(Q38898283)

7 September 2017

Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation (English)

1 reference

7 September 2017

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25784353%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Samir K Maji

9

1 reference

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6 June 2020

author name string

Dhiman Ghosh

1

1 reference

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6 June 2020

Pradeep K Singh

2

1 reference

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6 June 2020

Shruti Sahay

3

1 reference

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6 June 2020

Narendra Nath Jha

4

1 reference

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6 June 2020

Reeba S Jacob

5

1 reference

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6 June 2020

Ashutosh Kumar

7

1 reference

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6 June 2020

Roland Riek

8

1 reference

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6 June 2020

language of work or name

English

0 references

publication date

18 March 2015

1 reference

7 September 2017

1 reference

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6 June 2020

volume

5

1 reference

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6 June 2020

page(s)

9228

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Creative Commons Attribution 4.0 International

6 June 2020

copyright license

start time

18 March 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/srep09228

0 references

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Elucidating the role of disulfide bond on amyloid formation and fibril reversibility of somatostatin-14: relevance to its storage and secretion

9 September 2017

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Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.

9 September 2017

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The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes

9 September 2017

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G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome

9 September 2017

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Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

9 September 2017

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A novel α-synuclein missense mutation in Parkinson disease

9 September 2017

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α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

9 September 2017

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Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.

9 September 2017

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

9 September 2017

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Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation

9 September 2017

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Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective

9 September 2017

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A partially folded structure of amyloid-beta(1-40) in an aqueous environment

9 September 2017

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In vivo demonstration that alpha-synuclein oligomers are toxic

9 September 2017

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Natural tri- to hexapeptides self-assemble in water to amyloid beta-type fiber aggregates by unexpected alpha-helical intermediate structures

9 September 2017

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Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation

9 September 2017

1 reference

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Human serum albumin inhibits Abeta fibrillization through a "monomer-competitor" mechanism

9 September 2017

1 reference

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A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides

9 September 2017

1 reference

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Amino acid position-specific contributions to amyloid beta-protein oligomerization.

9 September 2017

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Alpha-helix targeting reduces amyloid-beta peptide toxicity

9 September 2017

1 reference

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Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy

9 September 2017

1 reference

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The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

A role for helical intermediates in amyloid formation by natively unfolded polypeptides?

9 September 2017

1 reference

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Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy

9 September 2017

1 reference

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Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Infrared spectroscopy of proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

9 September 2017

1 reference

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Direct detection of transient alpha-helical states in islet amyloid polypeptide

9 September 2017

1 reference

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Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

An enzymatic molten globule: efficient coupling of folding and catalysis.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

alpha-Synuclein locus triplication causes Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Transgenic models of alpha-synuclein pathology: past, present, and future

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Multistep nucleus formation and a separate subunit contribution of the amyloidgenesis of heat-denatured monellin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

A Drosophila model of Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Amyloid fibrillogenesis: themes and variations

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Alpha-synuclein in Lewy bodies

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

A new microcellular cytotoxicity test based on calcein AM release

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Curcumin modulates α-synuclein aggregation and toxicity.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

A causative link between the structure of aberrant protein oligomers and their toxicity.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Synergistic inhibition of human neuroblastoma-related angiogenesis by vinblastine and rapamycin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Amyloids of alpha-synuclein affect the structure and dynamics of supported lipid bilayers.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Structural characterization and inhibition of toxic amyloid-β oligomeric intermediates

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

BRICHOS domains efficiently delay fibrillation of amyloid β-peptide.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Stoichiometry and affinity of the human serum albumin-Alzheimer's Aβ peptide interactions

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Mechanistic studies of peptide self-assembly: transient α-helices to stable β-sheets

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Amyloid fibril formation and protein misassembly: a structural quest for insights into amyloid and prion diseases

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Hydrogen peroxide mediates amyloid beta protein toxicity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Site-specific fluorescence dynamics of α-synuclein fibrils using time-resolved fluorescence studies: effect of familial Parkinson's disease-associated mutations

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

ANS binding reveals common features of cytotoxic amyloid species

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Alpha-synuclein is localized in a subpopulation of rat brain synaptic vesicles.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Amyloid formation by pro-islet amyloid polypeptide processing intermediates: examination of the role of protein heparan sulfate interactions and implications for islet amyloid formation in type 2 diabetes

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Alpha-synuclein multistate folding thermodynamics: implications for protein misfolding and aggregation

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

On the analysis of membrane protein circular dichroism spectra

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Dissecting the assembly of Abeta16-22 amyloid peptides into antiparallel beta sheets.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Conformational behavior and aggregation of alpha-synuclein in organic solvents: modeling the effects of membranes

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein a-I.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Kinetic studies of amyloid beta-protein fibril assembly. Differential effects of alpha-helix stabilization

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Sequence-dependent correction of random coil NMR chemical shifts

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Conformational properties of alpha-synuclein in its free and lipid-associated states

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

Structural and kinetic features of amyloid beta-protein fibrillogenesis.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363886

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

22 August 2018

1 reference

12 December 2020

Inter-helix distances in lysophospholipid micelle-bound alpha-synuclein from pulsed ESR measurements

1 reference

12 December 2020

Fibrillogenic and non-fibrillogenic ensembles of SDS-bound human alpha-synuclein

1 reference

12 December 2020

Mapping polypeptide self-recognition through (1)H off-resonance relaxation

1 reference

12 December 2020

Secondary structure of alpha-synuclein oligomers: characterization by raman and atomic force microscopy

1 reference

12 December 2020

The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates α-synuclein aggregation and membrane binding

1 reference

12 December 2020

The presence of an air-water interface affects formation and elongation of α-Synuclein fibrils

1 reference

12 December 2020

Alpha-synuclein and Parkinson's disease

1 reference

12 December 2020

Principles of Fluorescence Spectroscopy

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSREP09228

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/SREP09228

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25784353%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25784353%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25784353%20AND%20SRC:MED&resulttype=core&format=json