(Q38717942)

English

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes

scientific article published on 17 January 2014

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scholarly article

1 reference

Europe PubMed Central

5 September 2017

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes (English)

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Europe PubMed Central

5 September 2017

18

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1 June 2020

author name string

Markus Haberger

1

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1 June 2020

Katrin Bomans

2

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1 June 2020

Katharina Diepold

3

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1 June 2020

Michaela Hook

4

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1 June 2020

Jana Gassner

5

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1 June 2020

Tilman Schlothauer

6

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1 June 2020

Adrian Zwick

7

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1 June 2020

Christian Spick

8

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1 June 2020

Jochen Felix Kepert

9

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1 June 2020

Brigitte Hienz

10

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1 June 2020

Michael Wiedmann

11

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1 June 2020

Hermann Beck

12

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1 June 2020

Philipp Metzger

13

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1 June 2020

Michael Mølhøj

14

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1 June 2020

Constanze Knoblich

15

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1 June 2020

Ulla Grauschopf

16

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1 June 2020

Dietmar Reusch

17

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1 June 2020

publication date

17 January 2014

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Europe PubMed Central

5 September 2017

Monoclonal Antibodies

1 reference

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1 June 2020

6

1 reference

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1 June 2020

2

1 reference

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1 June 2020

327-339

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24441081%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Developability studies before initiation of process development: improving manufacturability of monoclonal antibodies

1 reference

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6 September 2017

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

1 reference

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6 September 2017

Characterization of therapeutic antibodies and related products.

1 reference

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6 September 2017

Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept

1 reference

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6 September 2017

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies.

1 reference

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6 September 2017

Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures

1 reference

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6 September 2017

Identification of potential sites for tryptophan oxidation in recombinant antibodies using tert-butylhydroperoxide and quantitative LC-MS

1 reference

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6 September 2017

Assessing monoclonal antibody product quality attribute criticality through clinical studies

1 reference

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6 September 2017

Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides

1 reference

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6 September 2017

Strategies and challenges for the next generation of therapeutic antibodies

1 reference

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6 September 2017

Design of therapeutic proteins with enhanced stability.

1 reference

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6 September 2017

Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods

1 reference

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6 September 2017

Antibody structure, instability, and formulation

1 reference

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6 September 2017

Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization.

1 reference

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6 September 2017

Biological significance of isoaspartate and its repair system

1 reference

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6 September 2017

Oxidative degradation of pharmaceuticals: theory, mechanisms and inhibition

1 reference

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6 September 2017

Molecular clocks

1 reference

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6 September 2017

Kabat Database and its applications: 30 years after the first variability plot

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6 September 2017

Non-enzymic post-translational modification of proteins in aging. A review

1 reference

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6 September 2017

Does the chemical instability of aspartyl and asparaginyl residues in proteins contribute to erythrocyte aging? The role of protein carboxyl methylation reactions.

1 reference

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6 September 2017

Isomerization of a single aspartyl residue of anti-epidermal growth factor receptor immunoglobulin gamma2 antibody highlights the role avidity plays in antibody activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

14 September 2017

Identification and characterization of deamidation sites in the conserved regions of human immunoglobulin gamma antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

14 September 2017

Isomerization of an aspartic acid residue in the complementarity-determining regions of a recombinant antibody to human IgE: identification and effect on binding affinity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

23 June 2018

Asparagine deamidation dependence on buffer type, pH, and temperature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

31 August 2018

8(th) Annual European Antibody Congress 2012: November 27-28, 2012, Geneva, Switzerland.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

31 August 2018

Analytical protein a chromatography as a quantitative tool for the screening of methionine oxidation in monoclonal antibodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

31 August 2018

Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

31 August 2018

Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

31 August 2018

Characterization of site-specific glycation during process development of a human therapeutic monoclonal antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

31 August 2018

Identification of isomerization and racemization of aspartate in the Asp-Asp motifs of a therapeutic protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

31 August 2018

Identification and characterization of oxidation and deamidation sites in monoclonal rat/mouse hybrid antibodies

1 reference

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31 August 2018

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

31 August 2018

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

31 August 2018

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: mechanisms and stabilization

1 reference

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31 August 2018

Impact of methionine oxidation on the binding of human IgG1 to Fc Rn and Fc gamma receptors

1 reference

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31 August 2018

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

1 reference

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31 August 2018

Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization.

1 reference

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31 August 2018

Glycation during storage and administration of monoclonal antibody formulations

1 reference

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31 August 2018

Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation.

1 reference

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31 August 2018

Unveiling a glycation hot spot in a recombinant humanized monoclonal antibody

1 reference

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31 August 2018

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: where it is, how it got there, and how it affects charge-based behavior

1 reference

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31 August 2018

Characterization of nonenzymatic glycation on a monoclonal antibody

1 reference

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31 August 2018

Identification of a single tryptophan residue as critical for binding activity in a humanized monoclonal antibody against respiratory syncytial virus

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31 August 2018

Heterogeneity of recombinant antibodies: linking structure to function

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31 August 2018

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

1 reference

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31 August 2018

Identification of multiple sources of charge heterogeneity in a recombinant antibody.

1 reference

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31 August 2018

The kinetics of relaxin oxidation by hydrogen peroxide

1 reference

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31 August 2018

Comparison of methionine oxidation in thermal stability and chemically stressed samples of a fully human monoclonal antibody

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Determination of protein oxidation by mass spectrometry and method transfer to quality control

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441081

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple forms of cytochrome c in the rat. Precursor-product relationship between the main component Cy I and the minor components Cy II and Cy 3 in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441081

12 December 2020

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inferred from PubMed ID database lookup

Chemical and physical stability of chimeric L6, a mouse-human monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441081

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of sites of degradation in a therapeutic monoclonal antibody by peptide mapping

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441081

12 December 2020

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inferred from PubMed ID database lookup

Rates and impact of human antibody glycation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441081

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidants for prevention of methionine oxidation in recombinant monoclonal antibody HER2

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441081

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/MABS.27876

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24441081%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24441081%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24441081%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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