(Q38770771)

6 September 2017

title

Celastrol targets IRAKs to block Toll-like receptor 4-mediated nuclear factor-κB activation (English)

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6 September 2017

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5

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ResearchGate publication ID

ResearchGate

23 September 2024

Yu-fan Shen

1

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6 September 2017

Xue Zhang

2

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6 September 2017

Ying Wang

3

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6 September 2017

Fan-fan Cao

4

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6 September 2017

Bin Peng

6

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6 September 2017

Deng-hai Zhang

7

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6 September 2017

publication date

1 May 2016

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Journal of Integrative Medicine

6 September 2017

published in

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6 September 2017

volume

14

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6 September 2017

issue

3

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6 September 2017

page(s)

203-208

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Tripterine inhibits the expression of adhesion molecules in activated endothelial cells.

6 September 2017

cites work

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Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study

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Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease

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Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice

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Targeting apoptosis pathways in cancer by Chinese medicine

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Naturally occurring NF-kappaB inhibitors

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Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production

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7 January 2021

Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid

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Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation

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Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family

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Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes

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Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages

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Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity

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Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation

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Hepatic TLR4 signaling in obese NAFLD

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Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1

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7 January 2021

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

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7 January 2021

IRAK signalling in cancer

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

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7 January 2021

10.1016/S2095-4964(16)60257-1

Identifiers

DOI

1 reference

6 September 2017

1 reference