(Q38710987)

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TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

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scholarly article

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13 March 2020

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28334913%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

amyotrophic lateral sclerosis

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RNA-binding proteins

1 reference

based on heuristic

inferred from title

Alexandra Grubman

2

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13 March 2020

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13 March 2020

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13 March 2020

Bradley J Turner

10

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13 March 2020

Mercedes Prudencio

11

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13 March 2020

Peter J. Crouch

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13 March 2020

author name string

Diane Moujalled

1

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13 March 2020

Karla Acevedo

3

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13 March 2020

Donia M Moujalled

6

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13 March 2020

Clare Duncan

7

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13 March 2020

Aphrodite Caragounis

8

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13 March 2020

Nirma D Perera

9

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13 March 2020

Jeffrey R Liddell

16

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13 March 2020

Anthony R White

17

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13 March 2020

Leonard Petrucelli

12

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13 March 2020

publication date

1 May 2017

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13 March 2020

Human Molecular Genetics

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13 March 2020

26

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13 March 2020

9

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13 March 2020

1732-1746

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13 March 2020

Amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

The changing scene of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

TAR DNA-binding protein 43 in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Molecular neuropathology of TDP-43 proteinopathies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

hnRNPA2/B1 Function in Neurodegeneration: It's a Gain, Not a Loss.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Oxidative stress in ALS: key role in motor neuron injury and therapeutic target

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Mechanisms underlying inflammation in neurodegeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

hnRNP K: one protein multiple processes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Heterogeneous nuclear ribonucleoprotein (HnRNP) K genome-wide binding survey reveals its role in regulating 3'-end RNA processing and transcription termination at the early growth response 1 (EGR1) gene through XRN2 exonuclease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Glutathione Peroxidase Overexpression Inhibits CytochromecRelease and Proapoptotic Mediators to Protect Neurons From Experimental Stroke

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Glutathione in defense and signaling: lessons from a small thiol

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Modulation of oxidative stress as an anticancer strategy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Signaling from cAMP/PKA to MAPK and synaptic plasticity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Regulation of neuroendocrine differentiation by AKT/hnRNPK/AR/β-catenin signaling in prostate cancer cells.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

hnRNP K post-transcriptionally co-regulates multiple cytoskeletal genes needed for axonogenesis.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Characterization of hnRNP K protein-RNA interactions.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Motor cortex glutathione deficit in ALS measured in vivo with the J-editing technique

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Functional diversity of the hnRNPs: past, present and perspectives

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX093

21 January 2018

Identifiers

10.1093/HMG/DDX093

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28334913%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28334913%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

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