(Q37983083)

26 August 2017

title

Obatoclax mesylate : pharmacology and potential for therapy of hematological neoplasms (English)

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26 August 2017

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Jamal Joudeh

1

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26 August 2017

David Claxton

series ordinal

2

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26 August 2017

language of work or name

English

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publication date

11 February 2012

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Expert Opinion on Investigational Drugs

26 August 2017

published in

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26 August 2017

volume

21

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26 August 2017

issue

3

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26 August 2017

page(s)

363-373

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Bcl-2 family proteins and cancer

26 August 2017

cites work

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21 January 2018

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

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21 January 2018

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BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.

21 January 2018

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21 January 2018

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The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy

21 January 2018

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GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy

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The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

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Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis

21 January 2018

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21 January 2018

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The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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AT-101 (R-(-)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model

21 January 2018

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

21 January 2018

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The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies

21 January 2018

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10.1517/13543784.2012.652302

21 January 2018

Identifiers

DOI

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26 August 2017

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