(Q35003977)

5 August 2017

title

New targets for mucosal healing and therapy in inflammatory bowel diseases (English)

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inflammatory bowel diseases

5 August 2017

main subject

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author name string

M F Neurath

series ordinal

1

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5 August 2017

publication date

2 October 2013

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5 August 2017

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5 August 2017

volume

7

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5 August 2017

issue

1

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5 August 2017

page(s)

6-19

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Changing Crohn's disease management: need for new goals and indices to prevent disability and improve quality of life

5 August 2017

cites work

1 reference

12 December 2020

The role of Th1/Th2 polarization in mucosal immunity

1 reference

12 December 2020

Epithelial NEMO links innate immunity to chronic intestinal inflammation

1 reference

12 December 2020

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

1 reference

12 December 2020

Toll-like receptor 9-induced type I IFN protects mice from experimental colitis

1 reference

12 December 2020

A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease

1 reference

12 December 2020

Mucin function in inflammatory bowel disease: an update

1 reference

12 December 2020

Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis.

1 reference

12 December 2020

Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety

1 reference

12 December 2020

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

1 reference

12 December 2020

CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice

1 reference

12 December 2020

1 reference

12 December 2020

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

1 reference

12 December 2020

Mucosal healing in inflammatory bowel diseases: a systematic review

1 reference

12 December 2020

Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease

1 reference

12 December 2020

Reduced Paneth cell alpha-defensins in ileal Crohn's disease

1 reference

12 December 2020

Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study

1 reference

12 December 2020

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

1 reference

12 December 2020

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

1 reference

12 December 2020

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

1 reference

12 December 2020

Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease.

1 reference

12 December 2020

T cell-dependent protective effects of CpG motifs of bacterial DNA in experimental colitis are mediated by CD11c+ dendritic cells

1 reference

12 December 2020

1 reference

12 December 2020

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

12 December 2020

Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis.

1 reference

12 December 2020

Abatacept for Crohn's disease and ulcerative colitis

1 reference

12 December 2020

Innate immune dysfunction in inflammatory bowel disease

1 reference

12 December 2020

CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile

1 reference

12 December 2020

Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis

1 reference

12 December 2020

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

1 reference

12 December 2020

Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages.

1 reference

12 December 2020

Rho GTPases and the control of cell behaviour

1 reference

12 December 2020

Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro.

1 reference

12 December 2020

Adalimumab safety in global clinical trials of patients with Crohn's disease

1 reference

12 December 2020

A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators

1 reference

12 December 2020

New and emerging treatments for ulcerative colitis: a focus on vedolizumab

1 reference

12 December 2020

Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis.

1 reference

12 December 2020

Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn's disease.

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12 December 2020

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

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12 December 2020

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production

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12 December 2020

Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation

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12 December 2020

IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice

1 reference

12 December 2020

Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial

1 reference

12 December 2020

Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis

1 reference

12 December 2020

TGF-beta1 and Smad7 in the regulation of IBD.

1 reference

12 December 2020

Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine

1 reference

12 December 2020

Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial

1 reference

12 December 2020

Adalimumab induces deep remission in patients with Crohn's disease.

1 reference

12 December 2020

Ustekinumab induction and maintenance therapy in refractory Crohn's disease

1 reference

12 December 2020

Cyclosporin for severe ulcerative colitis: a user's guide

1 reference

12 December 2020

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

1 reference

12 December 2020

Review article: the efficacy of infliximab in Crohn's disease--healing of fistulae

1 reference

12 December 2020

Review article: Causative factors and the clinical management of patients with Crohn's disease who lose response to anti-TNF-α therapy

1 reference

12 December 2020

Bispecific antibodies and trispecific immunocytokines for targeting the immune system against cancer: preparing for the future

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12 December 2020

Involvement of interleukin-21 in the regulation of colitis-associated colon cancer

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12 December 2020

p53 mediates TNF-induced epithelial cell apoptosis in IBD.

1 reference

12 December 2020

IL-27 promotes T cell-dependent colitis through multiple mechanisms

1 reference

12 December 2020

Intestinal growth factors: potential use in the treatment of inflammatory bowel disease and their role in mucosal healing

1 reference

12 December 2020

Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis

1 reference

12 December 2020

Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease

1 reference

12 December 2020

Rho activation regulates CXCL12 chemokine stimulated actin rearrangement and restitution in model intestinal epithelia.

