(Q34501413)

2 August 2017

title

IL-27 promotes T cell-dependent colitis through multiple mechanisms (English)

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2 August 2017

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6

Nico Ghilardi

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author name string

Jennifer H Cox

1

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2 August 2017

Noelyn M Kljavin

2

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2 August 2017

Nandhini Ramamoorthi

3

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2 August 2017

Lauri Diehl

4

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2 August 2017

Marcel Batten

5

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2 August 2017

language of work or name

English

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publication date

20 December 2010

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Journal of Experimental Medicine

2 August 2017

published in

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2 August 2017

volume

208

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2 August 2017

issue

1

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2 August 2017

page(s)

115-123

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IL-35-mediated induction of a potent regulatory T cell population.

2 August 2017

cites work

1 reference

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The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling

7 July 2018

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Common variants at five new loci associated with early-onset inflammatory bowel disease

7 July 2018

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IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis

7 July 2018

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A protective function for interleukin 17A in T cell-mediated intestinal inflammation

7 July 2018

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The interleukin-23 axis in intestinal inflammation

7 July 2018

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Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

7 July 2018

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Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t

7 July 2018

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Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis

7 July 2018

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Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

7 July 2018

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The inhibitory cytokine IL-35 contributes to regulatory T-cell function

7 July 2018

1 reference

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Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

7 July 2018

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Interleukin-10 production by effector T cells: Th1 cells show self control

7 July 2018

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7 July 2018

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Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation

7 July 2018

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Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

7 July 2018

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CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis

7 July 2018

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Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs

7 July 2018

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Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

7 July 2018

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IL-27 limits IL-2 production during Th1 differentiation.

7 July 2018

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WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

7 July 2018

1 reference

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Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice

7 July 2018

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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

7 July 2018

1 reference

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The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease

7 July 2018

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Development of Th1-type immune responses requires the type I cytokine receptor TCCR

7 July 2018

1 reference

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Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023127

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023127

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

7 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20100410

T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20100410

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20100410

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20100410

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20100410

IL-27 inhibits the development of regulatory T cells via STAT3

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023127

The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

27 October 2018

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12 December 2020

Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1)

1 reference

12 December 2020

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

1 reference

12 December 2020

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

1 reference

12 December 2020

IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

1 reference

12 December 2020

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells

1 reference

12 December 2020

IL-27 induces a Th1 immune response and susceptibility to experimental arthritis

1 reference

12 December 2020

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells

1 reference

12 December 2020

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20100410

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2 August 2017

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2 August 2017

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