(Q38797183)

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Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.

scientific article published on 8 November 2016

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27 March 2020

Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression (English)

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27 March 2020

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27 March 2020

Steven Rosenberg

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Steven A Rosenberg

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27 March 2020

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Maria Parkhurst

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27 March 2020

Anna Pasetto

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27 March 2020

Todd Prickett

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27 March 2020

Jessica S Crystal

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27 March 2020

Paul Robbins

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27 March 2020

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publication date

8 November 2016

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27 March 2020

Clinical Cancer Research

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27 March 2020

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27 March 2020

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27 March 2020

2491-2505

1 reference

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27 March 2020

Adoptive tumor therapy with T lymphocytes enriched through an IFN-gamma capture assay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant TCR-alpha requirements for a self antigen recognition in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant TCR V alpha usage by virus and tumor-reactive T cells with wide affinity ranges for their specific antigens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF/TNFR family members in costimulation of T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and use of conditional MHC class I ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer regression in patients after transfer of genetically engineered lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-specific Th17-polarized cells eradicate large established melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen spreading contributes to MAGE vaccination-induced regression of melanoma metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous isolation of CD8(+) and CD4(+) T cells specific for multiple viruses for broad antiviral immune reconstitution after allogeneic stem cell transplantation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simplified method of the growth of human tumor infiltrating lymphocytes in gas-permeable flasks to numbers needed for patient treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporation of transmembrane hydrophobic mutations in the TCR enhance its surface expression and T cell functional avidity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune epitope database analysis resource

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paths to stemness: building the ultimate antitumour T cell.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new cloning and expression system yields and validates TCRs from blood lymphocytes of patients with cancer within 10 days

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-reactive CD8+ T cells in metastatic gastrointestinal cancer refractory to chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Profiling the T-cell receptor repertoire of patient with pleural tuberculosis by high-throughput sequencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical-scale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of FNA samples for whole-exome sequencing and detection of somatic mutations in breast cancer surgical specimens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput pairing of T cell receptor α and β sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunogenicity of somatic mutations in human gastrointestinal cancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA sequences of two inducible T-cell genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-16-2680

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27827318%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27827318%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27827318%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

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