(Q38966735)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25117203%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays (English)

1 reference

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12 March 2020

6

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12 March 2020

author name string

Richard A Dean

1

1 reference

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12 March 2020

Hok Khim Fam

2

1 reference

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12 March 2020

Jianghong An

3

1 reference

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12 March 2020

Kunho Choi

4

1 reference

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12 March 2020

Yoko Shimizu

5

1 reference

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12 March 2020

Cornelius F Boerkoel

7

1 reference

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12 March 2020

Heidrun Interthal

8

1 reference

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12 March 2020

Tom A Pfeifer

9

1 reference

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12 March 2020

publication date

12 August 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25117203%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biomolecular Screening

12 March 2020

published in

1 reference

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12 March 2020

volume

19

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12 March 2020

issue

10

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12 March 2020

page(s)

1372-1382

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Amplifying tumour-specific replication lesions by DNA repair inhibitors - a new era in targeted cancer therapy

12 March 2020

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Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer

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TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells

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TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

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The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

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21 January 2018

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Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

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Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages

21 January 2018

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TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

21 January 2018

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Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

21 January 2018

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Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation

21 January 2018

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21 January 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

21 January 2018

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

21 January 2018

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TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

21 January 2018

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PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.

21 January 2018

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Synthetic enhancement in gene interaction: a genetic tool come of age.

21 January 2018

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Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

21 January 2018

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Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

21 January 2018

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4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors

21 January 2018

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

21 January 2018

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Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors

21 January 2018

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