(Q38909260)

7 September 2017

title

Structural Mechanisms in NLR Inflammasome Assembly and Signaling (English)

1 reference

7 September 2017

1 reference

Zehan Hu

1

1 reference

7 September 2017

Jijie Chai

series ordinal

2

1 reference

7 September 2017

publication date

1 January 2016

1 reference

Current Topics in Microbiology and Immunology

7 September 2017

published in

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7 September 2017

volume

397

1 reference

7 September 2017

page(s)

23-42

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

7 September 2017

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21 January 2018

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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

21 January 2018

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21 January 2018

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

21 January 2018

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Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing

21 January 2018

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

21 January 2018

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Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

21 January 2018

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An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

21 January 2018

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21 January 2018

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Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor

21 January 2018

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Wheel of Life, Wheel of Death: A Mechanistic Insight into Signaling by STAND Proteins.

21 January 2018

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The inflammasome NLRs in immunity, inflammation, and associated diseases

21 January 2018

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Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)

21 January 2018

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Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation

21 January 2018

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Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

21 January 2018

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Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

21 January 2018

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

21 January 2018

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Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

21 January 2018

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

21 January 2018

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Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

21 January 2018

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Evolution of innate and adaptive immunity: can we draw a line?

21 January 2018

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

21 January 2018

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Crystal structure of NLRC4 reveals its autoinhibition mechanism

21 January 2018

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Structural and biochemical basis for induced self-propagation of NLRC4.

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Inflammasome recognition of influenza virus is essential for adaptive immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Innate immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Fungal pathogen recognition by the NLRP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

21 January 2018

The plant immune system

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

SMOCs: supramolecular organizing centres that control innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

The evolution and genetics of innate immunity

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

An inherited mutation in NLRC4 causes autoinflammation in human and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Inflammasomes and their roles in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Mechanisms and functions of inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP

21 January 2018

1 reference

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Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Structural mechanisms of inflammasome assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

NLR functions in plant and animal immune systems: so far and yet so close

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Cryopyrin activates the inflammasome in response to toxins and ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Gout-associated uric acid crystals activate the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

The inflammasomes: guardians of the body

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Innate immunity: the virtues of a nonclonal system of recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Human astrocytes express a novel NLRP2 inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Antimicrobial defense of the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Structure of the apoptotic protease-activating factor 1 bound to ADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Role of the HIN domain in regulation of innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Inflammatory caspases are innate immune receptors for intracellular LPS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Signalling pathways and molecular interactions of NOD1 and NOD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Inflammasomes in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Pattern recognition receptors and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Resistance proteins: molecular switches of plant defence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

IFI16 is an innate immune sensor for intracellular DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

The NLRP12 inflammasome recognizes Yersinia pestis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Recognition of bacteria by inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

An autoactive mutant of the M flax rust resistance protein has a preference for binding ATP, whereas wild-type M protein binds ADP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

The nucleic acid-sensing inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Apoptosome structure, assembly, and procaspase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41171-2_2

10.1007/978-3-319-41171-2_2

31 March 2020

Identifiers

DOI

1 reference

7 September 2017

1 reference