(Q38865425)

7 September 2017

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title

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond (English)

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genome-wide association study

7 September 2017

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2

Kristel Sleegers

1 reference

7 September 2017

Elise Cuyvers

1

1 reference

7 September 2017

1 July 2016

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7 September 2017

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7 September 2017

15

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7 September 2017

8

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7 September 2017

857-868

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The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

7 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Neuropathological stageing of Alzheimer-related changes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Molecular genetics of Alzheimer's disease: an update

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Early-onset Alzheimer's disease is associated with greater pathologic burden

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

The patterns of inheritance in early-onset dementia: Alzheimer's disease and frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

The French Series of Autosomal Dominant Early Onset Alzheimer's Disease Cases: Mutation Spectrum and Cerebrospinal Fluid Biomarkers

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genetic risk of Alzheimer's disease: advising relatives.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genome-wide analysis of genetic loci associated with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genetic insights in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Alzheimer's disease risk genes and mechanisms of disease pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

The three new pathways leading to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Beyond GWASs: illuminating the dark road from association to function

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Alzheimer's risk variants in the clusterin gene are associated with alternative splicing

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

The sialoadhesin CD33 is a myeloid-specific inhibitory receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genome-wide scan for copy number variation association with age at onset of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Complement receptor 1 coding variant p.Ser1610Thr in Alzheimer's disease and related endophenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

SorLA signaling by regulated intramembrane proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Coding mutations in SORL1 and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

The contribution of genetic variants to disease depends on the ruler

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Alzheimer's disease: analyzing the missing heritability

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Role of Genes and Environments for Explaining Alzheimer Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Estimating missing heritability for disease from genome-wide association studies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Alzheimer's disease genes and cognition in the nondemented general population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Population-based analysis of Alzheimer's disease risk alleles implicates genetic interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Statistical analysis strategies for association studies involving rare variants

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

TREM2 Variants in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

TREM2 is associated with the risk of Alzheimer's disease in Spanish population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

PLD3 and sporadic Alzheimer's disease risk.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

PLD3 in non-familial Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

PLD3 gene variants and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

PLD3 variants in population studies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Rarity of the Alzheimer disease-protective APP A673T variant in the United States

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Clusterin is a secreted mammalian chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genic intolerance to functional variation and the interpretation of personal genomes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Validating therapeutic targets through human genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Efficacy and safety of alirocumab in reducing lipids and cardiovascular events

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Clinical utility of genetic and genomic services: a position statement of the American College of Medical Genetics and Genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Association of Alzheimer's disease GWAS loci with MRI markers of brain aging

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Predicting Alzheimer's Disease Using Combined Imaging-Whole Genome SNP Data

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Incremental value of rare genetic variants for the prediction of multifactorial diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Personalized medicine for effective Alzheimer disease treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

Precision medicine: Clarity for the clinical and biological complexity of Alzheimer's and Parkinson's diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

A genotype-first approach to defining the subtypes of a complex disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900127-7

7 January 2021

10.1016/S1474-4422(16)00127-7

Identifiers

DOI

1 reference

7 September 2017

1 reference

PubMed ID

27302364