(Q38999607)

8 September 2017

title

Obatoclax induces G1/G0-phase arrest via p38/p21(waf1/Cip1) signaling pathway in human esophageal cancer cells (English)

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8 September 2017

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Desheng Zhong

1

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8 September 2017

Chunping Gu

2

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8 September 2017

Lili Shi

3

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8 September 2017

Tianrong Xun

4

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8 September 2017

Xiaojuan Li

5

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8 September 2017

Shuwen Liu

6

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8 September 2017

Le Yu

7

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8 September 2017

publication date

1 September 2014

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Journal of Cellular Biochemistry

8 September 2017

published in

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8 September 2017

volume

115

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8 September 2017

issue

9

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8 September 2017

page(s)

1624-1635

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Cell cycle regulation by p38 MAP kinases

8 September 2017

cites work

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Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

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Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

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Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress

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Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo

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BCL-x(L) and BCL2 delay Myc-induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin-dependent kinases

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Establishment and characterization of HKESC-1, a new cancer cell line from human esophageal squamous cell carcinoma

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The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

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Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

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Obatoclax mesylate : pharmacology and potential for therapy of hematological neoplasms

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Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

21 January 2018

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A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells

21 January 2018

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Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

21 January 2018

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Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

21 January 2018

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Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death

21 January 2018

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Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

21 January 2018

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

21 January 2018

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Experience with obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma.

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis

21 January 2018

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A phase II study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in relapsed small cell lung cancer

21 January 2018

1 reference

Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis

21 January 2018

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The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation

21 January 2018

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GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells

21 January 2018

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BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells.

21 January 2018

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BH3-only proteins: Orchestrators of apoptosis

21 January 2018

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Anticancer drug targets: cell cycle and checkpoint control.

21 January 2018

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Cell-cycle dysregulation and anticancer therapy

21 January 2018

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Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.

21 January 2018

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Non-classical p38 map kinase functions: cell cycle checkpoints and survival

21 January 2018

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Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia

21 January 2018

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Expression of apoptosis-related proteins in Barrett's metaplasia-dysplasia-carcinoma sequence: a switch to a more resistant phenotype.

21 January 2018

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Different forms of cell death induced by putative BCL2 inhibitors.

21 January 2018

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Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics

21 January 2018

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Enhancement of doxorubicin cytotoxicity on human esophageal squamous cell carcinoma cells by indomethacin and 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC236) via inhibiting P-glycoprotein activity

21 January 2018

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E series of prostaglandin receptor 2-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma

21 January 2018

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

21 January 2018

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The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.24829

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8 September 2017

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