(Q36238193)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

Michele Francesco Maria Sciacca

12 February 2020

author

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Jeffrey Brender

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Ayyalusamy Ramamoorthy

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Samuel A Kotler

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Jennifer Chen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Dong-kuk Lee

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

1 August 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

number of pages

9

1 reference

inferred from page(s)

published in

Biophysical Journal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

103

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

702-710

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons

12 February 2020

cites work

1 reference

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1 October 2017

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

1 October 2017

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Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions

1 October 2017

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Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity

1 October 2017

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Lipid matrix plays a role in Abeta fibril kinetics and morphology

1 October 2017

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1 October 2017

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β-Barrel topology of Alzheimer's β-amyloid ion channels

1 October 2017

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Amyloid peptide pores and the beta sheet conformation.

1 October 2017

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Calcium signaling and amyloid toxicity in Alzheimer disease

1 October 2017

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Simultaneous single-molecule fluorescence and conductivity studies reveal distinct classes of Abeta species on lipid bilayers

1 October 2017

1 reference

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Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels

1 October 2017

1 reference

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Amyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversy

1 October 2017

1 reference

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Dysregulation of calcium homeostasis in Alzheimer's disease

1 October 2017

1 reference

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The role of Abeta-induced calcium dysregulation in the pathogenesis of Alzheimer's disease.

1 October 2017

1 reference

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Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity

1 October 2017

1 reference

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The interaction of amyloid Abeta(1-40) with lipid bilayers and ganglioside as studied by 31P solid-state NMR.

1 October 2017

1 reference

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Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Membrane fragmentation by an amyloidogenic fragment of human Islet Amyloid Polypeptide detected by solid-state NMR spectroscopy of membrane nanotubes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm

1 October 2017

1 reference

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Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers

1 October 2017

1 reference

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Physicochemical interactions of amyloid beta-peptide with lipid bilayers

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer's disease Abeta ion channel and cytotoxicity.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Amyloid ion channels: a common structural link for protein-misfolding disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

MSI-78, an Analogue of the Magainin Antimicrobial Peptides, Disrupts Lipid Bilayer Structure via Positive Curvature Strain

1 October 2017

1 reference

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Amyloid-beta peptide assembly: a critical step in fibrillogenesis and membrane disruption

1 October 2017

1 reference

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Amyloid beta protein (1-40) forms calcium-permeable, Zn2+-sensitive channel in reconstituted lipid vesicles

1 October 2017

1 reference

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Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons

1 October 2017

1 reference

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Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity

1 October 2017

1 reference

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Zn2+ interaction with Alzheimer amyloid beta protein calcium channels

1 October 2017

1 reference

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Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

1 October 2017

1 reference

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A new generation of Ca2+ indicators with greatly improved fluorescence properties

1 October 2017

1 reference

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Alzheimer's disease: the amyloid cascade hypothesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Real-time observation of model membrane dynamics induced by Alzheimer's amyloid beta.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Membrane disruption by Alzheimer beta-amyloid peptides mediated through specific binding to either phospholipids or gangliosides. Implications for neurotoxicity.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

The distributions and diffusivities of small ions in chondroitin sulphate, hyaluronate and some proteoglycan solutions.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Mechanism of amyloid β-protein aggregation mediated by GM1 ganglioside clusters.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Amyloid-beta membrane binding and permeabilization are distinct processes influenced separately by membrane charge and fluidity

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

In situ Abeta pores in AD brain are cylindrical assembly of Abeta protofilaments.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Anticancer cisplatin interactions with bilayers of total lipid extract from pig brain: A13C, 31P and 15N solid-state NMR study

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Driving force of binding of amyloid beta-protein to lipid bilayers

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Amyloid peptide channels: blockade by zinc and inhibition by Congo red (amyloid channel block).

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443794

Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates

22 September 2018

1 reference

12 December 2020

Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers

1 reference

12 December 2020

Membrane integrity and amyloid cytotoxicity: a model study involving mitochondria and lysozyme fibrillation products

1 reference

12 December 2020

Early and late cytotoxic effects of external application of the Alzheimer's Abeta result from the initial formation and function of Abeta ion channels

1 reference

12 December 2020

Colorimetric determination of phospholipids with ammonium ferrothiocyanate

1 reference

12 December 2020

10.1016/J.BPJ.2012.06.045

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22947931%20AND%20SRC:MED&resulttype=core&format=json