(Q38849205)

English

Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis.

scientific article published on 27 July 2015

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26212010%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis (English)

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20 February 2020

cancer metastasis

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Rosalía Cordo Russo

5

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20 February 2020

Juan Carlos Roa

13

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20 February 2020

Elisa Dora Bal De Kier Joffe

15

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20 February 2020

Patricia V Elizalde

18

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20 February 2020

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L Venturutti

1

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20 February 2020

L V Romero

2

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20 February 2020

A J Urtreger

3

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20 February 2020

M F Chervo

4

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20 February 2020

M F Mercogliano

6

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20 February 2020

G Inurrigarro

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20 February 2020

M G Pereyra

8

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20 February 2020

C J Proietti

9

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20 February 2020

F Izzo

10

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20 February 2020

M C Díaz Flaqué

11

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20 February 2020

V Sundblad

12

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20 February 2020

P Guzmán

14

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20 February 2020

E H Charreau

16

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20 February 2020

R Schillaci

17

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20 February 2020

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27 July 2015

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20 February 2020

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20 February 2020

35

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20 February 2020

17

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20 February 2020

2208-2222

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20 February 2020

The relationship between prognostic and predictive factors in the management of breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

HER2 therapy. HER2 (ERBB2): functional diversity from structurally conserved building blocks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Role of STAT3 in cancer metastasis and translational advances

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Progestin drives breast cancer growth by inducing p21(CIP1) expression through the assembly of a transcriptional complex among Stat3, progesterone receptor and ErbB-2.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

A microRNA expression signature of human solid tumors defines cancer gene targets

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

MicroRNA expression profiles in head and neck cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Patterns of known and novel small RNAs in human cervical cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

miR-21 plays a pivotal role in gastric cancer pathogenesis and progression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

MicroRNA expression profiles in serous ovarian carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

MicroRNA expression as risk biomarker of breast cancer metastasis: a pilot retrospective case-cohort study

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Stat3 activation is required for cellular transformation by v-src

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Choosing the right cell line for breast cancer research

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

A novel cis-acting element in Her2 promoter regulated by Stat3 in mammary cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

MicroRNA-21 in breast cancer: diagnostic and prognostic potential

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Technical considerations for studying cancer metastasis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

miR-21: a small multi-faceted RNA.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Distal ERBB2 promoter fragment displays specific transcriptional and nuclear binding activities in ERBB2 overexpressing breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN gene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

HER2 aberrations in cancer: implications for therapy

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https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

A critical review of HER2-positive gastric cancer evaluation and treatment: from trastuzumab, and beyond

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https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

Inhibition of invasion and metastasis by glypican-3 in a syngeneic breast cancer model.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

21 January 2018

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1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

31 March 2020

STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

31 March 2020

Antimetastatic effect of desmopressin in a mouse mammary tumor model

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.281

31 March 2020

Modulation of fibronectin expression and proteolytic activity associated with the invasive and metastatic phenotype in two new murine mammary tumor cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26212010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stat3 is required for anchorage-independent growth and metastasis but not for mammary tumor development downstream of the ErbB-2 oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/26212010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in the expression of PDCD4 in ductal carcinoma of the breast.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26212010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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