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12 December 2020

Human beta defensin 2 promotes intestinal wound healing in vitro

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12 December 2020

Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae

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12 December 2020

Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice.

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12 December 2020

Infliximab, azathioprine, or combination therapy for Crohn's disease

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12 December 2020

Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alpha

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12 December 2020

Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial

1 reference

12 December 2020

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

1 reference

12 December 2020

TLR9 is important for protection against intestinal damage and for intestinal repair

1 reference

12 December 2020

Epithelial restitution and wound healing in inflammatory bowel disease

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12 December 2020

Predicting the response to infliximab from trough serum levels

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12 December 2020

1 reference

12 December 2020

Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins

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12 December 2020

Selective adhesion-molecule therapy and inflammatory bowel disease--a tale of Janus?

1 reference

12 December 2020

Neutralization of membrane TNF, but not soluble TNF, is crucial for the treatment of experimental colitis

1 reference

12 December 2020

Epithelial barriers in intestinal inflammation

1 reference

12 December 2020

Etanercept for the treatment of rheumatoid arthritis

1 reference

12 December 2020

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

1 reference

12 December 2020

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

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12 December 2020

Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis.

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12 December 2020

Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.

1 reference

12 December 2020

Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study

1 reference

12 December 2020

Intestinal barrier dysfunction in inflammatory bowel diseases.

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12 December 2020

Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF- plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens

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12 December 2020

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

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12 December 2020

Minireview: Glucocorticoids in autoimmunity: unexpected targets and mechanisms

1 reference

12 December 2020

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

1 reference

12 December 2020

Antibiotic treatment of Crohn's disease: results of a multicentre, double blind, randomized, placebo-controlled trial with rifaximin.

1 reference

12 December 2020

Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing.

1 reference

12 December 2020

Galectin-2 and -4, but not galectin-1, promote intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism

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12 December 2020

Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases

1 reference

12 December 2020

Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression

1 reference

12 December 2020

A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease

1 reference

12 December 2020

Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial

1 reference

12 December 2020

Long-term complications, extraintestinal manifestations, and mortality in adult Crohn's disease in population-based cohorts

1 reference

12 December 2020

Nuclear factor of activated T cells - a transcription factor family as critical regulator in lung and colon cancer

1 reference

12 December 2020

Common alleles that influence autophagy and the risk for inflammatory bowel disease

1 reference

12 December 2020

Rifaximin-Extended Intestinal Release Induces Remission in Patients With Moderately Active Crohn's Disease

1 reference

12 December 2020

Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody

1 reference

12 December 2020

A review and expert opinion of the use of certolizumab for Crohn's disease

1 reference

12 December 2020

Wound healing of intestinal epithelial cells

1 reference

12 December 2020

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

1 reference

12 December 2020

Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis

1 reference

12 December 2020

NFAT control of innate immunity

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12 December 2020

We once were blind and now we see: is it time to treat ulcerative colitis to achieve mucosal healing?

1 reference

12 December 2020

Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis.

1 reference

12 December 2020

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

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12 December 2020

Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease

1 reference

12 December 2020

Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta

1 reference

12 December 2020

1 reference

12 December 2020

Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis

1 reference

12 December 2020

Tumour necrosis factor (TNF) production by T cell receptor-primed T lymphocytes is a target for low dose methotrexate in rheumatoid arthritis

1 reference

12 December 2020

Randomized controlled trials in prevention of postsurgical recurrence in Crohn's disease

1 reference

12 December 2020

CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells

1 reference

12 December 2020

Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics

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12 December 2020

Methotrexate for the Treatment of Crohn's Disease

1 reference

12 December 2020

Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution

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12 December 2020

Antibodies to interleukin 12 abrogate established experimental colitis in mice

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12 December 2020

Replication of Crohn's disease-associated AIEC within macrophages is dependent on TNF-α secretion

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12 December 2020

Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort

1 reference

12 December 2020

Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group

1 reference

12 December 2020

Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis.

1 reference

12 December 2020

Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment

1 reference

12 December 2020

Phosphatidylcholine (lecithin) and the mucus layer: Evidence of therapeutic efficacy in ulcerative colitis?

1 reference

12 December 2020

Trichuris suis therapy in Crohn's disease

1 reference

12 December 2020

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1 reference

12 December 2020

Preliminary report: cyclosporin in treatment of severe active ulcerative colitis

1 reference

12 December 2020

Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells

1 reference

12 December 2020

IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue

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12 December 2020

Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease

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12 December 2020

TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury

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12 December 2020

Inflammatory bowel disease: dysfunction of autophagy?

