(Q38447648)

3 September 2017

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title

Nonalcoholic Fatty liver disease, diabetes, obesity, and hepatocellular carcinoma (English)

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metabolic dysfunction–associated steatotic liver disease

3 September 2017

0 references

1 reference

1 reference

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Mazen Noureddin

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6658171&resulttype=core&format=json

15 May 2020

Mary E Rinella

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6658171&resulttype=core&format=json

15 May 2020

publication date

12 March 2015

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25921668

3 September 2017

published in

Clinics in liver disease

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6658171&resulttype=core&format=json

15 May 2020

volume

19

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6658171&resulttype=core&format=json

15 May 2020

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6658171&resulttype=core&format=json

15 May 2020

page(s)

361-379

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6658171&resulttype=core&format=json

Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury

15 May 2020

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Lipid-rich clear-cell hepatocellular carcinoma arising in non-alcoholic steatohepatitis in a patient with diabetes mellitus.

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The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family.

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Augmentation effect of postprandial hyperinsulinaemia on growth of human hepatocellular carcinoma

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12 December 2020

The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma

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12 December 2020

A central role for JNK in obesity and insulin resistance

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12 December 2020

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

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12 December 2020

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

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Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

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Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

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Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma

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12 December 2020

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Introduction: The burden of hepatocellular carcinoma

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Obesity as a risk factor for hepatocellular carcinoma in a noncirrhotic patient

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Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

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12 December 2020

New insights into leptin resistance by modifying cytokine receptor signal transduction.

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Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma.

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Hepatocellular carcinoma and nonalcoholic steatohepatitis developing during long-term administration of valproic acid

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12 December 2020

Intracellular signalling pathways activated by leptin

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12 December 2020

Liver disease in patients with diabetes mellitus

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JNK1 but not JNK2 promotes the development of steatohepatitis in mice

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12 December 2020

Hepatocellular carcinoma arising from nonalcoholic steatohepatitis: report of two cases

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12 December 2020

Long-term follow-up of patients with NAFLD and elevated liver enzymes

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12 December 2020

Two cases of non-alcoholic steatohepatitis with development of hepatocellular carcinoma without cirrhosis.

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12 December 2020

Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma

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12 December 2020

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Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

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Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies

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12 December 2020

Primary liver cancers with nonalcoholic steatohepatitis

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Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta

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12 December 2020

Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

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12 December 2020

Toll-like receptors and adaptor molecules in liver disease: update

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12 December 2020

The epidemiology of nonalcoholic fatty liver disease: a global perspective

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12 December 2020

Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis?

1 reference

12 December 2020

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

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12 December 2020

Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer

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12 December 2020

Long-term follow-up of patients with nonalcoholic fatty liver

1 reference

12 December 2020

Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis.

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12 December 2020

Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

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12 December 2020

Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH.

1 reference

12 December 2020

Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes

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12 December 2020

The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma

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12 December 2020

Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells.

1 reference

12 December 2020

S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model

1 reference

12 December 2020

Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis

1 reference

12 December 2020

Does hepatocellular carcinoma in non-alcoholic steatohepatitis exist in cirrhotic and non-cirrhotic patients?

1 reference

12 December 2020

Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial

1 reference

12 December 2020

Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link

1 reference

12 December 2020

Narrative review: the role of leptin in human physiology: emerging clinical applications

1 reference

12 December 2020

Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma

1 reference

12 December 2020

Circulating mitochondrial DAMPs cause inflammatory responses to injury

1 reference

12 December 2020

The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

1 reference

12 December 2020

Pattern recognition receptors and inflammation

1 reference

12 December 2020

Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease

1 reference

12 December 2020

Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: our case series and literature review

1 reference

12 December 2020

Prospective study of hepatocellular carcinoma in nonalcoholic steatohepatitis in comparison with hepatocellular carcinoma caused by chronic hepatitis C

1 reference

12 December 2020

Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma

1 reference

12 December 2020

Population-based risk factors and resource utilization for HCC: US perspective

1 reference

12 December 2020

Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents

1 reference

12 December 2020

Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study.

1 reference

12 December 2020

PTEN in liver diseases and cancer

1 reference

12 December 2020

Combined inhibitory effects of celecoxib and fluvastatin on the growth of human hepatocellular carcinoma xenografts in nude mice

1 reference

12 December 2020

Role of nuclear receptor SHP in metabolism and cancer

1 reference

12 December 2020

Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis

1 reference

12 December 2020

Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis.

1 reference

12 December 2020

Hepatocellular carcinomas can develop in simple fatty livers in the setting of oxidative stress.

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12 December 2020

Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation

1 reference

12 December 2020

MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase

1 reference

12 December 2020

JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Δ716) mice.

1 reference

12 December 2020

Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma.

1 reference

12 December 2020

Surgical outcomes for hepatocellular carcinoma in nonalcoholic fatty liver disease

1 reference

12 December 2020

The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study.

1 reference

12 December 2020

Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis

1 reference

12 December 2020

Prognostic role of diabetes mellitus in hepatocellular carcinoma patients after curative treatments: a meta-analysis.

1 reference

12 December 2020

Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis

1 reference

12 December 2020

Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: a population-based cohort study

1 reference

12 December 2020

Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression

1 reference

12 December 2020

Difference in malignancies of chronic liver disease due to non-alcoholic fatty liver disease or hepatitis C in Japanese elderly patients

1 reference

12 December 2020

The role of pre-existing diabetes mellitus on hepatocellular carcinoma occurrence and prognosis: a meta-analysis of prospective cohort studies.

1 reference

12 December 2020

Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.

1 reference

12 December 2020

S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility

1 reference

12 December 2020

S-adenosylmethionine in liver health, injury, and cancer

1 reference

12 December 2020

Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection

1 reference

12 December 2020

Anti-diabetic medications and the risk of hepatocellular cancer: a systematic review and meta-analysis

1 reference

12 December 2020

S-adenosylmethionine metabolism and liver disease.

1 reference

12 December 2020

The mTOR pathway in hepatic malignancies

1 reference

12 December 2020

Population-attributable fractions of risk factors for hepatocellular carcinoma in the United States

1 reference

12 December 2020

NAFLD, NASH and liver cancer

1 reference

12 December 2020

The unfolded protein response in fatty liver disease

1 reference

12 December 2020

The paradox of the unfolded protein response in cancer

1 reference

12 December 2020

Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.

1 reference

12 December 2020

Diabetes mellitus and poorer prognosis in hepatocellular carcinoma: a systematic review and meta-analysis

1 reference

12 December 2020

Controversies in the Diagnosis and Management of NAFLD and NASH.

1 reference

12 December 2020

Statin treatment reduces the risk of hepatocellular carcinoma but not colon cancer-results from a nationwide case-control study in Sweden

1 reference

12 December 2020

Temporal trends of nonalcoholic fatty liver disease-related hepatocellular carcinoma in the veteran affairs population

1 reference

12 December 2020

Obesity and cancer risk: a Danish record-linkage study.

1 reference

12 December 2020

Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product.

1 reference

12 December 2020

Insulin receptor substrate 1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor beta1-induced apoptosis.

1 reference

12 December 2020

Excess risk of primary liver cancer in patients with diabetes mellitus

1 reference

12 December 2020

Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes

1 reference

12 December 2020

Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark.

1 reference

12 December 2020

Implications of the hyperinsulinaemia-diabetes-cancer link for preventive efforts.

1 reference

12 December 2020

10.1016/J.CLD.2015.01.012

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6658171&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6658171&resulttype=core&format=json

15 May 2020

25921668

1 reference