussion

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7 January 2021

The onset of nonmotor symptoms in Parkinson's disease (the ONSET PD study).

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7 January 2021

The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson's disease

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7 January 2021

The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Apathy in untreated, de novo patients with Parkinson's disease: validation study of Apathy Evaluation Scale

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Characteristics of apathy in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Prevalence and correlates of neuropsychiatric symptoms in Parkinson's disease without dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Apathy in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress

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7 January 2021

Dissociating apathy and depression in Parkinson disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Apathy may herald cognitive decline and dementia in Parkinson's disease

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7 January 2021

Prevalence and clinical correlates of apathy in Parkinson's disease: a community-based study

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7 January 2021

Apathy is associated with activities of daily living ability in Parkinson's disease

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7 January 2021

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

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7 January 2021

Predictors of discrepancies in Parkinson's disease patient and caregiver ratings of apathy, disinhibition, and executive dysfunction before and after diagnosis.

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7 January 2021

Are apathy and depression independently associated with longitudinal trajectories of cortical atrophy in mild cognitive impairment?

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Staging of brain pathology related to sporadic Parkinson's disease

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7 January 2021

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

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7 January 2021

Clinical, neuropsychological, and morphometric correlates of apathy in Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Reliability, validity, and clinical correlates of apathy in Parkinson's disease

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7 January 2021

Apathy and impaired emotional facial recognition networks overlap in Parkinson's disease: a PET study with conjunction analyses.

1 reference

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7 January 2021

Acute effects of levodopa on neuropsychological performance in stable and fluctuating Parkinson's disease patients at different levodopa plasma levels

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: a combined ERP and fMRI study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Apathy in Parkinson's disease: neurophysiological evidence of impaired incentive processing

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Unique effects of apathy and depression signs on cognition and function in amnestic mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Clinical correlates of apathy in patients recently diagnosed with Parkinson's disease: the ANIMO study

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Apathy and anhedonia rating scales in Parkinson's disease: critique and recommendations

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Anxiety rating scales in Parkinson's disease: critique and recommendations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Depression rating scales in Parkinson's disease: critique and recommendations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

The behavioural and motor consequences of focal lesions of the basal ganglia in man.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Loss of psychic self-activation after paramedian bithalamic infarction.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Range of neuropsychiatric disturbances in patients with Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Different apathy profile in behavioral variant of frontotemporal dementia and Alzheimer's disease: a preliminary investigation

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7 January 2021

Neuropsychiatric differences between Parkinson's disease with dementia and Alzheimer's disease

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7 January 2021

Brain perfusion in Alzheimer's disease with and without apathy: a SPECT study with statistical parametric mapping analysis

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7 January 2021

A SPECT study of apathy in Alzheimer's disease

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7 January 2021

Positron emission tomography metabolic correlates of apathy in Alzheimer disease

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7 January 2021

Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients

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7 January 2021

Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation

1 reference

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7 January 2021

Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system

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7 January 2021

Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study

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7 January 2021

Emotion, decision making and the orbitofrontal cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Rotigotine and specific non-motor symptoms of Parkinson's disease: post hoc analysis of RECOVER.

1 reference

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7 January 2021

Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study

1 reference

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7 January 2021

Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD.

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7 January 2021

Clinical features of dopamine agonist withdrawal syndrome in a movement disorders clinic

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7 January 2021

Subthalamic stimulation in Parkinson's disease: restoring the balance of motivated behaviours

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Mood and behavioural effects of subthalamic stimulation in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Dopamine agonist withdrawal syndrome in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Neural bases of set-shifting deficits in Parkinson's disease.

1 reference

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7 January 2021

Cortical activity in Parkinson's disease during executive processing depends on striatal involvement

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Neuroimaging markers of motor and nonmotor features of Parkinson's disease: an 18f fluorodeoxyglucose positron emission computed tomography study.

1 reference

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7 January 2021

Subthalamic nucleus stimulation in Parkinson disease induces apathy: a PET study

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7 January 2021

The apathy inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment.

