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Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils.
scientific article published on 16 June 2017
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Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
title
Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils
(English)
1 reference
stated in
Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
author
Ansgar B Siemer
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
author name string
J Mario Isas
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1
1 reference
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Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
Andreas Langen
series ordinal
2
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5575822
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
Myles C Isas
series ordinal
3
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Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
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23 March 2020
Nitin K Pandey
series ordinal
4
1 reference
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Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
language of work or name
English
0 references
publication date
7 July 2017
1 reference
stated in
Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
published in
Biochemistry
1 reference
stated in
Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
volume
56
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Europe PubMed Central
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5575822
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
issue
28
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Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
page(s)
3579-3586
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Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
cites work
Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core
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PubMed Central
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Huntingtin exon 1 fibrils feature an interdigitated β-hairpin-based polyglutamine core
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A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast.
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Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils
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Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
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Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells
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Single homopolypeptide chains collapse into mechanically rigid conformations
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Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity
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Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy
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Alanine scanning mutagenesis of Abeta(1-40) amyloid fibril stability
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Diseases of unstable repeat expansion: mechanisms and common principles
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Thermodynamics of A beta(1-40) amyloid fibril elongation
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New model for crystalline polyglutamine assemblies and their connection with amyloid fibrils
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Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease
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Identifiers
DOI
10.1021/ACS.BIOCHEM.7B00138
1 reference
stated in
Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
PMCID
5575822
1 reference
stated in
Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
PubMed ID
28621522
1 reference
stated in
Europe PubMed Central
PMCID
5575822
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 March 2020
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