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12 December 2020

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

1 reference

12 December 2020

Regulation of wound healing and organ fibrosis by toll-like receptors.

1 reference

12 December 2020

The role of IL-13 and NK T cells in experimental and human ulcerative colitis

1 reference

12 December 2020

Natalizumab Induction and Maintenance Therapy for Crohn's Disease

1 reference

12 December 2020

Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

1 reference

12 December 2020

Basiliximab does not increase efficacy of corticosteroids in patients with steroid-refractory ulcerative colitis

1 reference

12 December 2020

TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.

1 reference

12 December 2020

Tocilizumab: an interleukin-6 receptor inhibitor for the treatment of rheumatoid arthritis

1 reference

12 December 2020

Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor.

1 reference

12 December 2020

Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency

1 reference

12 December 2020

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

1 reference

12 December 2020

Vedolizumab for the treatment of active ulcerative colitis: a randomized controlled phase 2 dose-ranging study

1 reference

12 December 2020

Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-α on tight junction proteins and signaling pathways in intestinal epithelial cells

1 reference

12 December 2020

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

1 reference

12 December 2020

1 reference

12 December 2020

Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease

1 reference

12 December 2020

Granulocyte-macrophage colony-stimulating factor elicits bone marrow-derived cells that promote efficient colonic mucosal healing

1 reference

12 December 2020

Review article: the role of anti-TNF in the management of ulcerative colitis -- past, present and future

1 reference

12 December 2020

Regulation of intestinal barrier function by signal transducer and activator of transcription 5b.

1 reference

12 December 2020

Autophagy and the immune system

1 reference

12 December 2020

Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis

1 reference

12 December 2020

A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis

1 reference

12 December 2020

Tumor necrosis factor signaling.

1 reference

12 December 2020

Mucosal barrier in ulcerative colitis and Crohn's disease

1 reference

12 December 2020

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

1 reference

12 December 2020

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

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12 December 2020

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

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12 December 2020

Healing of intestinal inflammation by IL-22.

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12 December 2020

Anti-tumor necrosis factor-α antibodies induce regulatory macrophages in an Fc region-dependent manner

1 reference

12 December 2020

Cancer risk in patients with inflammatory bowel disease: a population-based study

1 reference

12 December 2020

The transcriptome of Trichuris suis--first molecular insights into a parasite with curative properties for key immune diseases of humans

1 reference

12 December 2020

Microbial-gut interactions in health and disease. Immune responses

1 reference

12 December 2020

A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease

1 reference

12 December 2020

Efficient colonic mucosal wound repair requires Trem2 signaling

1 reference

12 December 2020

Anti-interleukin-12 antibody for active Crohn's disease

1 reference

12 December 2020

Modulation of anti-tumor necrosis factor alpha (TNF-α) antibody secretion in mice immunized with TNF-α kinoid

1 reference

12 December 2020

Mucins in inflammatory bowel diseases and colorectal cancer

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12 December 2020

ADAM17: a molecular switch to control inflammation and tissue regeneration

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12 December 2020

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.

1 reference

12 December 2020

Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity

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12 December 2020

Selective inhibitors of nuclear factor of activated T cells: potential therapeutic drugs for the treatment of immunological and inflammatory diseases

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12 December 2020

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

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12 December 2020

Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer

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12 December 2020

Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis

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12 December 2020

Autoimmunity: The worm returns

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12 December 2020

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

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12 December 2020

Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

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12 December 2020

A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease

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12 December 2020

Clinical implications of mucosal healing for the management of IBD.

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12 December 2020

Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway

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12 December 2020

Colitis and colorectal cancer

1 reference

12 December 2020

Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis

1 reference

12 December 2020

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

1 reference

12 December 2020

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

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12 December 2020

Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta

1 reference

12 December 2020

A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease

1 reference

12 December 2020

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

1 reference

12 December 2020

Targeting IL-23 and Th17-cytokines in inflammatory bowel diseases

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12 December 2020

Drug monitoring of biologics in inflammatory bowel disease.

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12 December 2020

Selective targeting of activated T cells in chronic intestinal inflammation.

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12 December 2020

Leukocyte traffic blockade as a therapeutic strategy in inflammatory bowel disease

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMI.2013.73

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/MI.2013.73

1 reference

5 August 2017

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