(Q33651440)

28 July 2017

title

IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis (English)

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28 July 2017

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8

David Artis

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28 July 2017

Amy E Troy

1

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28 July 2017

Colby Zaph

2

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28 July 2017

Yurong Du

3

1 reference

28 July 2017

Betsy C Taylor

4

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28 July 2017

Katherine J Guild

5

1 reference

28 July 2017

Christopher A Hunter

6

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28 July 2017

Christiaan J M Saris

7

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28 July 2017

language of work or name

English

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publication date

13 July 2009

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28 July 2017

published in

Journal of Immunology

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28 July 2017

volume

183

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28 July 2017

issue

3

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28 July 2017

page(s)

2037-2044

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Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

28 July 2017

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

21 June 2018

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21 June 2018

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21 June 2018

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Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

21 June 2018

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21 June 2018

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T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17

21 June 2018

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A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

21 June 2018

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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

21 June 2018

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21 June 2018

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Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis

21 June 2018

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 June 2018

1 reference

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Involvement of innate immunity in the development of inflammatory and autoimmune diseases.

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system

21 June 2018

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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Further checkpoints in Th1 development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Immunoregulation in the gut: success and failures in human disease.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Claudins regulate the intestinal barrier in response to immune mediators

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Antibodies to interleukin 12 abrogate established experimental colitis in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

IL-10 inhibits cytokine production by activated macrophages

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2821569

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

30 October 2018

1 reference

12 December 2020

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD

1 reference

12 December 2020

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

1 reference

12 December 2020

The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

1 reference

12 December 2020

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

1 reference

12 December 2020

The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis

1 reference

12 December 2020

IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38

1 reference

12 December 2020

Critical role of IL-17 receptor signaling in acute TNBS-induced colitis

1 reference

12 December 2020

TGF-beta, a 'double agent' in the immune pathology war

1 reference

12 December 2020

Role of toll-like receptors in spontaneous commensal-dependent colitis

1 reference

12 December 2020

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

1 reference

12 December 2020

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0802918

1 reference

28 July 2017

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28 July 2017

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