(Q38863134)

7 September 2017

The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice (English)

1 reference

4-methylumbelliferone beta-D-glucuronide

7 September 2017

1 reference

ChEBI release 2020-05-28

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27218304%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

N Nagy

2

1 reference

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7 June 2020

S M Ruppert

3

1 reference

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7 June 2020

V G Sunkari

4

1 reference

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7 June 2020

P L Marshall

5

1 reference

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7 June 2020

J A Gebe

6

1 reference

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7 June 2020

H D Ishak

7

1 reference

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7 June 2020

S G Keswani

8

1 reference

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7 June 2020

J Bollyky

9

1 reference

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7 June 2020

A R Frymoyer

10

1 reference

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7 June 2020

T N Wight

11

1 reference

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7 June 2020

L Steinman

12

1 reference

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7 June 2020

P L Bollyky

13

1 reference

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7 June 2020

publication date

24 May 2016

1 reference

Clinical and Experimental Immunology

7 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27218304%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

185

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7 June 2020

issue

3

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7 June 2020

page(s)

372-381

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27218304%20AND%20SRC:MED&resulttype=core&format=json

Hyaluronan as an immune regulator in human diseases.

7 June 2020

cites work

1 reference

Hyaluronan--magic glue for the regulation of the immune response?

21 January 2018

1 reference

Hyaluronan: its nature, distribution, functions and turnover

21 January 2018

1 reference

The structure and function of hyaluronan: An overview

21 January 2018

1 reference

Serum hyaluronan concentration as a marker of angiopathy in patients with diabetes mellitus.

21 January 2018

1 reference

Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance.

21 January 2018

1 reference

Extracellular superoxide dismutase inhibits inflammation by preventing oxidative fragmentation of hyaluronan

21 January 2018

1 reference

Sputum hyaluronan and versican in severe eosinophilic asthma

21 January 2018

1 reference

Role of hyaluronan and hyaluronan-binding proteins in human asthma

21 January 2018

1 reference

Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis.

21 January 2018

1 reference

The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation

21 January 2018

1 reference

Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

21 January 2018

1 reference

Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis

21 January 2018

1 reference

Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types

21 January 2018

1 reference

Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization

21 January 2018

1 reference

The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis.

21 January 2018

1 reference

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

21 January 2018

1 reference

Hyaluronan fragments act as an endogenous danger signal by engaging TLR2.

21 January 2018

1 reference

Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages

21 January 2018

1 reference

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

21 January 2018

1 reference

Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44.

21 January 2018

1 reference

Hyaluronan fragments stimulate endothelial recognition of injury through TLR4.

21 January 2018

1 reference

Hyaluronan synthesis is required for IL-2-mediated T cell proliferation

21 January 2018

1 reference

Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration

21 January 2018

1 reference

Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.

21 January 2018

1 reference

The role of hyaluronan degradation products as innate alloimmune agonists.

21 January 2018

1 reference

CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta

21 January 2018

1 reference

Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors.

21 January 2018

1 reference

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells.

21 January 2018

1 reference

Hyaluronan binding identifies the most proliferative activated and memory T cells.

21 January 2018

1 reference

Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration

21 January 2018

1 reference

CD44 regulates survival and memory development in Th1 cells

21 January 2018

1 reference

4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer

21 January 2018

1 reference

Inhibition of hyaluronan synthesis accelerates murine atherosclerosis: novel insights into the role of hyaluronan synthesis

21 January 2018

1 reference

Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse

21 January 2018

1 reference

Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways

21 January 2018

1 reference

Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS.

21 January 2018

1 reference

A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone

21 January 2018

1 reference

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

21 January 2018

1 reference

The choleretic mechanism of coumarin compounds and phenolic compounds

21 January 2018

1 reference

Effect of cycloheximide and dexamethasone phosphate on hyaluronic acid synthesis and secretion in cultured human skin fibroblasts

21 January 2018

1 reference

Hyaluronan cross-linking: a protective mechanism in inflammation?

21 January 2018

1 reference

Hyaluronan-binding proteins: tying up the giant

21 January 2018

1 reference

Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses

21 January 2018

1 reference

Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation.

21 January 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4991518

Pharmacokinetics and bioavailabilities of hymecromone in human volunteers

4 November 2018

1 reference

12 December 2020

Glucuronidation and sulfation in the rat in vivo. The role of the liver and the intestine in the in vivo clearance of 4-methylumbelliferone

1 reference

12 December 2020

Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts

1 reference

12 December 2020

Pharmacokinetic study of 4-methylumbelliferone in mice

1 reference

12 December 2020