(Q38547273)

4 September 2017

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title

Insights into the chemical logic and enzymatic machinery of NRPS assembly lines (English)

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4 September 2017

Christopher T Walsh

1

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4 September 2017

language of work or name

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15 July 2015

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4 September 2017

published in

Natural Product Reports

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4 September 2017

volume

33

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4 September 2017

issue

2

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4 September 2017

page(s)

127-135

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The chemical versatility of natural-product assembly lines

4 September 2017

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A new enzyme superfamily - the phosphopantetheinyl transferases

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Peptidyl transfers in gramicidin S bisoynthesis from enzyme-bound thioester intermediates

21 January 2018

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Interrelation between activation and polymerization in gramicidin S biosynthesis

21 January 2018

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Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product

21 January 2018

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Subcloning of the enterobactin biosynthetic gene entB: expression, purification, characterization, and substrate specificity of isochorismatase.

21 January 2018

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Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine

21 January 2018

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Characterization of EntF as a serine-activating enzyme

21 January 2018

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Enterobactin Biosynthesis in Escherichia coli: Isochorismate Lyase (EntB) Is a Bifunctional Enzyme That Is Phosphopantetheinylated by EntD and Then Acylated by EntE Using ATP and 2,3-Dihydroxybenzoate

21 January 2018

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Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF.

21 January 2018

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Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization.

21 January 2018

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In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities

21 January 2018

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Reconstitution and characterization of the Vibrio cholerae vibriobactin synthetase from VibB, VibE, VibF, and VibH.

21 January 2018

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Vibriobactin biosynthesis in Vibrio cholerae: VibH is an amide synthase homologous to nonribosomal peptide synthetase condensation domains

21 January 2018

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Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.

21 January 2018

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The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis

21 January 2018

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Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase

21 January 2018

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The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

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Assembly line polyketide synthases: mechanistic insights and unsolved problems

21 January 2018

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Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity.

21 January 2018

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Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.

21 January 2018

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Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story

21 January 2018

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Vancomycin assembly: nature's way.

21 January 2018

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Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

21 January 2018

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The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

21 January 2018

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Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase

21 January 2018

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Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B.

21 January 2018

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Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase

21 January 2018

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N-acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbF.

21 January 2018

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Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry

21 January 2018

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Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry

21 January 2018

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Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis

21 January 2018

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Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit

21 January 2018

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Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces

21 January 2018

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Utilization of alternate substrates by the first three modules of the epothilone synthetase assembly line

21 January 2018

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Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation

21 January 2018

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Portability of oxidase domains in nonribosomal peptide synthetase modules.

21 January 2018

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Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain

21 January 2018

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Peptidyl thiophenols as substrates for nonribosomal peptide cyclases

21 January 2018

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Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains

21 January 2018

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Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase

21 January 2018

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Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5.

21 January 2018

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The lyngbyatoxin biosynthetic assembly line: chain release by four-electron reduction of a dipeptidyl thioester to the corresponding alcohol

21 January 2018

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Cyclopiazonic acid biosynthesis in Aspergillus sp.: characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan

21 January 2018

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Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J.

21 January 2018

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Nature's inventory of halogenation catalysts: oxidative strategies predominate

21 January 2018

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Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

21 January 2018

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Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00035A

Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.

21 January 2018

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Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00035A

Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00035A

Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00035A

A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00035A

Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00035A

Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00035A

Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00035A

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00035A

A new antibiotic kills pathogens without detectable resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00035A

Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00035A

Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/C5NP00035A

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4 September 2017

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