(Q38631883)

4 September 2017

title

Control of microtubule organization and dynamics: two ends in the limelight (English)

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4 September 2017

1

Anna Akhmanova

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4 September 2017

Michel O Steinmetz

2

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publication date

12 November 2015

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Nature Reviews Molecular Cell Biology

4 September 2017

published in

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4 September 2017

volume

16

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4 September 2017

issue

12

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4 September 2017

page(s)

711-726

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https://scigraph.springernature.com/pub.10.1038/nrm4084

4 September 2017

exact match

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cites work

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Tracking the ends: a dynamic protein network controls the fate of microtubule tips

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XMAP215 is a processive microtubule polymerase

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Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase

21 January 2018

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Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo

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SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase

21 January 2018

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The microtubule lattice and plus-end association of Drosophila Mini spindles is spatially regulated to fine-tune microtubule dynamics.

21 January 2018

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Mammalian end binding proteins control persistent microtubule growth

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Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels

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EB1 accelerates two conformational transitions important for microtubule maturation and dynamics.

21 January 2018

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Kin I kinesins are microtubule-destabilizing enzymes

21 January 2018

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A mechanism for microtubule depolymerization by KinI kinesins

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Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases

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Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.

21 January 2018

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Move in for the kill: motile microtubule regulators

21 January 2018

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Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends.

21 January 2018

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GTPgammaS microtubules mimic the growing microtubule end structure recognized by end-binding proteins (EBs).

21 January 2018

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Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle

21 January 2018

1 reference

The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules

21 January 2018

1 reference

A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps.

21 January 2018

1 reference

CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.

21 January 2018

1 reference

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

21 January 2018

1 reference

Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A.

21 January 2018

1 reference

The kinesin-8 Kif18A dampens microtubule plus-end dynamics.

21 January 2018

1 reference

The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment

21 January 2018

1 reference

CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule

21 January 2018

1 reference

CLASPs are required for proper microtubule localization of end-binding proteins.

21 January 2018

1 reference

CLIPs and CLASPs and cellular dynamics

21 January 2018

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Cytoplasmic linker proteins promote microtubule rescue in vivo

21 January 2018

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Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor

21 January 2018

1 reference

Dynein tethers and stabilizes dynamic microtubule plus ends

21 January 2018

1 reference

Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters

21 January 2018

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Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos

21 January 2018

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The distribution of active force generators controls mitotic spindle position

21 January 2018

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Mechanisms of spindle positioning

21 January 2018

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MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis

21 January 2018

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Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1)

21 January 2018

1 reference

Molecular insights into mammalian end-binding protein heterodimerization

21 January 2018

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Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end.

21 January 2018

1 reference

Microtubule +TIP protein EB1 binds to GTP and undergoes dissociation from dimer to monomer on binding GTP.

21 January 2018

1 reference

Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1

21 January 2018

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Superresolution imaging reveals structural features of EB1 in microtubule plus-end tracking.

21 January 2018

1 reference

Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice

21 January 2018

1 reference

A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules.

21 January 2018

1 reference

Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis

21 January 2018

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Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p

21 January 2018

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EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.

21 January 2018

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Ubiquitin-dependent proteolysis of the microtubule end-binding protein 1, EB1, is controlled by the COP9 signalosome: possible consequences for microtubule filament stability.

21 January 2018

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The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

21 January 2018

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Reconstitution of a microtubule plus-end tracking system in vitro

21 January 2018

1 reference

Estimating the microtubule GTP cap size in vivo.

21 January 2018

1 reference

Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends

21 January 2018

1 reference

EB1 recognizes the nucleotide state of tubulin in the microtubule lattice

21 January 2018

1 reference

EBs Recognize a Nucleotide-Dependent Structural Cap at Growing Microtubule Ends

21 January 2018

1 reference

Doublecortin recognizes the longitudinal curvature of the microtubule end and lattice.

21 January 2018

1 reference

Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.

21 January 2018

1 reference

Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding

21 January 2018

1 reference

The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array

21 January 2018

1 reference

A TOG: -tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase

21 January 2018

1 reference

A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

21 January 2018

1 reference

XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region

21 January 2018

1 reference

Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells

21 January 2018

1 reference

Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips

21 January 2018

1 reference

A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.

21 January 2018

1 reference

Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation

21 January 2018

1 reference

Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8.

21 January 2018

1 reference

Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK.

21 January 2018

1 reference

The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch.

21 January 2018

1 reference

Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association

21 January 2018

1 reference

The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends

21 January 2018

1 reference

Template-free 13-protofilament microtubule–MAP assembly visualized at 8 Å resolution

21 January 2018

1 reference

The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion

21 January 2018

1 reference

The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex

21 January 2018

1 reference

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

21 January 2018

1 reference

Mechanisms of force generation by end-on kinetochore-microtubule attachments.

21 January 2018

1 reference

Structure-function relationship of CAP-Gly domains

21 January 2018

1 reference

Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition

21 January 2018

1 reference

Key interaction modes of dynamic +TIP networks.

21 January 2018

1 reference

An EB1-binding motif acts as a microtubule tip localization signal

21 January 2018

1 reference

+TIPs: SxIPping along microtubule ends

21 January 2018

1 reference

A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins.

21 January 2018

1 reference

A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset.

21 January 2018

1 reference

Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).

21 January 2018

1 reference

Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin

21 January 2018

1 reference

Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein

21 January 2018

1 reference

Reconstitution of dynein transport to the microtubule plus end by kinesin

21 January 2018

1 reference

A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases

21 January 2018

1 reference

Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network.

