(Q38776229)

English

Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers.

scientific article published on 15 May 2017

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20 March 2020

Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers (English)

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20 March 2020

Andrew D Cherniack

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Andrew D Cherniack

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Sang-Uk Han

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Jun Won Park

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Yang Liu

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Young Soo Park

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Ju Hee Kim

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Hanna Yang

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Hyejin Um

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Woo Ri Ko

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Byung Il Lee

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20 March 2020

Sun Young Kwon

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20 March 2020

Seung Wan Ryu

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20 March 2020

Chae Hwa Kwon

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20 March 2020

Do Youn Park

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20 March 2020

Jae-Hyuk Lee

14

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20 March 2020

Sang Il Lee

15

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20 March 2020

Kyu Sang Song

16

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20 March 2020

Heekyung Chang

19

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20 March 2020

Su-Jin Kim

20

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20 March 2020

Byung-Sik Kim

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20 March 2020

Jeong-Hwan Yook

22

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20 March 2020

Moon-Won Yoo

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20 March 2020

Beom-Su Kim

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20 March 2020

In-Seob Lee

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20 March 2020

Myeong-Cherl Kook

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20 March 2020

Nina Thiessen

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20 March 2020

An He

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20 March 2020

Andrew Dunford

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20 March 2020

Jaegil Kim

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Juliann Shih

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Steven Schumacher

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Amaro-Taylor Weiner

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Eun Gyeong Yang

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20 March 2020

Min-Hee Ryu

40

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20 March 2020

Adam J Bass

41

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20 March 2020

Hark Kyun Kim

42

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20 March 2020

Gordon Saksena

33

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20 March 2020

Gad Getz

38

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publication date

15 May 2017

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20 March 2020

Gastroenterology

1 reference

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20 March 2020

153

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20 March 2020

2

1 reference

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20 March 2020

536-549.e26

1 reference

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20 March 2020

Stomach carcinoma incidence patterns in the United States by histologic type and anatomic site

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gastric cancers in young and elderly patients show different genomic profiles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ROCK and Dia have opposing effects on adherens junctions downstream of Rho

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

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Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational processes molding the genomes of 21 breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-specific trends in incidence of noncardia gastric cancer in US adults.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CDH1/E-cadherin germline mutations in early-onset gastric cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

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Establishment and characterization of metastatic gastric cancer cell lines from murine gastric adenocarcinoma lacking Smad4, p53, and E-cadherin

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

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Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

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Transforming growth factor beta regulates cell-cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

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Comprehensive molecular characterization of gastric adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RecurrentRHOAmutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic Mutations and Deletions of the E-Cadherin Gene Predict Poor Survival of Patients With Gastric Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of CDH1 gene variants in early-onset diffuse gastric cancer in Chinese patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thinking outside the cell: how cadherins drive adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toward an Improved Definition of the Tumor Spectrum Associated WithBAP1Germline Mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of age on clinicopathological features and survival of patients with noncardia gastric adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Searching for E-cadherin gene mutations in early onset diffuse gastric cancer and hereditary diffuse gastric cancer in Korean patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mutations associated with aging-related rise in cancer incidence rates

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of demographic characteristics in 3242 young age gastric cancer patients in Korea

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28522256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1053/J.GASTRO.2017.05.012

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28522256%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

Europe PubMed Central

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20 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28522256%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

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