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The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.
scientific article published on June 2015
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PMCID
4666840
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26028023%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
title
The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation
(English)
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Europe PubMed Central
PMCID
4666840
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16 February 2020
author
Lester F Lau
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3
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4666840
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16 February 2020
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C-C Chen
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1
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4666840
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16 February 2020
K-H Kim
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2
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4666840
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16 February 2020
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English
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publication date
1 June 2015
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16 February 2020
published in
Oncogene
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4666840
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16 February 2020
volume
35
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4666840
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16 February 2020
issue
10
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4666840
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16 February 2020
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1314-1323
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4666840
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16 February 2020
exact match
https://scigraph.springernature.com/pub.10.1038/onc.2015.190
0 references
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The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6.
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Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.
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p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species
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DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats
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Hepatitis B vs. hepatitis C infection on viral hepatitis-associated hepatocellular carcinoma.
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Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
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Cyr61/CCN1 is regulated by Wnt/β-catenin signaling and plays an important role in the progression of hepatocellular carcinoma
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Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace
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Tumor promotion via injury- and death-induced inflammation
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Hepatocellular carcinoma
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Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
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A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients.
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Hepatocellular carcinoma: A global view.
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9 September 2017
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
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Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo
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The matricellular protein CCN1 is essential for cardiac development
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The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts
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Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells
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Cyr61 suppresses growth of human endometrial cancer cells
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Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells
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Hepatocellular carcinoma
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CYR61 (CCN1) is essential for placental development and vascular integrity
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Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer
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9 September 2017
CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth
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N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation
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Cyr61/CCN1 is a tumor suppressor in human hepatocellular carcinoma and involved in DNA damage response
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14 September 2017
ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation
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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.
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Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
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Tumor suppression by p53: is apoptosis important or not?
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22 August 2018
Hepatocellular carcinoma - United States, 2001-2006.
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Isolation and culture of adult mouse hepatocytes
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Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis
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Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo
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22 August 2018
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
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22 August 2018
Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis
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Application of comparative functional genomics to identify best-fit mouse models to study human cancer
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Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways.
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22 August 2018
Cyr61 promotes breast tumorigenesis and cancer progression
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22 August 2018
Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF
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31 March 2020
Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
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31 March 2020
Identifiers
DOI
10.1038/ONC.2015.190
1 reference
stated in
Europe PubMed Central
PMCID
4666840
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26028023%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
Dimensions Publication ID
1053256652
0 references
PMCID
4666840
1 reference
stated in
Europe PubMed Central
PMCID
4666840
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26028023%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
PubMed ID
26028023
1 reference
stated in
Europe PubMed Central
PMCID
4666840
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26028023%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
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