(Q38669233)

5 September 2017

title

Epigenetic targets in cancer and aging: dietary and therapeutic interventions (English)

1 reference

5 September 2017

Sajid Khan

1

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5 September 2017

Samriddhi Shukla

series ordinal

2

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5 September 2017

Sonam Sinha

series ordinal

3

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5 September 2017

Syed Musthapa Meeran

series ordinal

4

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5 September 2017

language of work or name

English

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publication date

15 December 2015

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Expert Opinion on Therapeutic Targets

5 September 2017

published in

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5 September 2017

volume

20

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5 September 2017

issue

6

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5 September 2017

page(s)

689-703

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Ageing and cancer as diseases of epigenesis

5 September 2017

cites work

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Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication

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Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model

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Breast cancer epigenetics: from DNA methylation to microRNAs

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Effects of DNA methylation on DNA-binding proteins and gene expression.

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Methyl CpG-binding proteins and transcriptional repression

21 January 2018

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Methyl-CpG-binding proteins. Targeting specific gene repression.

21 January 2018

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Epigenetic targets of bioactive dietary components for cancer prevention and therapy

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Cancer epigenetics: from mechanism to therapy

21 January 2018

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Dietary modulation of the multistage, multimechanisms of human carcinogenesis: effects on initiated stem cells and cell-cell communication

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A decade of exploring the cancer epigenome - biological and translational implications

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DNA methylation and human disease

21 January 2018

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Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

21 January 2018

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DNA methylation and cancer development: molecular mechanism

21 January 2018

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The epigenetics of breast cancer

21 January 2018

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Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

21 January 2018

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DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

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Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice

21 January 2018

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Role of adipokines and cytokines in obesity-associated breast cancer: therapeutic targets

21 January 2018

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High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia

21 January 2018

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Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors

21 January 2018

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Fragile histidine triad (FHIT) gene abnormalities in lung cancer.

21 January 2018

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HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Correlation of telomere length shortening with promoter methylation profile of p16/Rb and p53/p21 pathways in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

DNA methylation of RASSF1A, HIN‐1, RAR‐β, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Glypican-3 expression is silenced in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

DNA methylation and breast carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Differential hypermethylation of SOCS genes in ovarian and breast carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

The MYST family of histone acetyltransferases and their intimate links to cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Prospects: histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Towards the human cancer epigenome: a first draft of histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Global histone modification patterns predict risk of prostate cancer recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

21 January 2018

Epigenetics in cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

21 January 2018

The epigenetics pipeline

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetics of cancer stem cells: Pathways and therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Stem cells in toxicology: fundamental biology and practical considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

DNA methyltransferase 1 is essential for initiation of the colon cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetic alteration and microRNA dysregulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Downregulation of miR-342 is associated with tamoxifen resistant breast tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Cross-talk between aging and cancer: the epigenetic language

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Genetics and epigenetics of aging and longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetic differences arise during the lifetime of monozygotic twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Differential gene expression and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Role of diet and nutrition on the alteration of the quality and quantity of stem cells in human aging and the diseases of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Dietary epigenetics in cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Widespread and tissue specific age-related DNA methylation changes in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetics and aging: the targets and the marks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Histone methylation makes its mark on longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Mammalian sirtuins: biological insights and disease relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Regulation of SIRT1 protein levels by nutrient availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

21 January 2018

The hallmarks of aging

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

SIRT6 protects against pathological damage caused by diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

DNA methyltransferases control telomere length and telomere recombination in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Genetic and epigenetic modulation of telomerase activity in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

MicroRNA and senescence: the senectome, integration and distributed control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

MicroRNA-34a regulates cardiac ageing and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Circulating inflamma-miRs in aging and age-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Gap junctions as targets for cancer chemoprevention and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Toward a unified theory of caloric restriction and longevity regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Sirt1: a metabolic master switch that modulates lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Development of curcumin as an epigenetic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

A two-stage, single-arm, phase II study of EGCG-enriched green tea drink as a maintenance therapy in women with advanced stage ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Trials with 'epigenetic' drugs: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: a randomized, double-blind placebo-controlled cross-over 4g study and an open-label 8g extension study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Curcumin-induced histone hypoacetylation: the role of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Mechanism of human SIRT1 activation by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

SIRT1 stimulation by polyphenols is affected by their stability and metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Effects of soy isoflavones on mammographic density and breast parenchyma in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Regulation of SIRT1 in cellular functions: role of polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

High absorption but very low bioavailability of oral resveratrol in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Altered histone acetylation is associated with age-dependent memory impairment in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Resveratrol: challenges in translation to the clinic--a critical discussion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1132702

10.1517/14728222.2016.1132702

21 January 2018

Identifiers

DOI

1 reference

5 September 2017

1 reference