(Q38745849)

10 June 2018

title

Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors (English)

1 reference

10 June 2018

0 references

Timothy A Marlowe

1

1 reference

10 June 2018

Felicia L Lenzo

2

1 reference

10 June 2018

Sheila A Figel

3

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10 June 2018

Abigail T Grapes

4

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10 June 2018

William G Cance

5

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10 June 2018

publication date

16 September 2016

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10 June 2018

Molecular Cancer Therapeutics

published in

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10 June 2018

volume

15

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10 June 2018

issue

12

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10 June 2018

page(s)

3028-3039

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10 June 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5136315/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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23 June 2018

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23 June 2018

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23 June 2018

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23 June 2018

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23 June 2018

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A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth

23 June 2018

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Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer

23 June 2018

1 reference

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23 June 2018

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23 June 2018

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A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

23 June 2018

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23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

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23 June 2018

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23 June 2018

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Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53

23 June 2018

1 reference

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23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

23 June 2018

1 reference

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Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

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23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

FAK integrates growth-factor and integrin signals to promote cell migration

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Association of focal adhesion kinase with Grb7 and its role in cell migration

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136315

Expression of focal adhesion kinase gene and invasive cancer

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27638858

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27638858

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1535-7163.MCT-16-0366

1 reference

10 June 2018

PMC publication ID

5136315

1 reference

10 June 2018

PubMed publication ID

27638858

1 reference

10 June 2018