(Q36216076)

12 August 2017

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title

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity (English)

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12 August 2017

Neil O Carragher

2

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Margaret Frame

object named as

Margaret C Frame

series ordinal

6

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Valerie G Brunton

series ordinal

5

object named as

Valerie G Brunton

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12 August 2017

3

Egle Avizienyte

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12 August 2017

1

Gordon W McLean

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12 August 2017

Jeff Evans

4

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12 August 2017

language of work or name

English

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publication date

1 July 2005

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12 August 2017

published in

Nature Reviews Cancer

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12 August 2017

volume

5

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12 August 2017

issue

7

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12 August 2017

page(s)

505-515

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Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

12 August 2017

cites work

1 reference

Expression of focal adhesion kinase gene and invasive cancer

31 March 2020

1 reference

Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer

31 March 2020

1 reference

Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma

31 March 2020

1 reference

Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

31 March 2020

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Focal adhesion kinase expression in oral cancers

31 March 2020

1 reference

Focal adhesion kinase and its potential involvement in tumor invasion and metastasis

31 March 2020

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Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma.

31 March 2020

1 reference

Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis

31 March 2020

1 reference

Control of motile and invasive cell phenotypes by focal adhesion kinase.

31 March 2020

1 reference

Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion

31 March 2020

1 reference

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

31 March 2020

1 reference

Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites

31 March 2020

1 reference

Focal adhesion kinase: in command and control of cell motility

31 March 2020

1 reference

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

31 March 2020

1 reference

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

31 March 2020

1 reference

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

31 March 2020

1 reference

Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

31 March 2020

1 reference

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

31 March 2020

1 reference

Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples

31 March 2020

1 reference

Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in squamous cell carcinoma of the larynx

31 March 2020

1 reference

Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior

31 March 2020

1 reference

FAK integrates growth-factor and integrin signals to promote cell migration

31 March 2020

1 reference

Expression of GRP and its receptor in well-differentiated colon cancer cells correlates with the presence of focal adhesion kinase phosphorylated at tyrosines 397 and 407.

31 March 2020

1 reference

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

31 March 2020

1 reference

Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.

31 March 2020

1 reference

Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation

31 March 2020

1 reference

Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies

31 March 2020

1 reference

Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts

31 March 2020

1 reference

Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement

31 March 2020

1 reference

Differential regulation of cell motility and invasion by FAK

31 March 2020

1 reference

A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.

31 March 2020

1 reference

FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

31 March 2020

1 reference

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

31 March 2020

1 reference

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

31 March 2020

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Isoform specific function of calpain 2 in regulating membrane protrusion

31 March 2020

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Regulation of cell migration by the calcium-dependent protease calpain

31 March 2020

1 reference

Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin

31 March 2020

1 reference

Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.

31 March 2020

1 reference

Calpain-mediated proteolysis of talin regulates adhesion dynamics

31 March 2020

1 reference

Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation

31 March 2020

1 reference

SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling

31 March 2020

1 reference

Development of anticancer drugs targeting the MAP kinase pathway

31 March 2020

1 reference

DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling

31 March 2020

1 reference

Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type

31 March 2020

1 reference

Focal adhesion kinase as a potential target in oncology

31 March 2020

1 reference

Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase

31 March 2020

1 reference

JNK phosphorylates paxillin and regulates cell migration

31 March 2020

1 reference

Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility.

31 March 2020

1 reference

Biochemical signals and biological responses elicited by the focal adhesion kinase

31 March 2020

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Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

31 March 2020

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FAK promotes organization of fibronectin matrix and fibrillar adhesions.

31 March 2020

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Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells

31 March 2020

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Direct Interaction of Focal Adhesion Kinase with p190RhoGEF

31 March 2020

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The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly

31 March 2020

1 reference

An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

31 March 2020

1 reference

Focal adhesion kinase: the first ten years

31 March 2020

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Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

31 March 2020

1 reference

Focal adhesion kinase regulation of N-WASP subcellular localization and function

31 March 2020

1 reference

v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion

31 March 2020

1 reference

Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase

31 March 2020

1 reference

Taking cell-matrix adhesions to the third dimension

31 March 2020

1 reference

Dimensions and dynamics in integrin function

31 March 2020

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Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro

31 March 2020

1 reference

v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts

31 March 2020

1 reference

A role for focal adhesion kinase in hyluronan-dependent MMP-2 secretion in a human small-cell lung carcinoma cell line, QG90.

31 March 2020

1 reference

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis

31 March 2020

1 reference

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

31 March 2020

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Tumour-cell invasion and migration: diversity and escape mechanisms

31 March 2020

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Prespecification and plasticity: shifting mechanisms of cell migration

31 March 2020

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Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion

31 March 2020

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Transforming growth factor beta regulates cell-cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells

31 March 2020

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Endothelial barrier strengthening by activation of focal adhesion kinase.

31 March 2020

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Control of adhesion-dependent cell survival by focal adhesion kinase

31 March 2020

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Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cells

31 March 2020

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Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60.

31 March 2020

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Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G.

31 March 2020

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Apoptosis of rat hepatic stellate cells induced by anti-focal adhesion kinase antibody

31 March 2020

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Inhibition of pp125FAK in cultured fibroblasts results in apoptosis

31 March 2020

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Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury

31 March 2020

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Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

31 March 2020

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Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells

31 March 2020

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The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways.

31 March 2020

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Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis

31 March 2020

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Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein

31 March 2020

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Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

31 March 2020

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RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity

31 March 2020

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

31 March 2020

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Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo

31 March 2020

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Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells

31 March 2020

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Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

31 March 2020

1 reference

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

31 March 2020

1 reference

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

31 March 2020

1 reference

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

31 March 2020

1 reference

Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts

31 March 2020

1 reference

Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine

31 March 2020

1 reference

Tumor promotion by abrasion induced epidermal hyperplasia in the skin of mice

31 March 2020

1 reference

FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma

31 March 2020

1 reference

Src inhibitors: genomics to therapeutics

31 March 2020

1 reference

Selective GRB2 SH2 inhibitors as anti-Ras therapy

31 March 2020

1 reference

Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases

31 March 2020

1 reference

Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition

31 March 2020

1 reference

Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase

31 March 2020

1 reference

FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth

31 March 2020

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Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1647

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12 August 2017

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