(Q44530908)

English

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease

scientific article published on 29 July 2003

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scholarly article

1 reference

Europe PubMed Central

3 December 2017

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease (English)

1 reference

Europe PubMed Central

3 December 2017

Huntington's disease

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6

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Europe PubMed Central

3 December 2017

5

object named as

Hans Lehrach

1 reference

Europe PubMed Central

3 December 2017

Sabine Engemann

2

object named as

Sabine Engemann

1 reference

Europe PubMed Central

3 December 2017

3

object named as

Rudi Lurz

1 reference

Europe PubMed Central

3 December 2017

author name string

Anne Busch

1

1 reference

Europe PubMed Central

3 December 2017

Hitoshi Okazawa

4

1 reference

Europe PubMed Central

3 December 2017

language of work or name

0 references

publication date

29 July 2003

1 reference

Europe PubMed Central

3 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

3 December 2017

278

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Europe PubMed Central

3 December 2017

41452-41461

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Europe PubMed Central

3 December 2017

42

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Europe PubMed Central

3 December 2017

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Loss of normal huntingtin function: new developments in Huntington's disease research

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

PQBP-1 (Np/PQ): a polyglutamine tract-binding and nuclear inclusion-forming protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303354200

21 January 2018

Identifiers

10.1074/JBC.M303354200

1 reference

Europe PubMed Central

3 December 2017

1 reference

Europe PubMed Central

3 December 2017

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