(Q38752732)

20 June 2018

title

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans (English)

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genome-wide association study

main subject

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67

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Bruna Gigante

109

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Torben Hansen

138

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Paul W. Franks

150

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Julia Meyer

Julia Meyer

99

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Tune H Pers

Tune H Pers

8

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Rafn Benediktsson

Rafn Benediktsson

48

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Damiano Baldassarre

Damiano Baldassarre

94

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Josée Dupuis

Josée Dupuis

171

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Elena Tremoli

Elena Tremoli

97

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Oluf Borbye Pedersen

Oluf Pedersen

139

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Tim Frayling

Timothy M Frayling

128

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Karen L Mohlke

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Karen L Mohlke

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168

Frank B Hu

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165

Andres Metspalu

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Tõnu Esko

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131

Veikko Salomaa

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115

Matthias Blüher

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Man Li

35

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Ching-Ti Liu

Ching-Ti Liu

61

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Andrew Tym Hattersley

Andrew T Hattersley

129

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Augustine Kong

Augustine Kong

50

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Mark McCarthy

Mark I McCarthy

174

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Michael Stumvoll

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Michael Stumvoll

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157

Nicholas J Wareham

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Michael Boehnke

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Anne U Jackson

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Ruth J F Loos

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Erwin P Bottinger

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Erik Ingelsson

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Eric Boerwinkle

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PMCID

5652602

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Yvonne T van der Schouw

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Yvonne T van der Schouw

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Heather M Stringham

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Lori L Bonnycastle

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Bengt Sennblad

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Karin Leander

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Anders Hamsten

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Lars Lind

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Stefan Gustafsson

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James B Meigs

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Valeriya Lyssenko

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Bo Isomaa

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Rob M van Dam

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PMCID

5652602

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Christian Fuchsberger

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Christian Fuchsberger

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David Altshuler

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Domenico Palli

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Kári Stefánsson

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Kari Stefansson

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David J. Hunter

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David J Hunter

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Konstantin Strauch

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Konstantin Strauch

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Lu Qi

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Sonali Pechlivanis

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Karl-Heinz Jöckel

121

Karl-Heinz Jöckel

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Susanne Moebus

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Susanne Moebus

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Raimund Erbel

120

Raimund Erbel

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Norman Klopp

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Norman Klopp

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Evelin Mihailov

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Evelin Mihailov

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Peter Almgren

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Peter Almgren

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Tanya M Teslovich

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Tanya M Teslovich

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Richard N. Bergman

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Richard N Bergman

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Loic Yengo

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Loic Yengo

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Michael Roden

56

Michael Roden

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Johan G. Eriksson

102

Johan G Eriksson

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Caroline S. Fox

60

Caroline Fox

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Nancy Pedersen

132

Nancy L Pedersen

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Leena Peltonen-Palotie

104

Leena Peltonen

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Peter Kovacs

116

Peter Kovacs

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Robert A Scott

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Robert A Scott

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Andrew R Wood

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Andrew R Wood

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Gonçalo Abecasis

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Goncalo R Abecasis

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Peter S Chines

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Peter S Chines

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Marilyn C Cornelis

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Marilyn C Cornelis

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Kyle J Gaulton

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Kyle J Gaulton

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Christian T Have

69

Christian T Have

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Heikki A. Koistinen

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Heikki A Koistinen

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Markus M Nöthen

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Markus M Nöthen

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Stephen E Humphries

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Steve E Humphries

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Douglas M. Ruderfer

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Douglas Ruderfer

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Laura Scott

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Laura J Scott

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Thomas Sparsø

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Thomas Sparso

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Dorothée Thuillier

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Dorothee Thuillier

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Mattias Frånberg

46

Mattias Frånberg

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Himanshu Chheda

43

Himanshu Chheda

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Lewin Eisele

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Lewin Eisele

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Elisabeth van Leeuwen

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Elisabeth M van Leeuwen

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Phoenix Kwan

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Phoenix Kwan

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Guillaume Charpentier

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Guillaume Charpentier

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Elodie Eury

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Elodie Eury

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Astradur B Hreidarsson

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Astradur B Hreidarsson

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Nicola D Kerrison

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Nicola D Kerrison

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Liming Liang

54

Liming Liang

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Olga McLeod

111

Olga McLeod

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Thomas W Mühleisen

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Thomas W Mühleisen

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Gerald Steinbach

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Gerald Steinbach

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Roman Wennauer

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Roman Wennauer

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Panos Deloukas

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Panagiotis Deloukas

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Stephane Cauchi

145

Stephane Cauchi

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Leif Groop

155

Leif C Groop

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DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium

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DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium

