(Q34293560)

1 August 2017

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title

Development of anticancer drugs targeting the MAP kinase pathway (English)

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1 August 2017

J S Sebolt-Leopold

1

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1 August 2017

language of work or name

English

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publication date

1 December 2000

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1 August 2017

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1 August 2017

19

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1 August 2017

6594-6599

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1 August 2017

56

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204083

1 August 2017

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cites work

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

The ins and outs of Raf kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

A synthetic inhibitor of the mitogen-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Isotype-specific functions of Raf kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Paradoxical activation of Raf by a novel Raf inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Transcriptional regulation by extracellular signals: mechanisms and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Protein kinase C alpha activates RAF-1 by direct phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: high-throughput screening and identification of selective enzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Phase I clinical/pharmacokinetic and pharmacodynamic trial of the c-raf-1 antisense oligonucleotide ISIS 5132 (CGP 69846A).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Bcl-2 targets the protein kinase Raf-1 to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

7 January 2021

Activation of ternary complex factor Elk-1 by MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

7 January 2021

Signal transduction through MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204083

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204083

1 reference

Dimensions Publication ID

1 August 2017

1044594511

0 references

Fatcat ID

release_zallrvmvujb4nc7cb76jnkyqze

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zallrvmvujb4nc7cb76jnkyqze

24 November 2022

mapped directly with Wikidata item

1 reference