21 January 2018

1 reference

Phase transitions in the assembly of multivalent signalling proteins

21 January 2018

1 reference

ACF7: an essential integrator of microtubule dynamics

21 January 2018

1 reference

21 January 2018

1 reference

Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins).

21 January 2018

1 reference

Actin-microtubule coordination at growing microtubule ends

21 January 2018

1 reference

Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex

21 January 2018

1 reference

Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites.

21 January 2018

1 reference

Mechanical and geometrical constraints control kinesin-based microtubule guidance.

21 January 2018

1 reference

An EB1-kinesin complex is sufficient to steer microtubule growth in vitro

21 January 2018

1 reference

The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning

21 January 2018

1 reference

The human kinesin-14 HSET tracks the tips of growing microtubules in vitro

21 January 2018

1 reference

Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins

21 January 2018

1 reference

Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast.

21 January 2018

1 reference

A minus-end-directed kinesin with plus-end tracking protein activity is involved in spindle morphogenesis

21 January 2018

1 reference

Minus-end-directed Kinesin-14 motors align antiparallel microtubules to control metaphase spindle length

21 January 2018

1 reference

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

21 January 2018

1 reference

Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension.

21 January 2018

1 reference

Cortical control of microtubule stability and polarization

21 January 2018

1 reference

Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration

21 January 2018

1 reference

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

21 January 2018

1 reference

CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles

21 January 2018

1 reference

Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport

21 January 2018

1 reference

Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner

21 January 2018

1 reference

Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension

21 January 2018

1 reference

STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER.

21 January 2018

1 reference

Microtubule nucleation by γ-tubulin complexes

21 January 2018

1 reference

Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2.

21 January 2018

1 reference

Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function

21 January 2018

1 reference

Desmoplakin: an unexpected regulator of microtubule organization in the epidermis

21 January 2018

1 reference

Assembly of centrosomal proteins and microtubule organization depends on PCM-1

21 January 2018

1 reference

Microtubule-associated proteins control the kinetics of microtubule nucleation

21 January 2018

1 reference

Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin

21 January 2018

1 reference

Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition

21 January 2018

1 reference

Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts

21 January 2018

1 reference

Patronin regulates the microtubule network by protecting microtubule minus ends.

21 January 2018

1 reference

Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules

21 January 2018

1 reference

Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development

21 January 2018

1 reference

The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites

21 January 2018

1 reference

The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans

21 January 2018

1 reference

21 January 2018

The minus end in sight

1 reference

Patronin mediates a switch from kinesin-13-dependent poleward flux to anaphase B spindle elongation

21 January 2018

1 reference

Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration

21 January 2018

1 reference

Cell cycle regulation of microtubule interactomes: multi-layered regulation is critical for the interphase/mitosis transition

21 January 2018

1 reference

K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly.

21 January 2018

1 reference

Microtubule organization and microtubule-associated proteins in plant cells

21 January 2018

1 reference

Microtubule-binding agents: a dynamic field of cancer therapeutics

21 January 2018

1 reference

Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death.

21 January 2018

1 reference

End-binding proteins sensitize microtubules to the action of microtubule-targeting agents

21 January 2018

1 reference

End-binding 1 protein overexpression correlates with glioblastoma progression and sensitizes to Vinca-alkaloids in vitro and in vivo

21 January 2018

1 reference

Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics.

21 January 2018

1 reference

Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration

21 January 2018

1 reference

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

21 January 2018

1 reference

Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants.

21 January 2018

1 reference

Overexpression, purification, and functional analysis of recombinant human tubulin dimer

21 January 2018

1 reference

Micropattern-guided assembly of overlapping pairs of dynamic microtubules.

21 January 2018

1 reference

Molecular mechanism of action of microtubule-stabilizing anticancer agents

21 January 2018

1 reference

Structural basis of microtubule stabilization by laulimalide and peloruside A

21 January 2018

1 reference

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

21 January 2018

1 reference

Mechanism of inhibition of microtubule polymerization by colchicine: inhibitory potencies of unliganded colchicine and tubulin-colchicine complexes

21 January 2018

1 reference

Structural basis for the regulation of tubulin by vinblastine

21 January 2018

1 reference

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

21 January 2018

1 reference

The determinants that govern microtubule assembly from the atomic structure of GTP-tubulin

21 January 2018

1 reference

Structure of the alpha beta tubulin dimer by electron crystallography

21 January 2018

1 reference

Tubulin and FtsZ form a distinct family of GTPases

21 January 2018

1 reference

Structural insights into the EB1-APC interaction

21 January 2018

1 reference

Capturing protein tails by CAP-Gly domains

21 January 2018

1 reference

Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization

21 January 2018

1 reference

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility

21 January 2018

1 reference

Depolymerizing kinesins Kip3 and MCAK shape cellular microtubule architecture by differential control of catastrophe.

21 January 2018

1 reference

Kinesin-8 Motors Act Cooperatively to Mediate Length-Dependent Microtubule Depolymerization

31 March 2020

1 reference

Asymmetric loading of Kar9 onto spindle poles and microtubules ensures proper spindle alignment

31 March 2020

1 reference

A new function for the gamma-tubulin ring complex as a microtubule minus-end cap

31 March 2020

1 reference

PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons

31 March 2020

1 reference

+TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules

31 March 2020

1 reference

Purification of tubulin from the fission yeast Schizosaccharomyces pombe

31 March 2020

1 reference

Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: the role of ninein

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26562752

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM4084

1 reference

Dimensions Publication ID

4 September 2017

1040767126

0 references

1 reference