(Q38601915)

English

Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells

scientific article published on July 2003

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells (English)

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

neoplastic invasiveness

1 reference

based on heuristic

inferred from title

Gregory E. Rice

5

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

author name string

N Ahmed

1

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

K Oliva

2

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Y Wang

3

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

M Quinn

4

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

language of work or name

0 references

publication date

1 July 2003

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

89

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

374-384

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-u-PAR-PAI-1 system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Role of urokinase receptor and caveolin in regulation of integrin signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Cancer invasion and tissue remodeling--cooperation of protease systems and cell types.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor-like domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Prevention of metastasis by inhibition of the urokinase receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Effects of urokinase receptor occupancy on plasmin generation and proteolysis of basement membrane by human tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Downregulation of the urokinase-type plasminogen activator receptor through inhibition of translation by antisense oligonucleotide suppresses invasion of human glioblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Urokinase-type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: dependence on extracellular matrix components.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Regulation of integrin function by the urokinase receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Overexpression of urokinase receptor in breast cancer cells results in increased tumor invasion, growth and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Molecular interactions in cell adhesion complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Urokinase receptor and colorectal cancer survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

Inhibition of colon cancer metastasis by a 3'- end antisense urokinase receptor mRNA in a nude mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

[Signaling pathways regulating the expression of proteases during tumor progression]

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

[Constitutive activation of the ERK-MAP kinase pathway in human tumors]

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct integrin alphavbeta6-ERK binding: implications for tumour growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Invasion of connective tissue by human carcinoma cell lines: requirement for urokinase, urokinase receptor, and interstitial collagenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

uPA/uPAR system is active in immature dendritic cells derived from CD14+CD34+ precursors and is down-regulated upon maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6601098

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

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release_7kryk24olbbpnl46j4aynde7ui

1 reference

https://api.fatcat.wiki/v0/release/7kryk24olbbpnl46j4aynde7ui

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

ResearchGate publication ID

0 references

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