(Q38525254)

3 September 2017

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title

Therapeutic conotoxins: a US patent literature survey (English)

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3 September 2017

2

1 reference

3 September 2017

Thomas Durek

1

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language of work or name

English

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publication date

12 June 2015

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Expert Opinion on Therapeutic Patents

3 September 2017

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3 September 2017

25

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3 September 2017

10

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3 September 2017

1159-1173

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Conus venoms: a rich source of novel ion channel-targeted peptides

3 September 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Conus venom peptide pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Post-translationally modified neuropeptides from Conus venoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Chemical modification of conotoxins to improve stability and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Ziconotide: neuronal calcium channel blocker for treating severe chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Toxins and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Conopeptide characterization and classifications: an analysis using ConoServer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Peptide neurotoxins from fish-hunting cone snails

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Intrathecal ziconotide: a review of its use in patients with chronic pain refractory to other systemic or intrathecal analgesics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Voltage-gated sodium channels at 60: structure, function and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Sodium channels in normal and pathological pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Painful and painless channelopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

A new family of conotoxins that blocks voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Molecular interaction of delta-conotoxins with voltage-gated sodium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

δ-Conotoxins synthesized using an acid-cleavable solubility tag approach reveal key structural determinants for NaV subtype selectivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Gain-of-function mutations in SCN11A cause familial episodic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

NaN/Nav1.9: a sodium channel with unique properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Conotoxins targeting nicotinic acetylcholine receptors: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Recent advances in Cys-loop receptor structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Heterogeneity and complexity of native brain nicotinic receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Nicotinic ACh receptors as therapeutic targets in CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Limited efficacy of α-conopeptides, Vc1.1 and RgIA, to inhibit sensory neuron CaV current

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABA(B) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Contulakin-G, an O-glycosylated invertebrate neurotensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

A sleep-inducing peptide from Conus geographus venom

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Role of gamma-carboxyglutamic acid in the calcium-induced structural transition of conantokin G, a conotoxin from the marine snail Conus geographus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

In vitro stability of low-concentration ziconotide alone or in admixtures in intrathecal pumps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Establishing regiocontrol of disulfide bond isomers of alpha-conotoxin ImI via the synthesis of N-to-C cyclic analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Biomimetic synthesis of cyclic peptides using novel thioester surrogates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Cyclization of conotoxins to improve their biopharmaceutical properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Cyclization of peptides by using selenolanthionine bridges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Click chemistry in peptide-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

The T-superfamily of conotoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1054095

10.1517/13543776.2015.1054095

21 January 2018

Identifiers

DOI

1 reference

3 September 2017

1 reference

PubMed ID

26065897