(Q42438129)

English

BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.

scientific article published on 3 July 2008

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scholarly article

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9 January 2020

BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells (English)

1 reference

Europe PubMed Central

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9 January 2020

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phosphorylation

1 reference

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inferred from title

chronic lymphocytic leukemia

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based on heuristic

inferred from title

2

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9 January 2020

8

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9 January 2020

9

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9 January 2020

author name string

P Pérez-Galán

1

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9 January 2020

M López-Guerra

3

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9 January 2020

M Nguyen

4

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9 January 2020

N Villamor

5

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9 January 2020

E Montserrat

6

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9 January 2020

G C Shore

7

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9 January 2020

publication date

3 July 2008

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9 January 2020

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9 January 2020

22

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9 January 2020

9

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9 January 2020

1712-1720

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9 January 2020

https://scigraph.springernature.com/pub.10.1038/leu.2008.175

0 references

Chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

The Bcl-2 apoptotic switch in cancer development and therapy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Bcl-2 phosphorylation required for anti-apoptosis function

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Bcl2 phosphorylation and active PKC alpha are associated with poor survival in AML.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective Inhibition of I B Kinase Sensitizes Mantle Cell Lymphoma B Cells to TRAIL by Decreasing Cellular FLIP Level

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

miR-15 and miR-16 induce apoptosis by targeting BCL2

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

BCL-2 family regulation by the 20S proteasome inhibitor bortezomib

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/LEU.2008.175

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18596739%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

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9 January 2020

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