(Q38629563)

English

Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

scientific article published on 18 July 2011

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scholarly article

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Europe PubMed Central

PMC publication ID

4 September 2017

Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90. (English)

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Clostridium difficile

0 references

Clostridium perfringens

object named as

Clostridium perfringens

1 reference

based on heuristic

inferred from title

8

object named as

Klaus Aktories

0 references

author name string

Eva Kaiser

1

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Claudia Kroll

2

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Katharina Ernst

3

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Carsten Schwan

4

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Michel Popoff

5

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Gunter Fischer

6

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Johannes Buchner

7

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Holger Barth

9

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

language of work or name

0 references

publication date

18 July 2011

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Europe PubMed Central

PMC publication ID

4 September 2017

Infection and Immunity

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Europe PubMed Central

PMC publication ID

4 September 2017

79

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

10

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

3913-3921

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Characterization of Clostridium difficile strains isolated from patients in Ontario, Canada, from 2004 to 2006

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Structure and mode of action of clostridial glucosylating toxins: the ABCD model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Anthrax toxin: receptor binding, internalization, pore formation, and translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

An epidemic, toxin gene-variant strain of Clostridium difficile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Thermodynamic characterization of the interaction of human cyclophilin 18 with cyclosporin A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Anthrax protective antigen: prepore-to-pore conversion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Steroid receptor interactions with heat shock protein and immunophilin chaperones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Clostridial enteric diseases of domestic animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Diphtheria toxin entry into cells is facilitated by low pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Purification and characterization of Clostridium perfringens iota toxin: dependence on two nonlinked proteins for biological activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Cellular uptake of the Clostridium perfringens binary iota-toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Clostridium perfringens iota toxin: binding studies and characterization of cell surface receptor by fluorescence-activated cytometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

6 September 2017

Binding component of Clostridium perfringens iota-toxin induces endocytosis in Vero cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

14 September 2017

Detergent-resistant membrane microdomains facilitate Ib oligomer formation and biological activity of Clostridium perfringens iota-toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

14 September 2017

The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

14 September 2017

The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

14 September 2017

Prolyl isomerase: enzymatic catalysis of slow protein-folding reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

14 September 2017

The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

25 September 2017

Clostridium perfringens iota toxin: characterization of the cell-associated iota b complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

25 September 2017

Lethal toxin of Bacillus anthracis causes apoptosis of macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

25 September 2017

Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

25 September 2017

Prolyl isomerases: role in protein folding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

25 September 2017

Purification and characterization of two components of botulinum C2 toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

25 September 2017

Conserved conformational changes in the ATPase cycle of human Hsp90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

23 June 2018

Interaction of Clostridium perfringens iota-toxin with lipid bilayer membranes. Demonstration of channel formation by the activated binding component Ib and channel block by the enzyme component Ia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

23 June 2018

Evidence that Arg-295, Glu-378, and Glu-380 are active-site residues of the ADP-ribosyltransferase activity of iota toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

23 June 2018

Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

23 June 2018

ADP-ribosylation of nonmuscle actin with component I of C2 toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

23 June 2018

Clostridium perfringens iota toxin: synergism between two proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

23 June 2018

Slow conformational changes in protein folding can be accelerated by enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

23 June 2018

Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

31 August 2018

Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

31 August 2018

Distribution of Clostridium difficile variant toxinotypes and strains with binary toxin genes among clinical isolates in an American hospital

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

31 August 2018

Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

31 August 2018

Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

31 August 2018

Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

31 August 2018

The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

31 August 2018

Differential requirement for the translocation of clostridial binary toxins: Iota toxin requires a membrane potential gradient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187244

3 December 2018

Clostridium difficile infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/21768281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Botulinum C2 toxin ADP-ribosylates actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21768281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP-ribosylation of skeletal muscle and non-muscle actin by Clostridium perfringens iota toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21768281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21768281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP-ribosylated actin caps the barbed ends of actin filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/21768281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological and functional comparison between Clostridium perfringens iota toxin, C. spiroforme toxin, and anthrax toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21768281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/IAI.05372-11

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

ResearchGate publication ID

0 references

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