(Q38683207)

5 September 2017

title

9 Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt): A key enzyme in CaaX processing (English)

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5 September 2017

Jessica L Anderson

1

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5 September 2017

Christine A Hrycyna

series ordinal

2

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5 September 2017

publication date

1 January 2006

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5 September 2017

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5 September 2017

volume

24

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5 September 2017

page(s)

245-272

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Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

5 September 2017

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Protein prenylation: molecular mechanisms and functional consequences

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Modification of eukaryotic signaling proteins by C-terminal methylation reactions

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7 January 2021

Protein prenyltransferases

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7 January 2021

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

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7 January 2021

RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

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7 January 2021

Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export

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7 January 2021

Post-translational processing of RhoA. Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of Rhoa

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7 January 2021

Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone

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Protein prenylation: from discovery to prospects for cancer treatment.

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7 January 2021

Structure, mechanism and function of prenyltransferases

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7 January 2021

Protein farnesyltransferase

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7 January 2021

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

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7 January 2021

The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor

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7 January 2021

Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae

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7 January 2021

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

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7 January 2021

The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membrane

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7 January 2021

Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt)

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7 January 2021

Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes

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7 January 2021

Peptidal Sex Hormones Inducing Conjugation Tube Formation in Compatible Mating-Type Cells of Tremella mesenterica

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7 January 2021

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7 January 2021

The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope

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7 January 2021

All ras proteins are polyisoprenylated but only some are palmitoylated

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7 January 2021

Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans.

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7 January 2021

The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein

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7 January 2021

Activation and solubilization of the retinal cGMP-specific phosphodiesterase by limited proteolysis. Role of the C-terminal domain of the beta-subunit

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7 January 2021

Farnesylated γ-subunit of photoreceptor G protein indispensable for GTP-binding

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7 January 2021

The gamma subunit of brain G-proteins is methyl esterified at a C-terminal cysteine

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7 January 2021

Yeast STE14 methyltransferase, expressed as TrpE-STE14 fusion protein in Escherichia coli, for in vitro carboxylmethylation of prenylated polypeptides

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7 January 2021

Biogenesis of the Saccharomyces cerevisiae mating pheromone a-factor

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7 January 2021

Biogenesis of yeast a-factor involves prenylation, methylation and a novel export mechanism

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7 January 2021

Purification, functional reconstitution, and characterization of the Saccharomyces cerevisiae isoprenylcysteine carboxylmethyltransferase Ste14p

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7 January 2021

Protein carboxyl methylation in Saccharomyces cerevisiae: evidence for STE14-dependent and STE14-independent pathways

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7 January 2021

Isolation and DNA sequence of the STE14 gene encoding farnesyl cysteine: carboxyl methyltransferase

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7 January 2021

Topological and mutational analysis of Saccharomyces cerevisiae Ste14p, founding member of the isoprenylcysteine carboxyl methyltransferase family

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7 January 2021

A turn propensity scale for transmembrane helices

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7 January 2021

Turns in transmembrane helices: determination of the minimal length of a “helical hairpin” and derivation of a fine-grained turn propensity scale 1 1Edited by F. E. Cohen

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7 January 2021

The GxxxG motif: a framework for transmembrane helix-helix association

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7 January 2021

Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions

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7 January 2021

Trypanosoma brucei prenylated-protein carboxyl methyltransferase prefers farnesylated substrates

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7 January 2021

The carboxyl methyltransferase modifying G proteins is a metalloenzyme

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7 January 2021

Inhibition of membrane-associated methyltransferases by a cholesterol-based metal chelator

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7 January 2021

Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis

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7 January 2021

Identification and functional expression in yeast of a prenylcysteine alpha-carboxyl methyltransferase gene from Arabidopsis thaliana

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7 January 2021

Prenylcysteine alpha-carboxyl methyltransferase expression and function in Arabidopsis thaliana

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7 January 2021

Prenylcysteine alpha-carboxyl methyltransferase in suspension-cultured tobacco cells

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7 January 2021

Partial purification of protein farnesyl cysteine carboxyl methyltransferase from bovine brain

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7 January 2021

Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

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7 January 2021

A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues

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7 January 2021

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

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7 January 2021

Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates

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7 January 2021

Identification of an isoprenylated cysteine methyl ester hydrolase activity in bovine rod outer segment membranes

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7 January 2021

Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity

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7 January 2021

Heteroatom requirements for substrate recognition by GTP-binding protein methyltransferase

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7 January 2021

Identification of prenylcysteine carboxymethyltransferase in bovine adrenal chromaffin cells

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7 January 2021

Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice

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7 January 2021

Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis

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7 January 2021

Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation

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7 January 2021

Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase.

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7 January 2021

Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils

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7 January 2021

Characterization of prenylcysteine methyltransferase in insulin-secreting cells

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7 January 2021

Modulation of tumor necrosis factor-alpha-mediated cytotoxicity by changes of the cellular methylation state: mechanism and in vivo relevance.

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7 January 2021

Farnesylcysteine analogs to probe role of prenylated protein methyltransferase

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7 January 2021

Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion

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7 January 2021

Isoprenylcysteine-O-carboxyl methyltransferase regulates aldosterone-sensitive Na(+) reabsorption

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7 January 2021

Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases

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7 January 2021

p21ras farnesyltransferase: purification and properties of the enzyme

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7 January 2021

Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit

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7 January 2021

The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures

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7 January 2021

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

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7 January 2021

Inhibition of Ras function in vitro and in vivo using inhibitors of farnesyl-protein transferase

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7 January 2021

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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7 January 2021

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

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7 January 2021

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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7 January 2021

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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7 January 2021

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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7 January 2021

Post-prenylation-processing enzymes as new targets in oncogenesis

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7 January 2021

Ras signalling on the endoplasmic reticulum and the Golgi

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7 January 2021

The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules

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7 January 2021

The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors

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7 January 2021

Fatty acylation is important but not essential for Saccharomyces cerevisiae RAS function

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7 January 2021

Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae

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7 January 2021

10.1016/S1874-6047(06)80011-9

Identifiers

DOI

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5 September 2017

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