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Nigel William Rayner

26

Nigel W Rayner

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Natalia Pervjakova

7

Natalia Pervjakova

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Stéphane Lobbens

108

Stéphane Lobbens

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Janina S Ried

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Janina S Ried

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Christian Gieger

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Christian Gieger

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Nisa M. Maruthur

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Nisa M Maruthur

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Denis Rybin

62

Denis Rybin

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Leena Kinnunen

89

Leena Kinnunen

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Beverley Balkau

148

Beverley Balkau

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Reedik Mägi

3

Reedik Mägi

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Letizia Marullo

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Letizia Marullo

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Anke Tönjes

117

Anke Tonjes

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Karl Gertow

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Karl Gertow

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Natalie R van Zuydam

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Natalie R Van Zuydam

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J Peter Donnelly

127

Peter J Donnelly

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Emmi Tikkanen

105

Emmi Tikkanen

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Lars Lannfelt

141

Lars Lannfelt

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B O Boehm

133

Bernhard O Boehm

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Peter Kraft

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Peter Kraft

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172

Andrew P Morris

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Teresa Ferreira

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Teresa Ferreira

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Andrew D Morris

166

Andrew D Morris

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Longda Jiang

40

Longda Jiang

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Andrew D. Johnson

9

Andrew D Johnson

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20 June 2018

author name string

John D Eicher

10

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20 June 2018

Yeji Lee

13

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20 June 2018

Clement Ma

14

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20 June 2018

Han Chen

20

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Ben F Voight

22

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Neil Robertson

27

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20 June 2018

Sara M Willems

30

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20 June 2018

Pritam Chanda

34

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20 June 2018

Yingchang Lu

36

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20 June 2018

Christian Dina

37

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Gunnar Sigurðsson

51

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20 June 2018

Jian'an Luan

53

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20 June 2018

Thomas Meitinger

55

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20 June 2018

David J Couper

66

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20 June 2018

Qi Sun

77

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Katharine R Owen

79

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20 June 2018

Juan Tajes-Fernandes

83

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Satu Mӓnnistö

103

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Chiara Scapoli

119

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Samuli Ripatti

130

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Aurelio Barricarte Gurrea

151

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20 June 2018

Jose C Florez

160

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20 June 2018

John R B Perry

80

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20 June 2018

language of work or name

English

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publication date

31 May 2017

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20 June 2018

number of pages

15

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published in

Diabetes

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20 June 2018

volume

66

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20 June 2018

issue

11

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20 June 2018

page(s)

2888-2902

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20 June 2018

describes a project that uses

genome-wide association study

1 reference

based on heuristic

inferred from title

cites work

The genetic architecture of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility

23 June 2018

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Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

23 June 2018

1 reference

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The UK10K project identifies rare variants in health and disease

23 June 2018

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Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

23 June 2018

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Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

23 June 2018

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New genetic loci link adipose and insulin biology to body fat distribution

23 June 2018

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Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

23 June 2018

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Genetic and epigenetic fine mapping of causal autoimmune disease variants

23 June 2018

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Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

23 June 2018

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The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis

23 June 2018

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Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population

23 June 2018

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A central role for GRB10 in regulation of islet function in man.

23 June 2018

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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

23 June 2018

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Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms

23 June 2018

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Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

23 June 2018

1 reference

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Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.

23 June 2018

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Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

23 June 2018

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Evaluating empirical bounds on complex disease genetic architecture

23 June 2018

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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

23 June 2018

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Mendelian randomization analysis with multiple genetic variants using summarized data

23 June 2018

1 reference

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Discovery and refinement of loci associated with lipid levels

23 June 2018

1 reference

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An integrated map of genetic variation from 1,092 human genomes

23 June 2018

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Bayesian refinement of association signals for 14 loci in 3 common diseases

23 June 2018

1 reference

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An integrated encyclopedia of DNA elements in the human genome

23 June 2018

1 reference

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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

23 June 2018

1 reference

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Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

23 June 2018

1 reference

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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

23 June 2018

1 reference

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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

23 June 2018

1 reference

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Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci

23 June 2018

1 reference

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Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

23 June 2018

1 reference

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GCTA: a tool for genome-wide complex trait analysis

23 June 2018

1 reference

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mTOR: from growth signal integration to cancer, diabetes and ageing

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

A flexible and accurate genotype imputation method for the next generation of genome-wide association studies

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Gut hormones and the regulation of energy homeostasis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Type 2 diabetes: principles of pathogenesis and therapy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5652602

31 August 2018

Identifiers

DOI

10.2337/DB16-1253

1 reference

20 June 2018

PMCID

5652602

1 reference

20 June 2018

PubMed ID

28566273

1 reference

20 June 2018