1 reference

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7 January 2021

Subthalamic nucleus or internal pallidal stimulation in young onset Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Does subthalamic nucleus stimulation induce apathy in Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Postoperative management of deep brain stimulation in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Neurostimulation for Parkinson's Disease with Early Motor Complications

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Does bilateral stimulation of the subthalamic nucleus aggravate apathy in Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Deep brain stimulation of the subthalamic nucleus enhances emotional processing in Parkinson disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Psychostimulant effect of levodopa: reversing sensitisation is possible

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Apathy following subthalamic stimulation in Parkinson disease: a dopamine responsive symptom

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Evidence for impaired presynaptic dopamine function in parkinsonian patients with motor fluctuations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Cognitive decline correlates with neuropathological stage in Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Cognitive status correlates with neuropathologic stage in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Bilateral subthalamic or pallidal stimulation for Parkinson's disease affects neither memory nor executive functions: a consecutive series of 62 patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: a meta-analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson's disease: results from a randomized trial.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Long-term outcomes of surgical therapies for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Pramipexole modulates the neural network of reward anticipation.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Changes in artistic style and behaviour in Parkinson's disease: dopamine and creativity

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: a [11C] FLB-457 and PET study.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: validation in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Cognitive declines one year after unilateral deep brain stimulation surgery in Parkinson's disease: a controlled study using reliable change

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

The syndromal validity and nosological position of apathy in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Validation of diagnostic criteria for apathy in Parkinson’s disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Rivastigmine in apathetic but dementia and depression-free patients with Parkinson's disease: a double-blind, placebo-controlled, randomised clinical trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

The effect of pramipexole on mood and motivational symptoms in Parkinson's disease: a meta-analysis of placebo-controlled studies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Methylphenidate treats apathy in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge

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7 January 2021

Effect of methylphenidate on attention in apathetic AD patients in a randomized, placebo-controlled trial

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7 January 2021

Safety and efficacy of methylphenidate for apathy in Alzheimer's disease: a randomized, placebo-controlled trial

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Methyl phenidate in parkinsonism.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Major depression in Parkinson's disease and the mood response to intravenous methylphenidate: possible role of the "hedonic" dopamine synapse

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Behavioural disorders, Parkinson's disease and subthalamic stimulation

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Are selective serotonin reuptake inhibitors associated with greater apathy in Parkinson's disease?

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https://api.crossref.org/works/10.1016%2FS1474-4422%2815%2900019-8

7 January 2021

Selective serotonin reuptake inhibitor use associates with apathy among depressed elderly: a case-control study

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7 January 2021

Bupropion in the management of apathy.

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7 January 2021

Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging

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7 January 2021

A prospective longitudinal study of apathy in Alzheimer's disease

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7 January 2021

Neuropsychiatric assessment of Gilles de la Tourette patients: comparative study with other hyperkinetic and hypokinetic movement disorders.

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7 January 2021

Apathy is not depression

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7 January 2021

Neuropsychiatric aspects of Huntington's disease.

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7 January 2021

Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease

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7 January 2021

The clinical picture of frontotemporal dementia: diagnosis and follow-up

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7 January 2021

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

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7 January 2021

Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia

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7 January 2021

Neuropsychiatric aspects of progressive supranuclear palsy

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7 January 2021

Apathy is not depression in Huntington's disease

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7 January 2021

Subthalamic nucleus stimulation and compulsive use of dopaminergic medication in Parkinson's disease

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7 January 2021

Apathy in drug-naïve patients with incident Parkinson's disease: the Norwegian ParkWest study.

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7 January 2021

Treating Apathy in Alzheimer’s Disease

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7 January 2021

Pharmacological treatment of apathy in neurodegenerative diseases: a systematic review

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7 January 2021

10.1016/S1474-4422(15)00019-8

Identifiers

DOI

1 reference

3 September 2017

1 reference