(Q36930106)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

The genomic landscape of response to EGFR blockade in colorectal cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Francesca Cottino

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Giorgia Migliardi

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Eugenia R Zanella

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Alfredo Mellano

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Silvia Marsoni

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Andrea Sartore-Bianchi

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Salvatore Siena

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Luis Alberto Diaz Jr

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Victor Velculescu

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1

Andrea Bertotti

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

10

Collin Tokheim

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

30

Robert Scharpf

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

7

Mark Sausen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

8

Jillian Phallen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

4

Vilmos Adleff

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

5

Valsamo Anagnostou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

9

Carolyn A Hruban

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

27

Andrea Cassingena

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

34

Livio Trusolino

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

13

Karli Lytle

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

2

Eniko Papp

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

11

Noushin Niknafs

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

12

Monica Nesselbush

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

29

Rachel Karchin

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

author name string

Barbara Lupo

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Dario Ribero

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Nadia Russolillo

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Andrea Muratore

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Gianluca Paraluppi

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Mauro Salizzoni

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Michael Kragh

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Johan Lantto

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Qing Kay Li

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Siân Jones

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

language of work or name

English

0 references

publication date

30 September 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

volume

526

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

issue

7572

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

page(s)

263-267

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

25 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4878148/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nature14969

0 references

cites work

Personalized genomic analyses for cancer mutation discovery and interpretation

1 reference

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Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

29 September 2017

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Detection of circulating tumor DNA in early- and late-stage human malignancies

29 September 2017

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Phase II open-label study to assess efficacy and safety of lenalidomide in combination with cetuximab in KRAS-mutant metastatic colorectal cancer

29 September 2017

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Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

29 September 2017

1 reference

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Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871).

29 September 2017

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Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Functional dissection of the epidermal growth factor receptor epitopes targeted by panitumumab and cetuximab.

29 September 2017

1 reference

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LAS: a software platform to support oncological data management

29 September 2017

1 reference

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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

29 September 2017

1 reference

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A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

29 September 2017

1 reference

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Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

29 September 2017

1 reference

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Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor

29 September 2017

1 reference

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Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Fibroblast growth factors and their receptors in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

EGFR gene copy number assessment from areas with highest EGFR expression predicts response to anti-EGFR therapy in colorectal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Diverse somatic mutation patterns and pathway alterations in human cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers

29 September 2017

1 reference

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Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma

29 September 2017

1 reference

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Comparative lesion sequencing provides insights into tumor evolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

The consensus coding sequences of human breast and colorectal cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

PDGFRA activating mutations in gastrointestinal stromal tumors.

29 September 2017

1 reference

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A general method applicable to the search for similarities in the amino acid sequence of two proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Colorectal cancer: mutations in a signalling pathway

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Somatic mutation of EGFR catalytic domain and treatment with gefitinib in colorectal cancer

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Somatic mutations of EGFR in colorectal cancers and glioblastomas

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

Switching on kinases: oncogenic activation of BRAF and the PDGFR family

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878148

HER2 activating mutations are targets for colorectal cancer treatment

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE14969

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE14969

21 January 2018

Identifiers

DOI

10.1038/NATURE14969

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26416732%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference