(Q38673428)

5 September 2017

title

The many faces of Mac-1 in autoimmune disease (English)

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5 September 2017

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Florencia Rosetti

1

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5 September 2017

Tanya N Mayadas

series ordinal

2

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5 September 2017

publication date

1 January 2016

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5 September 2017

published in

Immunological Reviews

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5 September 2017

volume

269

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5 September 2017

issue

1

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5 September 2017

page(s)

175-193

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Therapeutics to block autoantibody initiation and propagation in systemic lupus erythematosus and rheumatoid arthritis.

5 September 2017

cites work

1 reference

Mapping lupus susceptibility genes in the NZM2410 mouse model

21 January 2018

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Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex-mediated acute lupus glomerulonephritis

21 January 2018

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Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.

21 January 2018

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Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency

21 January 2018

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Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease

21 January 2018

1 reference

Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance.

21 January 2018

1 reference

The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes

21 January 2018

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A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis

21 January 2018

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Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.

21 January 2018

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Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

21 January 2018

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CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages

21 January 2018

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Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus.

21 January 2018

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Neutrophils: game changers in glomerulonephritis?

21 January 2018

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Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

21 January 2018

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Microarray analysis of glomerular gene expression in murine lupus nephritis

21 January 2018

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Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

21 January 2018

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Low density neutrophils in patients with systemic lupus erythematosus, rheumatoid arthritis, and acute rheumatic fever

21 January 2018

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A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs

21 January 2018

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Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response

21 January 2018

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A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1.

21 January 2018

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The multifaceted functions of neutrophils

21 January 2018

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Integrin Regulation during Leukocyte Recruitment

21 January 2018

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Reconstruction of integrin activation

21 January 2018

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The tail of integrin activation

21 January 2018

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Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction.

21 January 2018

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P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils

21 January 2018

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Catch-bond mechanism of force-enhanced adhesion: counterintuitive, elusive, but ... widespread?

21 January 2018

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Forcing switch from short- to intermediate- and long-lived states of the alphaA domain generates LFA-1/ICAM-1 catch bonds

21 January 2018

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Neutrophil beta2 integrins: moderators of life or death decisions

21 January 2018

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Integrin avidity regulation: are changes in affinity and conformation underemphasized?

21 January 2018

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The tail of integrins, talin, and kindlins

21 January 2018

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Integrins: bidirectional, allosteric signaling machines

21 January 2018

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Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

21 January 2018

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Outside-in signal transmission by conformational changes in integrin Mac-1

21 January 2018

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

21 January 2018

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Folding and function of I domain-deleted Mac-1 and lymphocyte function-associated antigen-1.

21 January 2018

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Lectin site ligation of CR3 induces conformational changes and signaling

21 January 2018

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Binding of Soluble Yeast β-Glucan to Human Neutrophils and Monocytes is Complement-Dependent

21 January 2018

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Differential regulation of oxidative burst by distinct β-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells.

21 January 2018

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Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models

21 January 2018

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Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

21 January 2018

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21 January 2018

The kindlins at a glance

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The insider's guide to leukocyte integrin signalling and function

21 January 2018

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Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils

21 January 2018

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Ligand recognition specificity of leukocyte integrin αMβ2 (Mac-1, CD11b/CD18) and its functional consequences

21 January 2018

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Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury

21 January 2018

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Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade

21 January 2018

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Rapid leukocyte migration by integrin-independent flowing and squeezing

21 January 2018

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CR3: a general purpose adhesion-recognition receptor essential for innate immunity

21 January 2018

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The Mac-1 and p150,95 beta 2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesion

21 January 2018

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Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2

21 January 2018

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HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.

21 January 2018

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Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein

21 January 2018

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CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses

21 January 2018

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The role of integrin alpha D beta2 (CD11d/CD18) in monocyte/macrophage migration

21 January 2018

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Integrin αDβ2 (CD11d/CD18) is expressed by human circulating and tissue myeloid leukocytes and mediates inflammatory signaling

21 January 2018

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Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.

21 January 2018

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21 January 2018

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Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B).

21 January 2018

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The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria

21 January 2018

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The PI-linked receptor FcRIII is released on stimulation of neutrophils

21 January 2018

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Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases

21 January 2018

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Ebola virus secretory glycoprotein (sGP) diminishes Fc gamma RIIIB-to-CR3 proximity on neutrophils

21 January 2018

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Cross-talk between Fc receptors and integrins.

21 January 2018

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Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis

21 January 2018

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Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation

21 January 2018

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Mac-1 promotes FcgammaRIIA-dependent cell spreading and migration on immune complexes

21 January 2018

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The cytoplasmic domain of FcgammaRIIA (CD32) participates in phagolysosome formation

21 January 2018

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Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation.

21 January 2018

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Immune complex-stimulated neutrophil LTB4 production is dependent on beta 2 integrins

21 January 2018

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Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice

21 January 2018

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Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury

21 January 2018

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Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo.

21 January 2018

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Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRIIIB and Mac-1.

21 January 2018

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Beneficial suicide: why neutrophils die to make NETs

21 January 2018

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CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation

21 January 2018

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Convergence of Fc gamma receptor IIA and Fc gamma receptor IIIB signaling pathways in human neutrophils

21 January 2018

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Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function

21 January 2018

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Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR).

21 January 2018

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β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier

21 January 2018

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Anti-GBM nephritis in the mouse: role of granulocytes in the heterologous phase

21 January 2018

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The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition

21 January 2018

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Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid

21 January 2018

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Arthritis critically dependent on innate immune system players

21 January 2018

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The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

21 January 2018

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The β-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance

21 January 2018

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The role of macrophage 1 antigen in polymicrobial sepsis.

21 January 2018

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The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae

21 January 2018

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Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo

21 January 2018

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Complement-dependent clearance of apoptotic cells by human macrophages

21 January 2018

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Links between complement deficiency and apoptosis

21 January 2018

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A small CD11b(+) human B1 cell subpopulation stimulates T cells and is expanded in lupus

21 January 2018

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Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity

21 January 2018

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CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation

21 January 2018

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Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration

21 January 2018

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A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.

21 January 2018

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Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

21 January 2018

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A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways

21 January 2018

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Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins

21 January 2018

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Inhibitory ITAMs as novel regulators of immunity.

21 January 2018

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How ITAMs inhibit signaling

21 January 2018

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Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

21 January 2018

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A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

21 January 2018

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Systemic lupus erythematosus.

21 January 2018

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Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).

21 January 2018

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Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases

21 January 2018

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Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts

21 January 2018

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A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis

21 January 2018

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Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells

21 January 2018

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Human alloantibody anti-Mart interferes with Mac-1-dependent leukocyte adhesion

21 January 2018

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Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils

21 January 2018

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Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM

21 January 2018

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An internal ligand-bound, metastable state of a leukocyte integrin, α X β 2

21 January 2018

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Promotion of leukocyte adhesion by a novel interaction between vitronectin and the beta2 integrin Mac-1 (alphaMbeta2, CD11b/CD18).

21 January 2018

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Loss of CD11b exacerbates murine complement-mediated tubulointerstitial nephritis.

21 January 2018

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A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

21 January 2018

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Immunology: Dendritic Cells Pull the T Cell’s Strings

21 January 2018

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The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features

21 January 2018

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Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12373

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5 September 2017

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