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The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6.
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Europe PubMed Central
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4583322
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25807183%20AND%20SRC:MED&resulttype=core&format=json
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3 March 2020
title
The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6
(English)
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PMC publication ID
4583322
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3 March 2020
main subject
colitis
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author
Lester F Lau
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3
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4583322
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3 March 2020
author name string
J S Choi
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1
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4583322
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3 March 2020
K-H Kim
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2
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3 March 2020
publication date
25 March 2015
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3 March 2020
published in
Mucosal Immunology
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4583322
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25807183%20AND%20SRC:MED&resulttype=core&format=json
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3 March 2020
volume
8
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4583322
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3 March 2020
issue
6
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Europe PubMed Central
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4583322
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3 March 2020
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1285-1296
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3 March 2020
exact match
https://scigraph.springernature.com/pub.10.1038/mi.2015.19
0 references
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2 October 2017
Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking
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2 October 2017
Anti-IL-6 treatment for inflammatory bowel diseases: next cytokine, next target.
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New targets for mucosal healing and therapy in inflammatory bowel diseases
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2 October 2017
Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.
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2 October 2017
Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn's disease following treatment with certolizumab pegol
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Healing of intestinal inflammation by IL-22.
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2 October 2017
Adalimumab induces and maintains mucosal healing in patients with Crohn's disease: data from the EXTEND trial
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2 October 2017
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
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Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: a systematic literature review.
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CCN1/CYR61: the very model of a modern matricellular protein.
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2 October 2017
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 October 2017
Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages
1 reference
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PubMed Central
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2 October 2017
Clinical implications of mucosal healing for the management of IBD.
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2 October 2017
Inflammatory bowel disease
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PubMed Central
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2 October 2017
Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo
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PubMed Central
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2 October 2017
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 October 2017
Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 October 2017
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 October 2017
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 October 2017
IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 October 2017
Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease
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PubMed Central
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Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations
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2 October 2017
Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 October 2017
Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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Apolipoprotein A-IV inhibits experimental colitis
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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
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2 October 2017
CYR61 (CCN1) is essential for placental development and vascular integrity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
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Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 October 2017
Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 October 2017
Defective inflammatory response in interleukin 6-deficient mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice
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PubMed Central
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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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Chemically induced mouse models of intestinal inflammation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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2 July 2018
Beyond toll-like receptors: Porphyromonas gingivalis induces IL-6, IL-8, and VCAM-1 expression through NOD-mediated NF-κB and ERK signaling pathways in periodontal fibroblasts.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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23 September 2018
Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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23 September 2018
Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.
1 reference
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PubMed Central
reference URL
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23 September 2018
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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23 September 2018
Identification of a Novel Integrin αMβ2 Binding Site in CCN1 (CYR61), a Matricellular Protein Expressed in Healing Wounds and Atherosclerotic Lesions
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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23 September 2018
Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNFα therapy
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
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5 December 2018
Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583322
retrieved
5 December 2018
IL-6 is required for the development of Th1 cell-mediated murine colitis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25807183
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25807183
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interleukin-6 genetic ablation protects from trinitrobenzene sulfonic acid-induced colitis in mice. Putative effect of antiinflammatory cytokines
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25807183
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/MI.2015.19
1 reference
stated in
Europe PubMed Central
PMC publication ID
4583322
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25807183%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
PMC publication ID
4583322
1 reference
stated in
Europe PubMed Central
PMC publication ID
4583322
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25807183%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
PubMed publication ID
25807183
1 reference
stated in
Europe PubMed Central
PMC publication ID
4583322
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25807183%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
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