(Q38652194)

5 September 2017

title

Colorectal Cancer Subtypes: Developmental Origin and Microenvironmental Regulation (English)

1 reference

5 September 2017

1 reference

1 reference

Evelyn Fessler

1

1 reference

5 September 2017

Jan Paul Medema

series ordinal

2

1 reference

5 September 2017

language of work or name

1 reference

3 September 2016

1 reference

5 September 2017

1 reference

5 September 2017

volume

2

1 reference

5 September 2017

issue

9

1 reference

5 September 2017

page(s)

505-518

1 reference

Systematic review of microsatellite instability and colorectal cancer prognosis

5 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Poor Survival Associated with theBRAFV600E Mutation in Microsatellite-Stable Colon Cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Identification of a poor-prognosis BRAF-mutant-like population of patients with colon cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Dissecting cancer heterogeneity--an unsupervised classification approach

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Colon cancer molecular subtypes identified by expression profiling and associated to stroma, mucinous type and different clinical behavior.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Comprehensive molecular characterization of human colon and rectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

The consensus molecular subtypes of colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A genetic model for colorectal tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A Big Bang model of human colorectal tumor growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Comprehensive molecular characterization of gastric adenocarcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Systematic identification of genomic markers of drug sensitivity in cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Prospective derivation of a living organoid biobank of colorectal cancer patients.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Patient-derived tumour xenografts as models for oncology drug development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Cells of origin in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Crypt stem cells as the cells-of-origin of intestinal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Stem cell dynamics in homeostasis and cancer of the intestine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Bcl-2 is a critical mediator of intestinal transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Cell of origin strongly influences genetic selection in a mouse model of T-ALL

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Tissue-specific designs of stem cell hierarchies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Interconversion between intestinal stem cell populations in distinct niches

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Is right-sided colon cancer different to left-sided colorectal cancer? - a systematic review.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Colorectal cancer: a tale of two sides or a continuum?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Molecular genetics of colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

The evolution of cancer of the colon and rectum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Serrated neoplasia-role in colorectal carcinogenesis and clinical implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Role of the serrated pathway in colorectal cancer pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Update on the serrated pathway to colorectal carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Classification of colorectal cancer based on correlation of clinical, morphological and molecular features

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Association between molecular subtypes of colorectal cancer and patient survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Multiplex genome engineering using CRISPR/Cas systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

RNA-guided human genome engineering via Cas9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Sequential cancer mutations in cultured human intestinal stem cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Tumors as organs: complex tissues that interface with the entire organism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Colitis-associated cancer: the role of T cells in tumor development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Inflammatory bowel disease and colon cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

7 January 2021

Fibroblasts in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Stromal contribution to the colorectal cancer transcriptome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Role of stromal myofibroblasts in invasive breast cancer: stromal expression of alpha-smooth muscle actin correlates with worse clinical outcome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

alpha-Smooth Muscle Actin Expressing Stroma Promotes an Aggressive Tumor Biology in Pancreatic Ductal Adenocarcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Stromal gene expression predicts clinical outcome in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Influence of tumour micro-environment heterogeneity on therapeutic response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

7 January 2021

Mouse models of cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

New drugs for breast cancer subtypes: targeting driver pathways to overcome resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Cancer heterogeneity--a multifaceted view

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

The genomic landscape of response to EGFR blockade in colorectal cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

Cancer genes and the pathways they control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2016.07.008

10.1016/J.TRECAN.2016.07.008

7 January 2021

Identifiers

DOI

1 reference

5 September 2017

1 reference