(Q38971720)

8 September 2017

title

Rapid Lentiviral Transduction Preserves the Engraftment Potential of Fanca-/- Hematopoietic Stem Cells (English)

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8 September 2017

4

Axel Schambach

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author name string

Lars Uw Müller

1

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8 September 2017

Michael D Milsom

2

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8 September 2017

Mi-Ok Kim

3

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8 September 2017

Todd Schuesler

5

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8 September 2017

David A Williams

6

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8 September 2017

language of work or name

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1 June 2008

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8 September 2017

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8 September 2017

volume

16

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8 September 2017

issue

6

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8 September 2017

page(s)

1154-1160

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Molecular pathogenesis of Fanconi anemia: recent progress

8 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.67

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Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants

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Matched sibling donor haematopoietic stem cell transplantation in Fanconi anaemia: an update of the Cincinnati Children's experience.

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Retroviral mediated gene transfer of the Fanconi anemia complementation group C gene to hematopoietic progenitors of group C patients

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Phenotype correction of Fanconi anemia group A hematopoietic stem cells using lentiviral vector

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7 January 2021

Engraftment of hematopoietic progenitor cells transduced with the Fanconi anemia group C gene (FANCC)

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7 January 2021

Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy

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Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection

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Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles

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Rapid 1-hour transduction of whole bone marrow leads to long-term repopulation of murine recipients with lentivirus-modified hematopoietic stem cells

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7 January 2021

Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation.

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Mice with a targeted disruption of the Fanconi anemia homolog Fanca

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Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1

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In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning

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Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector

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Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection

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A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients.

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Reverse mosaicism in Fanconi anemia: natural gene therapy via molecular self-correction

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Somatic mosaicism in Fanconi anemia: evidence of genotypic reversion in lymphohematopoietic stem cells.

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Correction of Fanconi anemia type C phenotypic abnormalities using a clinically suitable retroviral vector infection protocol

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7 January 2021

Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

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Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

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7 January 2021

Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

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7 January 2021

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7 January 2021

Continuous in vivo infusion of interferon-gamma (IFN-gamma) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc-/- mice

1 reference

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7 January 2021

Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice

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7 January 2021

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7 January 2021

A third-generation lentivirus vector with a conditional packaging system

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7 January 2021

Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

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7 January 2021

Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression

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7 January 2021

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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7 January 2021

Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts

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7 January 2021

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

1 reference

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7 January 2021

Real-Time PCR: an Effective Tool for Measuring Transduction Efficiency in Human Hematopoietic Progenitor Cells

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7 January 2021

Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials.

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7 January 2021

Identifiers

DOI

10.1038/MT.2008.67

1 reference

8 September 2017

1 reference