(Q45041454)

8 December 2017

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title

Switching on kinases: oncogenic activation of BRAF and the PDGFR family (English)

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8 December 2017

Nick J Dibb

1

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8 December 2017

Stephen M Dilworth

series ordinal

2

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8 December 2017

Clifford D Mol

series ordinal

3

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8 December 2017

language of work or name

English

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publication date

1 September 2004

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8 December 2017

Nature Reviews Cancer

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8 December 2017

4

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8 December 2017

718-727

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8 December 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrc1434

8 December 2017

0 references

cites work

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21 January 2018

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Transcriptional regulation by the MAP kinase signaling cascades

21 January 2018

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High frequency of BRAF mutations in nevi

21 January 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

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Proteomic approaches to the analysis of early events in colony-stimulating factor-1 signal transduction

21 January 2018

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The role of FLT3 in haematopoietic malignancies

21 January 2018

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CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract

21 January 2018

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Class III receptor tyrosine kinases: role in leukaemogenesis

21 January 2018

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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

21 January 2018

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KIT mutations are common in testicular seminomas

21 January 2018

1 reference

Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

21 January 2018

1 reference

PDGFRA activating mutations in gastrointestinal stromal tumors.

21 January 2018

1 reference

Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

The protein kinase complement of the human genome

21 January 2018

1 reference

The conformational plasticity of protein kinases

21 January 2018

1 reference

Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

1 reference

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

21 January 2018

1 reference

Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

21 January 2018

1 reference

Structure of a c-kit product complex reveals the basis for kinase transactivation

21 January 2018

1 reference

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

21 January 2018

1 reference

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

21 January 2018

1 reference

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

21 January 2018

1 reference

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

21 January 2018

1 reference

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

21 January 2018

1 reference

The structure of mitogen-activated protein kinase p38 at 2.1-A resolution

21 January 2018

1 reference

The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation

21 January 2018

1 reference

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

21 January 2018

1 reference

Structural aspects of protein kinase control-role of conformational flexibility

21 January 2018

1 reference

Crystal structure of cyclin-dependent kinase 2

21 January 2018

1 reference

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

21 January 2018

1 reference

Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A

21 January 2018

1 reference

To cycle or not to cycle: a critical decision in cancer.

21 January 2018

1 reference

Structural basis of cyclin-dependent kinase activation by phosphorylation

21 January 2018

1 reference

Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

21 January 2018

1 reference

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

1 reference

A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571.

21 January 2018

1 reference

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

21 January 2018

1 reference

Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

21 January 2018

1 reference

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

21 January 2018

1 reference

Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor

21 January 2018

1 reference

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

21 January 2018

1 reference

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

21 January 2018

1 reference

Cell specific transformation by c-fms activating loop mutations is attributable to constitutive receptor degradation

21 January 2018

1 reference

The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

21 January 2018

1 reference

Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy

21 January 2018

1 reference

Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms

21 January 2018

1 reference

Role of aspartic acid 814 in the function and expression of c-kit receptor tyrosine kinase

21 January 2018

1 reference

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

1 reference

Management of malignant gastrointestinal stromal tumours

21 January 2018

1 reference

Oncogenic tyrosine kinases and the DNA-damage response

21 January 2018

1 reference

Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta

21 January 2018

1 reference

PDGF receptors as cancer drug targets

21 January 2018

1 reference

Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

21 January 2018

1 reference

Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias.

21 January 2018

1 reference

Variation on an Src-like theme

21 January 2018

1 reference

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

21 January 2018

1 reference

Bypassing a Kinase Activity with an ATP-Competitive Drug

21 January 2018

1 reference

Protein tyrosine kinases: autoregulation and small-molecule inhibition

21 January 2018

1 reference

Structural basis for the autoinhibition of c-Abl tyrosine kinase

21 January 2018

1 reference

Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia

21 January 2018

1 reference

Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy

21 January 2018

1 reference

SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model

21 January 2018

1 reference

Mutational analysis of the tyrosine kinome in colorectal cancers

21 January 2018

1 reference

RTK mutations and human syndromeswhen good receptors turn bad.

21 January 2018

1 reference

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

1 reference

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 January 2018

1 reference

The discovery of the alpha-helix and beta-sheet, the principal structural features of proteins

21 January 2018

1 reference

Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region.

21 January 2018

1 reference

Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas

21 January 2018

1 reference

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

21 January 2018

1 reference

Mechanism of action and in vivo role of platelet-derived growth factor

31 March 2020

1 reference

Signal transduction by receptors with tyrosine kinase activity

31 March 2020

1 reference

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

31 March 2020

1 reference

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

31 March 2020

1 reference

Steel factor and c-kit protooncogene: genetic lessons in signal transduction

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

C-kit gene mutation in human gastrointestinal stromal tumors

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1434

1 reference

Dimensions Publication ID

8 December 2017

1022431788

0 references

Fatcat ID

release_lu5upeu5cnarffjh3fip7txxqa

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lu5upeu5cnarffjh3fip7txxqa

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference