(Q38724337)

5 September 2017

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title

TGF-β: the connecting link between nephropathy and fibrosis (English)

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5 September 2017

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Brijesh Sutariya

1

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5 September 2017

Dimple Jhonsa

series ordinal

2

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5 September 2017

Madhusudan N Saraf

series ordinal

3

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5 September 2017

publication date

1 February 2016

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Immunopharmacology and Immunotoxicology

5 September 2017

published in

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5 September 2017

volume

38

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5 September 2017

issue

1

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5 September 2017

page(s)

39-49

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TGF-beta signal transduction in chronic kidney disease

5 September 2017

cites work

1 reference

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Diverse roles of TGF-β/Smads in renal fibrosis and inflammation

21 January 2018

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21 January 2018

TGF-beta and fibrosis

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The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy

21 January 2018

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Structural-functional relationships in diabetic nephropathy

21 January 2018

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New insights into epithelial-mesenchymal transition in kidney fibrosis

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Renal fibroblasts and myofibroblasts in chronic kidney disease

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Epithelial-mesenchymal Transition and Cell Invasion

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Early epithelial phenotypic changes predict graft fibrosis

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Evidence that fibroblasts derive from epithelium during tissue fibrosis

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

TGF-beta signal transduction and mesangial cell fibrogenesis

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Renal fibrosis: novel insights into mechanisms and therapeutic targets.

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside?

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

The basics of epithelial-mesenchymal transition

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

The contribution of epithelial-mesenchymal transition to renal fibrosis differs among kidney disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Transcriptional control by the TGF-beta/Smad signaling system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

New insights of epithelial-mesenchymal transition in cancer metastasis

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-beta1-dependent mechanism in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Epithelial-to-mesenchymal transition and oxidative stress in chronic allograft nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Latent TGF-beta binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Latency, activation, and binding proteins of TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

The regulation of TGFbeta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Smad transcription factors

21 January 2018

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https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Ski and SnoN: negative regulators of TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Smad3-mediated upregulation of miR-21 promotes renal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Identification of novel long noncoding RNAs associated with TGF-β/Smad3-mediated renal inflammation and fibrosis by RNA sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Non-Smad TGF-beta signals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Regulation of TGF-beta1/MAPK-mediated PAI-1 gene expression by the actin cytoskeleton in human mesangial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Growth factors and mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

TGF-beta-induced epithelial to mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Regulation of notch signaling activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Notch signaling is necessary for epithelial growth arrest by TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

TGF-beta signaling in renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Wnt/β-catenin signaling and kidney fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

ILK, PINCH and parvin: the tIPP of integrin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Global and societal implications of the diabetes epidemic

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

TGF-beta in diabetic kidney disease: role of novel signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Role of advanced glycation end products in diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Glucose-induced changes in integrins and matrix-related functions in cultured human glomerular epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Circulating TGF-β1-Regulated miRNAs and the Risk of Rapid Progression to ESRD in Type 1 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Loss of MicroRNA-192 promotes fibrogenesis in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Activation of nuclear factor-kappa B by podocytes in the autologous phase of passive Heymann nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Activation of the TGF-beta/Smad signaling pathway in focal segmental glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Chronic renal diseases as a public health problem: epidemiology, social, and economic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Plasmin(ogen) Promotes Renal Interstitial Fibrosis by Promoting Epithelial-to-Mesenchymal Transition: Role of Plasmin-Activated Signals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

Nonimmunosuppressive therapy of membranous nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08923973.2015.1127382

10.3109/08923973.2015.1127382

21 January 2018

Identifiers

DOI

1 reference

5 September 2017

1 reference