(Q34481586)

2 August 2017

1 reference

title

Src inhibitors: genomics to therapeutics (English)

1 reference

2 August 2017

1 reference

Sawyer T

1

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2 August 2017

Boyce B

series ordinal

2

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2 August 2017

Dalgarno D

series ordinal

3

1 reference

2 August 2017

Iuliucci J

series ordinal

4

1 reference

2 August 2017

language of work or name

English

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publication date

1 July 2001

1 reference

Expert Opinion on Investigational Drugs

2 August 2017

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2 August 2017

10

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2 August 2017

7

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2 August 2017

1327-1344

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Cellular functions regulated by Src family kinases

2 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Identification of a transformation-specific antigen induced by an avian sarcoma virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Identification of a polypeptide encoded by the avian sarcoma virus src gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Protein kinase activity associated with the avian sarcoma virus src gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Tyrosine kinase inhibition: an approach to drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Protein kinase inhibitors: the tyrosine-specific protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Kinase inhibitors in cancer therapy: a look ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Co-operative effect of c-Src tyrosine kinase and Stat3 in activation of hepatocyte growth factor expression in mammary carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

New roles for Src kinases in control of cell survival and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Activating SRC mutation in a subset of advanced human colon cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

A siren song from tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Decreased c-Src expression enhances osteoblast differentiation and bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Tyrosine phosphorylation of cortactin is required for H2O2-mediated injury of human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Angiotensin II mediated signal transduction. Important role of tyrosine kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Activation of extracellular signal-regulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Src tyrosine kinases and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases mediate pressure-induced c-fos expression in cannulated rat mesenteric small arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

In vitro and in vivo suppression of osteoclast function by adenovirus vector-induced csk gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Design of allele-specific inhibitors to probe protein kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

A tail of two src's: mutatis mutandis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Structure-function relationships in Src family and related protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Src family protein tyrosine kinases and cellular signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Proline-rich sequences that bind to Src homology 3 domains with individual specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Design and synthesis of SH3 domain binding ligands: modifications of the consensus sequence XPpXP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Recent advances in the design and synthesis of SH2 inhibitors of Src, Grb2 and ZAP-70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Progress in the development of inhibitors of SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

A Src SH2 selective binding compound inhibits osteoclast-mediated resorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

From consensus sequence peptide to high affinity ligand, a "library scan" strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

SH2-directed ligands of the Lck tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

The marine natural product, halistanol trisulfate, inhibits pp60v-src protein tyrosine kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographical constraints in peptide design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Therapeutic approaches to bone diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Emerging therapies for the prevention or treatment of postmenopausal osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Immunotherapy in atopic dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

The parathyroid hormone, its fragments and analogues--potent bone-builders for treating osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Ligands for the Tyrosine Kinase p56lckSH2 Domain: Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

Cyclin-Dependent Kinase Inhibition by New C-2 Alkynylated Purine Derivatives and Molecular Structure of a CDK2−Inhibitor Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.10.7.1327

10.1517/13543784.10.7.1327

21 January 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference