(Q38872061)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

hypertrophic cardiomyopathy

8 March 2020

main subject

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

16

J G Seidman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

17

Christine E Seidman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

9

Johan D Oslob

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

5

Joshua M Gorham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

2

Hiroko Wakimoto

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

author name string

Robert L Anderson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Marc J Evanchik

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Brooke C Harrison

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Marcus Henze

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Raja Kawas

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Hector M Rodriguez

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Yonghong Song

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

William Wan

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Leslie A Leinwand

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

James A Spudich

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Robert S McDowell

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

language of work or name

English

0 references

publication date

1 February 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

volume

351

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

issue

6273

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

page(s)

617-621

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

8 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Characterization of a phenotype-based genetic test prediction score for unrelated patients with hypertrophic cardiomyopathy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Influence of mechanical stress on fibroblast-myocyte interactions in mammalian heart

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Constitutive modeling of mouse carotid arteries using experimentally measured microstructural parameters.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Cardiac myosin activation: a potential therapeutic approach for systolic heart failure

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Increased left ventricular torsion in hypertrophic cardiomyopathy mutation carriers with normal wall thickness.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

A mouse model of familial hypertrophic cardiomyopathy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Myosin transitions in the bovine and human heart. A developmental and anatomical study of heavy and light chain subunits in the atrium and ventricle

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Impaired Rate of Left Ventricular Filling in Idiopathic Hypertrophic Subaortic Stenosis and Valvular Aortic Stenosis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Early changes in apical rotation in genotype positive children with hypertrophic cardiomyopathy mutations without hypertrophic changes on two-dimensional imaging.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

EFFECT OF LEFT VENTRICULAR SIZE AND SHAPE UPON THE HEMODYNAMICS OF SUBAORTIC STENOSIS.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

Clinical course of hypertrophic cardiomyopathy in a regional United States cohort

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784435

STAR: ultrafast universal RNA-seq aligner

22 August 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD3456

5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD3456

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD3456

Structure of the actin-myosin complex and its implications for muscle contraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD3456

Cyclic stretch induces the release of growth promoting factors from cultured neonatal cardiomyocytes and cardiac fibroblasts

21 January 2018

1 reference

12 December 2020

Relation between myocyte disarray and outcome in hypertrophic cardiomyopathy

1 reference

12 December 2020

Hypertrophic cardiomyopathy

1 reference

12 December 2020

The pathogenesis of familial hypertrophic cardiomyopathy: early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation

1 reference

12 December 2020

Dynamics of left ventricular emptying in hypertrophic subaortic stenosis. A cineangiographic and hemodynamic study

1 reference

12 December 2020

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated

1 reference

12 December 2020

Assessment of Diastolic Function With Doppler Tissue Imaging to Predict Genotype in Preclinical Hypertrophic Cardiomyopathy

1 reference

12 December 2020

Identifiers

DOI

10.1126/SCIENCE.AAD3456

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26912705%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference