(Q38794254)

28489509

6 September 2017

title

AKT Inhibition in Solid Tumors With AKT1 Mutations (English)

1 reference

6 September 2017

5

1 reference

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9 June 2020

J Pérez Fidalgo

9

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9 June 2020

Justin Lindemann

23

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9 June 2020

Udai Banerji

30

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9 June 2020

4

Shannon N Westin

1 reference

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9 June 2020

32

Barry S Taylor

1 reference

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9 June 2020

author name string

David M Hyman

1

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9 June 2020

Lillian M Smyth

2

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9 June 2020

Mark T A Donoghue

3

1 reference

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9 June 2020

Emma J Dean

6

1 reference

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9 June 2020

Hideaki Bando

7

1 reference

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9 June 2020

Anthony B El-Khoueiry

8

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9 June 2020

Alain Mita

10

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9 June 2020

Jan H M Schellens

11

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9 June 2020

Matthew T Chang

12

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9 June 2020

Jonathan B Reichel

13

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9 June 2020

Nancy Bouvier

14

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9 June 2020

S Duygu Selcuklu

15

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9 June 2020

Tara E Soumerai

16

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9 June 2020

Jean Torrisi

17

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9 June 2020

Joseph P Erinjeri

18

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9 June 2020

Helen Ambrose

19

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9 June 2020

J Carl Barrett

20

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9 June 2020

Brian Dougherty

21

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9 June 2020

Andrew Foxley

22

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9 June 2020

Robert McEwen

24

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9 June 2020

Martin Pass

25

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9 June 2020

Gaia Schiavon

26

1 reference

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9 June 2020

Michael F Berger

27

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9 June 2020

Sarat Chandarlapaty

28

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9 June 2020

David B Solit

29

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9 June 2020

José Baselga

31

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9 June 2020

language of work or name

English

0 references

publication date

10 May 2017

1 reference

28489509

Journal of Clinical Oncology

6 September 2017

published in

1 reference

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9 June 2020

volume

35

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9 June 2020

issue

20

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9 June 2020

page(s)

2251-2259

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Prevalence of ESR1 Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer: A Secondary Analysis of the BOLERO-2 Clinical Trial

9 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Safety and tolerability of AZD5363 in Japanese patients with advanced solid tumors

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Drugging PI3K in cancer: refining targets and therapeutic strategies

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Crizotinib in ROS1-rearranged non-small-cell lung cancer.

31 August 2018

1 reference

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Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Development of PI3K inhibitors: lessons learned from early clinical trials

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

AKT1(E17K) in human solid tumours

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

Ras, PI(3)K and mTOR signalling controls tumour cell growth

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

The biology and clinical relevance of the PTEN tumor suppressor pathway

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

High frequency of mutations of the PIK3CA gene in human cancers

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501365

31 August 2018

Identifiers

DOI

10.1200/JCO.2017.73.0143

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489509%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

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9 June 2020

28489509

1 reference