(Q38461606)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds (English)

1 reference

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15 January 2020

2

1 reference

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15 January 2020

7

Gregg B Fields

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Joshua Roth

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Etzer Darout

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Qin Liu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Janelle Lauer

5

1 reference

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15 January 2020

Peter Hodder

6

1 reference

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15 January 2020

William R Roush

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

language of work or name

English

0 references

publication date

22 September 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

Bioorganic & Medicinal Chemistry Letters

15 January 2020

published in

1 reference

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15 January 2020

volume

21

1 reference

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15 January 2020

issue

23

1 reference

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15 January 2020

page(s)

7180-7184

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease

15 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Matrix metalloproteinase proteomics: substrates, targets, and therapy.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Structural bases for substrate and inhibitor recognition by matrix metalloproteinases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Joint diseases and matrix metalloproteinases: a role for MMP-13.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Towards third generation matrix metalloproteinase inhibitors for cancer therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Structural basis for the highly selective inhibition of MMP-13.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3210410

Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

1 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22018790

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Potent, selective pyrimidinetrione-based inhibitors of MMP-13

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22018790

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMCL.2011.09.077

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22018790%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

22018790

1 reference