(Q38735132)

6 September 2017

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein (English)

1 reference

6 September 2017

18

Gabriela Chiosis

0 references

Hediye Erdjument-Bromage

15

object named as

Hediye Erdjument-Bromage

0 references

author name string

Anna Rodina

1

1 reference

6 September 2017

Pallav D Patel

2

1 reference

6 September 2017

Yanlong Kang

3

1 reference

6 September 2017

Yogita Patel

4

1 reference

6 September 2017

Imad Baaklini

5

1 reference

6 September 2017

Michael J H Wong

6

1 reference

6 September 2017

Tony Taldone

7

1 reference

6 September 2017

Pengrong Yan

8

1 reference

6 September 2017

Chenghua Yang

9

1 reference

6 September 2017

Ronnie Maharaj

10

1 reference

6 September 2017

Alexander Gozman

11

1 reference

6 September 2017

Maulik R Patel

12

1 reference

6 September 2017

Hardik J Patel

13

1 reference

6 September 2017

William Chirico

14

1 reference

6 September 2017

Tanaji T Talele

16

1 reference

6 September 2017

Jason C Young

17

1 reference

6 September 2017

14 November 2013

1 reference

6 September 2017

Chemistry and Biology

1 reference

6 September 2017

20

1 reference

6 September 2017

12

1 reference

6 September 2017

1469-1480

1 reference

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

The VSGB 2.0 model: a next generation energy model for high resolution protein structure modeling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

The resurgence of covalent drugs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

ATP-induced conformational changes in Hsp70: molecular dynamics and experimental validation of an in silico predicted conformation.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Pharmacological targeting of the Hsp70 chaperone

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Identifying and characterizing binding sites and assessing druggability

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Allostery in Hsp70 chaperones is transduced by subdomain rotations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Crystal structure of the C-terminal three-helix bundle subdomain of C. elegans Hsp70

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

All are not equal: a benchmark of different homology modeling programs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Hsp70 chaperones: cellular functions and molecular mechanism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Pathways of chaperone-mediated protein folding in the cytosol

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Hsp70 and Hsp90--a relay team for protein folding

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Structural analysis of substrate binding by the molecular chaperone DnaK

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Structural basis of the 70-kilodalton heat shock cognate protein ATP hydrolytic activity. II. Structure of the active site with ADP or ATP bound to wild type and mutant ATPase fragment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Functional divergence between co-chaperones of Hsc70.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

The DNAJA2 substrate release mechanism is essential for chaperone-mediated folding

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Identification of Hsp70 modulators through modeling of the substrate binding domain.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Quantitative recovery of biotinylated proteins from streptavidin-based affinity chromatography resins

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985611

Hsp70: anti-apoptotic and tumorigenic protein

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24239008

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

N-Ethylmaleimide inactivates a nucleotide-free Hsp70 molecular chaperone

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24239008

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2013.10.008

1 reference

6 September 2017

1 reference

6 September 2017

1 reference